Royal Jelly Increases High Density Lipoprotein Levels but in Older Patients Only

doi:10.1089/acm.2008.0420

Cited by 9 publications

(5 citation statements)

References 7 publications

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“…Serum LDL concentration was gradually and significantly reduced in treated rabbits with RCJ at any doses and the values were 12.73, 24.17 and 24.71% below the control group value, while serum HDL concentration was increased by 3.78, 8.39 and 9.68% above the control level and this effect was significant (P<0.05) at any RJ dose. These results support the findings of Münstedt et al, (2009), as they showed that in elderly people eating RJ 10 g/d for 14 d showed an increase in serum HDL and a decrease in LDL levels. Similarly, Elnagar (2010) reported that serum total lipids, cholesterol and triglycerides were decreased in heat-stressed male rabbits treated with 200, 400 or 800 mg RJ/kg BW.…”

Section: World Rabbit Sci 22: 241-248supporting

confidence: 91%

“…In elderly people, eating RJ (10 g/daily for 14 d) showed an increase in serum high density lipids (HDL) level and a decrease in low density lipids (LDL) level, without affecting serum triglycerides (Münstedt et al, 2009). In rabbits, adding 50-100 mg RJ/d reduced serum total cholesterol level by 14% and total lipids by 10% (Vittek, 1995).The same results were found by Guo et al (2007) and Abou-Hozaifa et al (1995) in rats fed a cholesterol-enriched diet.…”

Section: Introductionmentioning

confidence: 99%

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Impact of royal jelly to improve reproductive performance of male rabbits under hot summer conditions

El-Hanoun¹,

Elkomy²,

Fares³

et al. 2014

World rabbit sci.

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To alleviate the deleterious effect of heat stress during summer conditions on male rabbits' reproduction, 40 V Line adult rabbit bucks (on av. 8 mo old) were divided into 4 experimental groups and exposed to temperatures ranging from 23 to 36°C. Bucks in the 1 st , 2 nd , 3 rd , and 4 th group were supplemented with 0, 50, 100 or 150 mg of Chinese royal jelly (RJ)/kg twice per week, respectively, over a 20-wk period. Semen quality and blood biochemical constituents were evaluated. RJ at any dose exhibited a significant increase (P<0.05) in rabbits' sperm concentration, total sperm output, sperm motility, live sperm and normal sperm compared to the untreated controls. Plasma total protein, albumin, globulin, glucose and high density lipids (HDL) concentrations were significantly (P<0.05) boosted in the RJ groups compared to the controls. In contrast, RJ treatment resulted in a significant (P<0.05) reduction in plasma total lipids, triglycerides, cholesterol and low density lipids (LDL) concentrations. Treatment with RJ significantly boosted (P<0.05) testosterone concentration in the RJ groups to reach 110, 120 and 128%, respectively, of the control group. Improved kidney and liver functions were observed in the RJ bucks groups where plasma creatinine, urea concentrations, aspartate aminotransferase and alanine aminotransferase enzyme activities were significantly (P<0.05) decreased by RJ treatments. Treating bucks subjected to heat stress by different RJ doses increased (P<0.05) total antioxidant capacity to 106, 111 and 115% of basal, but significantly reduced (P<0.05) malondialdehyde and thiobarbituric acid reactive substances compared to the untreated. It was concluded that Chinese royal jelly supplementation for heat-stressed male rabbits can counteract summer infertility and improve their physiological status.

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Section: World Rabbit Sci 22: 241-248supporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Impact of royal jelly to improve reproductive performance of male rabbits under hot summer conditions

El-Hanoun¹,

Elkomy²,

Fares³

et al. 2014

World rabbit sci.

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“…The healthspan-inducing effects of RJ in humans are not only limited to enhancement of physical health but also include improvement of general mental health [74], reduction of anxiety symptoms [93], improvement of mood, and mild cognitive impairment in the elderly (>60 years old) [98,99]. The psychological and neurological effects of RJ reflect improvement of biomarkers of physical health such as cholesterol [98]. Hypercholesterolemia, in particular, is documented to foster aggregation of β-amyloid around neurons, which causes neuronal loss—a characteristic feature of Alzheimer’s disease.…”

Section: Rj Might Enhance Longevity In Humans By Promoting Generalmentioning

confidence: 99%

Royal Jelly and Its Components Promote Healthy Aging and Longevity: From Animal Models to Humans

