Roux-en-Y Gastric Bypass as a Treatment for Hepatic Iron Overload: An Exploratory Study

Jesus, Rafael Nascimento de; Callejas, Guilherme Hoverter; Chaim, Felipe David Mendonça; Gestic, Martinho Antônio; Callejas-Neto, Francisco; Chaim, Élinton Adami; Cazzo, Everton

doi:10.1007/s11695-022-06103-y

Cited by 3 publications

(1 citation statement)

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“…generic elementary histological variables (steatosis, steatohepatitis, and fibrosis) without differentiating between specific profiles of steatosis or inflammation, for example. [10][11][12][13] A detailed characterization of the impact of WL on the histopathological aspects related to NAFLD and markers of insulin resistance (IR) may provide further insights into the pathophysiology related to the treatment of the disease and the dynamics of hepatic histological recovery after WL.…”

Section: Introductionmentioning

confidence: 99%

Impact of pre-operative weight loss on non-alcoholic fatty liver disease histopathology and insulin resistance in individuals undergoing bariatric surgery: a propensity matched cross-sectional comparison

Maldonado¹,

Mega

Germano

et al. 2024

Sao Paulo Med. J.

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BACKGROUND: The effect of weight loss (WL) on histopathological aspects of non-alcoholic fatty liver disease (NAFLD) may provide further insights into the dynamics of hepatic recovery after WL. OBJECTIVE: To analyze the effects of pre-operative WL on insulin resistance-and NAFLD-related histology in individuals undergoing bariatric surgery (BS) with or without pre-operative WL. DESIGN AND SETTING: A matched cross-sectional study was conducted at a public university hospital and a private clinic in Campinas, Brazil. METHODS: An analytical, observational, cross-sectional study was conducted using prospectively collected databases of individuals who underwent BS and liver biopsy at either a public tertiary university hospital (with pre-operative WL) or a private clinic (without pre-operative WL). Random electronic matching by gender, age, and body mass index (BMI) was performed and two paired groups of 24 individuals each were selected. RESULTS: Of the 48 participants, 75% were female. The mean age was 37.4 ± 9.6. The mean BMI was 38.9 ± 2.6 kg/m 2 . Fibrosis was the most common histopathological abnormality (91.7%). Glucose was significantly lower in the WL group (92 ± 19.1 versus 111.8 ± 35.4 mg/dL; P = 0.02). Significantly lower frequencies of macrovesicular steatosis (58.3% versus 95.8%; P = 0.004), microvesicular steatosis (12.5% versus 87.5%; P < 0.001), and portal inflammation (50% versus 87.5%; P = 0.011) were observed in the WL group. CONCLUSION: Pre-operative WL was significantly associated with lower frequencies of macro-and microvesicular steatosis, portal inflammation, and lower glycemia, indicating an association between the recent trajectory of body weight and histological aspects of NAFLD.

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Section: Introductionmentioning

confidence: 99%