Roxadustat as treatment for a blood transfusion-dependent maintenance hemodialysis patient: A case report and review of literature

Abstract

BACKGROUND Erythropoiesis-stimulating agents (ESAs) have revolutionized the therapeutic strategy for anemia in chronic kidney disease. However, some cases are resistant or hyporesponsive to ESAs. Roxadustat is an oral hypoxia-inducible factor-prolyl hydroxylase inhibitor that stimulates erythropoiesis and regulates iron metabolism. Here, we describe a hemodialysis patient with refractory anemia who did not respond to traditional treatments and depended on blood transfusion for more than 1 year. After applying Roxadustat, the patient’s anemia improved significantly. CASE SUMMARY A 44-year-old man was diagnosed with uremia accompanied by severe anemia with a hemoglobin (Hb) level ranging from 30-40 g/L. His anemia did not improve after sufficient dialysis or high doses of active ESAs; other causes of anemia were excluded. The patient required approximately 600-1000 mL of red blood cell suspension every 15-30 d for more than 1 year. After accepting Roxadustat therapy, the patient’s anemia symptoms improved significantly; his Hb level gradually increased to 50 g/L, and no further blood transfusions were administered. His Hb level reached 69 g/L by the 34 th week. Although a Hb level of 60-70 g/L cannot be considered satisfactory, he no longer required blood transfusions and his quality of life was substantially improved. Roxadustat showed good efficacy and safety in this case. CONCLUSION Roxadustat represents an innovative and effective agent for the clinical treatment of renal anemia caused by multiple complex factors.

Comparative Effect of Human Recombinant Erythropoietin and Roxadustat on Blood Pressure and Micro-Inflammatory Response in Hemodialysis Anemia

“…Roxadustat is an oral small-molecule hypoxia-inducible factor prolyl hydroxylase inhibitor drug, which can comprehensively regulate various factors that cause anemia, and can promote the level of endogenous erythropoietin and the absorption of iron, and the drug has a good corrective effect on the inhibition of erythropoiesis affected by inflammatory factors [9]. Roxadustat can significantly increase hemoglobin levels in the treatment of anemia in non-dialysis-dependent chronic kidney disease patients, which is more effective than placebo [10].…”

Comparative Effect of Human Recombinant Erythropoietin and Roxadustat on Blood Pressure and Micro-Inflammatory Response in Hemodialysis Anemia

“…Roxadustat is an oral small-molecule hypoxiainducible factor propyl hydroxylase inhibitor drug, which can comprehensively regulate various factors that cause anemia and can promote the level of endogenous EPO and the absorption of iron, and the drug has a good corrective effect on the inhibition of erythropoiesis affected by inflammatory factors [9] . Roxadustat can significantly increase hemoglobin levels in the treatment of anemia in non-dialysisdependent CKD patients, which is more effective than placebo [10] .…”