Patient: Male, 27Final Diagnosis: Obstructive gastric pseudotumorSymptoms: Dyspepsia • weight lossMedication: GanciclovirClinical Procedure: Infectious diseases treatments and surgical treatmentSpecialty: Gastroenterology and HepatologyObjective:Rare co-existance of disease or pathologyBackground:Cytomegalovirus (CMV) is a common opportunistic pathogen in patients with HIV. It is also a major cause of gastrointestinal ulcers in patients with acquired immunodeficiency syndrome (AIDS). CMV pseudotumor in the stomach is a rare cause of digestive tract obstruction.Case Report:In this study we report a male patient infected with HIV in 2002. In 2014 he evolved C3 stage AIDS with prepyloric gastric ulcer which provoked deformity and pseudotumoral aspect of the gastric outlet. Endoscopic biopsy confirmed CMV infection. He underwent Roux-en-Y gastroenteroanastomosis with good recovery.Conclusions:CMV infection should be considered as an agent in gastric lesions in HIV-infected patients. Roux-en-Y gastroenteroanastomosis is a surgical option for this group of patients, allowing improvements in quality of life and decreasing risks of perioperative complications.