Routine production of H11CN and [11C]-1-Aminocyclopentanecarboxylic acid

Sambre, J.; Vandecasteele, Carlo; Goethals, Patrick; Rabi, N. A.; Haver, Dirk Van; Slegers, Guido

doi:10.1016/0020-708x(85)90084-5

Cited by 22 publications

(8 citation statements)

References 3 publications

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“…199 Both unnatural amino acids 182 and natural ones have been prepared from [ 11 C]HCN, including [ 11 C- carbonyl ]tyrosine 200 and [ 11 C- carbonyl ]leucine (Fig. 7), 177 both of which are useful tools for imaging l -type amino acid transporter 1 (LAT1), protein synthesis in the brain, and gliomas.…”

Section: [11c]hcn Cyanationmentioning

confidence: 99%

¹¹CO bonds made easily for positron emission tomography radiopharmaceuticals

et al. 2016

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The positron-emitting radionuclide carbon-11 (11C, t1/2 = 20.3 minutes) possesses the unique potential for radiolabeling of any biological, naturally occurring, or synthetic organic molecule for in vivo positron emission tomography (PET) imaging. Carbon-11 is most often incorporated into small molecules by methylation of alcohol, thiol, amine or carboxylic acid precursors using [11C]methyl iodide or [11C]methyl triflate (generated from [11C]CO2). Consequently, small molecules that lack an easily substituted 11C-methyl group are often considered to have non-obvious strategies for radiolabeling and require a more customized approach. [11C]Carbon dioxide, [11C]carbon monoxide, [11C]cyanide, and [11C]phosgene represent alternative carbon-11 reactants to enable 11C-carbonylation. Methodologies developed for preparation of 11C-carbonyl groups have had a tremendous impact on the development of novel PET radiopharmaceuticals and provided key tools for clinical research. 11C-Carbonyl radiopharmaceuticals based on labeled carboxylic acids, amides, carbamates, and ureas now account for a substantial number of important imaging agents that have seen translation to higher species and clinical research of previously inaccessible targets, which is a testament to the creativity, utility, and practicality of the underlying radiochemistry.

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Section: [11c]hcn Cyanationmentioning

confidence: 99%

¹¹CO bonds made easily for positron emission tomography radiopharmaceuticals

et al. 2016

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“…For certain positron emission tomography radiotracers [ 11 C]cyanation is an attractive means of carbon‐11 incorporation, especially as the production of [ 11 C]CN − has become automated and more convenient. It has been used in the preparation of [ 11 C]‐labeled carboxylic acids and fatty acids, amino acids, various aromatic compounds, sugars, amines, and tetrazoles . The production of [ 11 C]CN − was first demonstrated in 1941 via the reduction of [ 11 C]CO 2 by potassium metal in the presence of ammonia in a sealed tube at 600 o C .…”

Section: Introductionmentioning

confidence: 99%

A modification to improve the reliability of [¹¹C]CN⁻ production in the GE radiochemistry system

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Nabulsi

et al. 2017

Labelled Comp Radiopharmac

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“…The reported target systems that yield high levels of 11 CH 4 have been large volumes (e.g. 40 cm long ϫ 6 cm diameter) and operated at pressures exceeding 10 atmospheres and proton energies above 18 MeV [4,17]. These conditions favor the production of CH 4 while minimizing the impact of recoil collisions with the target chamber walls due to the large diameters which exceeds the beam profile, even after multiple scattering is taken into account.…”

Section: Discussionmentioning

confidence: 99%