Kunugi

Ali

2019

IJMS

143

154

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Aging is a natural phenomenon that occurs in all living organisms. In humans, aging is associated with lowered overall functioning and increased mortality out of the risk for various age-related diseases. Hence, researchers are pushed to find effective natural interventions that can promote healthy aging and extend lifespan. Royal jelly (RJ) is a natural product that is fed to bee queens throughout their entire life. Thanks to RJ, bee queens enjoy an excellent reproductive function and lengthened lifespan compared with bee workers, despite the fact that they have the same genome. This review aimed to investigate the effect of RJ and/or its components on lifespan/healthspan in various species by evaluating the most relevant studies. Moreover, we briefly discussed the positive effects of RJ on health maintenance and age-related disorders in humans. Whenever possible, we explored the metabolic, molecular, and cellular mechanisms through which RJ can modulate age-related mechanisms to extend lifespan. RJ and its ingredients—proteins and their derivatives e.g., royalactin; lipids e.g., 10-hydroxydecenoic acid; and vitamins e.g., pantothenic acid—improved healthspan and extended lifespan in worker honeybees Apis mellifera, Drosophila Melanogaster flies, Gryllus bimaculatus crickets, silkworms, Caenorhabditis elegans nematodes, and mice. The longevity effect was attained via various mechanisms: downregulation of insulin-like growth factors and targeting of rapamycin, upregulation of the epidermal growth factor signaling, dietary restriction, and enhancement of antioxidative capacity. RJ and its protein and lipid ingredients have the potential to extend lifespan in various creatures and prevent senescence of human tissues in cell cultures. These findings pave the way to inventing specific RJ anti-aging drugs. However, much work is needed to understand the effect of RJ interactions with microbiome, diet, activity level, gender, and other genetic variation factors that affect healthspan and longevity.

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“…Generally, RJ administration to growing rabbits improved their performance as observed with better weight gain and feed utilization, which was associated with better feed utilization and without adversely effects on health status (Elnagar et al, 2010). Beneficial effects of RJ were reported on increasing protein metabolites in chickens (Kurkure et al,2000) and serum high density lipoproteins (HDL) level, while reduced triglycerides and cholesterol (Pizzorno et al, 2007) and low density lipoproteins (LDL) level, without affecting serum triglycerides in human (Munstedt et al, 2009). Also, RJ reduced total cholesterol level by 14% and total lipids by 10% in rabbits (Vittek, 1995).…”

Section: Introductionmentioning

confidence: 98%

Effect of Some Natural Antioxidants on Growth Performance, Blood Parameters and Carcass Traits of Growing Rabbits Under Egyptian Summer Condition

Gabr¹,

Younan²,

Hamad³

et al. 2016

Journal of Animal and Poultry Production

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The current study aimed to evaluate the effect of treatment with combination of royal Jelly (RJ) plus green tea (GT) or propolis (PR) plus GT on thermo-physiological response, growth performance, blood biochemicals and carcass traits. Total of 60 NZW weaned rabbits (5 wk of age and 703.03±11.59 g LBW) were assigned into three similar groups of 20 rabbits in each (10 males and 10 females). Rabbits in the 1 st and 2 nd groups were fed complete feed diet (CFD) supplemented with 2 g GT/kg and orally treatment twice/week with 150 mg RJ/kg (G1) or 0.5 g PR/kg LBW (G2). However, rabbits in the 3 rd group were fed the same CFD without any supplements and orally treated with one ml saline and served as a control group (G3). Throughout the experimental period (August and September months), temperature humidity index (THI), rectal temperature (RT), LBW, feed intake (FI), viability rate and performance index (PI) were recorded, and daily weight gain (DWG) and feed conversion ratio(FCR) were calculated at 5-9, 9-13 and 5-13 age intervals. Blood samples were collected from three males from each group for determination of total proteins (TP), albumin (AL), glucose, cholesterol, triglycerides, high density lipoproteins (HDL), low density lipoproteins (LDL), creatinine, urea, triiodothyronine (T3) and tetraiodothyronine (T4) concentrations, as well as activity of aspartate (AST) and alanine (ALT) transaminases in serum. At 13 wk of age, three males from each group were slaughtered to evaluate carcass traits. Meat samples from hind limb were taken for chemical analysis. Results show that rabbits extremely severed from heat stress throughout all months studied. RT reduced in G2 (P<0.05) and G1 (P≥0.05) as compared to G1, being better in males than in females. Both G1 and G2 showed marked improvement in LBW, DWG, RGR, FI, FCR and PI as compared to G3, being with the best G2, in particular, at 5-9 wk of age. VR was the highest in G1, and higher in females than females only in G2. Concentrations of TP, AL, GL, AL: GL ratio, total cholesterol, triglycerides, LDL, HDL, creatinine and urea as well as activity of ALT in blood serum were not affected by treatment. Serum glucose concentration was higher (P<0.05) in G2 than in G1, while both groups did not varied significantly from that in G1. Also, AST activity in serum reduced (P<0.05) in G1, but did not differ in G2 as compared to G3. Concentration of T3 and T4 was higher (P<0.05) in G1 than in G2 and G3. All carcass traits and meat composition were not affected significantly by treatments. Economic feed efficiency was the best in G1, followed by G2, and the lowest in G3. In conclusion, treatment of weaned rabbits during growing period under summer ambient temperature from 5 to 13 weeks of age with green tea in combination with royal jelly or propolis twice/week resulted in improving growth performance, viability rate and economic feed efficiency without adversely effects on rabbit health, in particular, at 5-9 wk age interval. A combination of royal jelly with green tea showed the best r...

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Royal Jelly Increases High Density Lipoprotein Levels but in Older Patients Only

Cited by 9 publications

References 7 publications

Impact of royal jelly to improve reproductive performance of male rabbits under hot summer conditions

Impact of royal jelly to improve reproductive performance of male rabbits under hot summer conditions

Royal Jelly and Its Components Promote Healthy Aging and Longevity: From Animal Models to Humans

Effect of Some Natural Antioxidants on Growth Performance, Blood Parameters and Carcass Traits of Growing Rabbits Under Egyptian Summer Condition

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