Roux-Y Gastric Bypass and Sleeve Gastrectomy directly change gut microbiota composition independent of operation type

Paganelli, Fernanda L.; Luyer, Misha; Hazelbag, C. Marijn; Uh, Hae‐Won; Rogers, Malbert R. C.; Adriaans, Danielle; Berbers, Roos-Marijn; Hendrickx, Antoni P. A.; Viveen, Marco C.; Groot, James; Bonten, Marc J. M.; Fluit, Ad C.; Willems, Rob J. L.; Leavis, Helen L.

doi:10.1101/395657

Cited by 3 publications

(4 citation statements)

References 39 publications

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“…Verrucomicrobia and Bacteroidetes were the most variable in the healthy controls 51 . We and others 8,71 have also recently reported this large inter-individual variability in GM modulation post-BS.…”

Section: Inter-individual Microbial Modulationsupporting

confidence: 72%

Gut Microbiota Dysbiosis in Human Obesity: Impact of Bariatric Surgery

2019

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Purpose of the review: We herein summarize what is currently described in terms of Gut microbiota (GM) dysbiosis modification post-Bariatric surgery (BS) and their link with BSinduced clinical improvement. Noteworthy, we discuss how the major inter-individual variability in terms of GM changes could impact the variable clinical improvements seen in patients. Recent findings: The persisting increase in severe obesity prevalence has led to the subsequent burst in BS number. Indeed, it is to date the best treatment option to induce major and sustainable weight loss and metabolic improvement in these patients. During obesity, the gut microbiota (GM) displays distinctive features such as low microbial gene richness and compositional and functional alterations (termed dysbiosis) which have been associated with low-grade inflammation, increased body weight and fat mass, as well as type-2 diabetes. Interestingly, GM changes post-BS is currently being proposed as one the many mechanism explaining BS beneficial clinical outcomes. Summary: BS enables partial rescue of GM dysbiosis observed during obesity. Some of the GM characteristics modified post-BS (composition in terms of bacteria or functions) are linked to BS beneficial outcomes such as weight loss or metabolic improvements. Nevertheless the changes in GM post-BS display major variability from one patient to the other. Thus further large sample size studies associated with GM transfer studies in animals are still needed to completely decipher the role of GM in the clinical improvements observed post-surgery.

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Section: Inter-individual Microbial Modulationsupporting

confidence: 72%

Gut Microbiota Dysbiosis in Human Obesity: Impact of Bariatric Surgery

2019

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“…Finally, recent research has demonstrated that bariatric surgery induces an immediate and enduring modification of the gut microbiota, which is independent of the surgical procedure itself [102]. It has been suggested that changes in the gut microbiome can influence the pharmacokinetics of certain antiretrovirals, such as abacavir and dolutegravir [103].…”

Section: Bariatric or Metabolic Surgerymentioning

confidence: 99%

HIV Treatment and Obesity: What’s New?

Freitas,

Ribeiro

2024

Infectious Diseases

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Obesity among people living with human immunodeficiency virus (people living with human immunodeficiency virus (HIV) (PLWH)) is an emerging public health issue. In recent years, new drugs have been approved for the treatment of HIV infection, which have greatly extended the lives of patients, but they may also play a role in rising obesity rates. In addition to HIV-specific factors, traditional risk factors shared with the general population (aging, diet, inactivity, and genetics) are credible culprits for this pandemic. Importantly, the compounded presence of obesity and HIV infection seems to magnify the risk of metabolic disease. To date, several questions remain to be fully elucidated including the mechanisms by which antiretroviral drugs may lead to excessive weight gain, the influence of the interplay with environmental and genetic factors, and the long-term clinical effect of obesity in PLWH. Recently, new drugs for the treatment of obesity and new metabolic surgeries have emerged, shading new hope on obesity management. The aim of this chapter is to take a journey into the world of obesity, showing the most recent evidence in HIV patients.

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“…The extracted DNA, for both oral and fecal samples, was sequenced following the protocol described before (18). Briefly, a 469 bp amplicon encompassing the V3 and V4 hypervariable regions of the 16S rRNA gene was amplified and sequenced using the Illumina MiSeq Reagent Kit v3 2 × 300 bp (600-cycle) or the Illumina MiSeq Reagent Kit v2 2 × 250 bp (500-cycle) on a MiSeq Illumina sequencer according to Fadrosh et al (19).…”

Section: S Rrna Gene Sequencingmentioning

confidence: 99%

“…In order to have identical read lengths for all samples, reads from the 2 × 300 bp run were trimmed down to 250 bp to match the other dataset. All reads were pre-processed as described (18) and merged using FLASH (version 1.2.11) (20) with options "-t 1" and "-M 167." Subsequently, merged reads were de-multiplexed using the "split_libraries_fastq.py" script and further analyzed using the QIIME microbial community analysis pipeline (version 1.9.1) (21).…”

Section: Bioinformatic Data Analysismentioning

confidence: 99%

Behçet's Disease Under Microbiotic Surveillance? A Combined Analysis of Two Cohorts of Behçet's Disease Patients

et al. 2020

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Background: In Behçet's disease (BD), an auto-inflammatory vasculitis, an unbalanced gut microbiota can contribute to pro-inflammatory reactions. In separate studies, distinct pro-and anti-inflammatory bacteria associated with BD have been identified. Methods: To establish disease-associated determinants, we performed gut microbiome profiling in BD patients from the Netherlands (n = 19) and Italy (n = 13), matched healthy controls (HC) from the Netherlands (n = 17) and Italy (n = 15) and oral microbiome profiling in Dutch BD patients (n = 18) and HC (n = 15) by 16S rRNA gene sequencing. In addition, we used fecal IgA-SEQ analysis to identify specific IgA coated bacterial taxa in Dutch BD patients (n = 13) and HC (n = 8). Results: In BD stool samples alpha-diversity was conserved, whereas beta-diversity analysis showed no clustering based on disease, but a significant segregation by country of origin. Yet, a significant decrease of unclassified Barnesiellaceae and Lachnospira genera was associated with BD patients compared to HC. Subdivided by country, the Italian cohort displays a significant decrease of unclassified Barnesiellaceae and Lachnospira genera, in the Dutch cohort this decrease is only a trend. Increased IgA-coating of Bifidobacterium spp., Dorea spp. and Ruminococcus bromii species was found in stool from BD patients. Moreover, oral Dutch BD microbiome displayed increased abundance of Spirochaetaceae and Dethiosulfovibrionaceae families. Conclusions: BD patients show decreased fecal abundance of Barnesiellaceae and Lachnospira and increased oral abundance of Spirochaetaceae and Dethiosulfovibrionaceae. In addition, increased fecal IgA coating of Bifidobacterium, van der Houwen et al. Microbiota in Behçet's Disease Ruminococcus bromii and Dorea may reflect retention of anti-inflammatory species and neutralization of pathosymbionts in BD, respectively. Additional studies are warranted to relate intestinal microbes with the significance of ethnicity, diet, medication and response with distinct pro-and inflammatory pathways in BD patients.

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Roux-Y Gastric Bypass and Sleeve Gastrectomy directly change gut microbiota composition independent of operation type

Abstract: 26Background 27

Cited by 3 publications

References 39 publications

Gut Microbiota Dysbiosis in Human Obesity: Impact of Bariatric Surgery

Gut Microbiota Dysbiosis in Human Obesity: Impact of Bariatric Surgery

HIV Treatment and Obesity: What’s New?

Behçet's Disease Under Microbiotic Surveillance? A Combined Analysis of Two Cohorts of Behçet's Disease Patients

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