Równowaga Proteazowo-Antyproteazowa a Palenie Tytoniu

Kołodziejczyk, Joanna; Wojciechowska, Milena; Bartuzi, Zbigniew; Dziedziczko, A

doi:10.5603/arm.27661

Cited by 5 publications

(1 citation statement)

References 35 publications

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“…Wpływy środowiskowe obejmują przede wszystkim zanieczyszczenia występujące w otoczeniu człowieka, takie jak tlenek węgla i azotu, dwutlenek węgla, tlenek i dwutlenek siarki, środki ochrony roślin (pestycydy), cząstki pyłu zawieszonego oraz dym tytoniowy. Spośród nich, aktywne palenie oraz bierna ekspozycja na dym tytoniowy są postrzegane jako jedne z najważniejszych czynników w negatywny sposób wpływających na wentylacyjną funkcję płuc [7][8][9]. Trwają jednak poszukiwania nowych elementów istotnych dla rozwoju płuc w okresie najwcześniejszych etapów rozwoju osobniczego.…”

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Birth Weight as a Factor Determining Lung Function among Healthy Persons and Its Relation with Chronic Pulmonary Disease

Ichnowski¹,

Lindner²,

Pawłowicz³

et al. 2012

Advances in Respiratory Medicine

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Low lung function is associated with increased risk of morbidity and mortality in the population. Lung development seems to be important factor in pathogenesis of respiratory disorders. Airway development is a complex process. Birth weight (BW) is one of perinatal factors which influences development of pulmonary system and multiorgan function of the body. Aforementioned relationships are visible especially at first years of life. However, not very many studies have examined the associations between birth weight and lung function in later age then childhood and adolescence. The aim of this review is to discuss relationships between BW and lung function parameters in healthy individuals and patients with lung disease in childhood and adulthood.

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Section: Wstępunclassified

Birth Weight as a Factor Determining Lung Function among Healthy Persons and Its Relation with Chronic Pulmonary Disease

Ichnowski¹,

Lindner²,

Pawłowicz³

et al. 2012

Advances in Respiratory Medicine

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Alpha-1 Antitrypsin Antisense Oligonucleotide Modulates Protease-Antiprotease Imbalance without Further Aggravating Smoke-induced Lung Injury

Xiao

Stearns

Zelonina

et al. 2019

Preprint

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23Alpha-1 antitrypsin (AAT) is a serum protease inhibitor that prevents lung injury from 24 protease production during cigarette smoking but causes severe liver disease once mutated. A 25 custom AAT antisense oligonucleotide (ASO) was found to be beneficial for the AATD liver 26 disease by blocking the mutated AAT transcripts. Here we hypothesized that knock-down of AAT 27 aggravates murine lung injury during smoke exposure and acute exacerbations of chronic 28 obstructive pulmonary disease (COPD). C57BL/6J mice were randomly divided into 4 groups for 29 each of the injury models, smoking (inhale for 3 months at 150mg/m 3 ) and smoke-flu (inhale for 30 2 weeks and intranasal influenza virus). The ASO and control (No-ASO) were injected 31 subcutaneously at 10ml/kg of body weight, starting with smoking or four days prior to influenza 32 infection weekly at 50mg/kg. ASO treatment during a 3 month smoke exposure significantly 33 increased the expression of Cela1 mRNA and decreased the serum and lung AAT expression. 34 However, despite the decrease in AAT, neither the inflammatory cell counts in the bronchoalveolar 35 lavage fluid (BALF) nor the lung structural changes were significantly affected by ASO treatment. 36 We observed significant differences in inflammation and emphysema due to smoke exposure alone. 37 With the smoke-flu model, similarly the major differences were found between smoke-flu and 38 room air control, with no additional effect with ASO treatment. Off-target effects or compensatory 39 mechanisms may account for this finding. Alternatively, the reduction of AAT with ASO treatment 40 was not robust enough to lead to lung injury. The result also suggest that the AAT ASO approach 41 for treating liver disease is relatively safe at the specified dose as it did not lead to detrimental 42 outcomes in the lung. These potential mechanisms need to be further investigated in order to fully 43 understand the impact of AAT inhibition on protease-antiprotease imbalance in the murine smoke 44 exposure model. 45

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Activity ofα₁-Antitrypsin and Some Lysosomal Enzymes in the Blood Serum of Patients with Chronic Obstructive Pulmonary Disease after Smoking Cessation

Woźniak

Konca³

et al. 2015

BioMed Research International

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The activity of α 1-antitrypsin (AAT) and the lysosomal enzymes, cathepsin D (CTS D), arylsulfatase (ASA), and acid phosphatase, (AcP) was determined in patients with COPD (GOLD category A). Moreover, the diagnostic usefulness of these parameters in blood serum was assessed along with establishing whether smoking cessation affects these parameters. The study included 70 patients with COPD who ceased smoking (study group) and two control groups of 33 subjects each: nonsmokers without COPD (control I) and patients with COPD who continued smoking (control II). In control I, blood was taken once and in control II, at the start of the experiment and after the 1st, 2nd, and 3rd months. AAT in the patients exhibited higher activity than in the healthy subjects at all time points. AAT activity in the patients before the start of the experiment was ~80% higher (P < 0.001) than in control I. No statistically significant differences in CTS D, ASA, and AcP activity were found. COPD involves increased AAT activity and unchanged activities of the assessed lysosomal enzymes. Three-month tobacco abstinence does not affect these parameters in peripheral blood. Determining the AAT levels in blood serum can be used in the diagnostics of COPD.

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Równowaga Proteazowo-Antyproteazowa a Palenie Tytoniu

Cited by 5 publications

References 35 publications

Birth Weight as a Factor Determining Lung Function among Healthy Persons and Its Relation with Chronic Pulmonary Disease

Birth Weight as a Factor Determining Lung Function among Healthy Persons and Its Relation with Chronic Pulmonary Disease

Alpha-1 Antitrypsin Antisense Oligonucleotide Modulates Protease-Antiprotease Imbalance without Further Aggravating Smoke-induced Lung Injury

Activity ofα₁-Antitrypsin and Some Lysosomal Enzymes in the Blood Serum of Patients with Chronic Obstructive Pulmonary Disease after Smoking Cessation

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Równowaga Proteazowo-Antyproteazowa a Palenie Tytoniu

Cited by 5 publications

References 35 publications

Birth Weight as a Factor Determining Lung Function among Healthy Persons and Its Relation with Chronic Pulmonary Disease

Birth Weight as a Factor Determining Lung Function among Healthy Persons and Its Relation with Chronic Pulmonary Disease

Alpha-1 Antitrypsin Antisense Oligonucleotide Modulates Protease-Antiprotease Imbalance without Further Aggravating Smoke-induced Lung Injury

Activity ofα1-Antitrypsin and Some Lysosomal Enzymes in the Blood Serum of Patients with Chronic Obstructive Pulmonary Disease after Smoking Cessation

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Product

Resources

About

Activity ofα₁-Antitrypsin and Some Lysosomal Enzymes in the Blood Serum of Patients with Chronic Obstructive Pulmonary Disease after Smoking Cessation