Routine pre-procedural rectal indometacin versus selective post-procedural rectal indometacin to prevent pancreatitis in patients undergoing endoscopic retrograde cholangiopancreatography: a multicentre, single-blinded, randomised controlled trial

Luo, Hui; Zhao, Lina; Leung, Joseph; Zhang, Rongchun; Liu, Zhiguo; Wang, Xiangping; Wang, Biaoluo; Nie, Zhilin; Lei, Ting; Li, Xun; Zhou, Wence; Zhang, Lingen; Wang, Qi; Li, Ming; Zhou, Yi; Liu, Qian; Sun, Haiyan; Wang, Zheng; Liang, Shuhui; Guo, Xiaotong; Qin, Tao; Wu, Kaichun; Pan, Yanglin; Guo, Xiaomao; Fan, Daiming

doi:10.1016/s0140-6736(16)30310-5

Cited by 178 publications

(146 citation statements)

References 38 publications

Supporting

Mentioning

134

Contrasting

Unclassified

Order By: Relevance

“…Multiple non-UK studies use indomethacin as the NSAID of choice when looking at its effectiveness in reducing PEP (eg, Levenick et al 7 and Luo et al 8). Mohammed Alizadeh et al 25 conducted a relatively small randomised study of 372 patients to assess the difference in effectiveness between rectal indomethacin, diclofenac and naproxen.…”

Section: Discussionmentioning

confidence: 99%

“…However, Levenick et al 7 performed a single-centre randomised study which showed that rectal indomethacin is not effective in reducing the rate of pancreatitis in consecutive patients, regardless of risk. Contrary to this, a multicentre randomised controlled trial by Luo et al 8 demonstrated that using rectal indomethacin in unselected patients reduced the risk of PEP. In the UK, there is little data regarding the effectiveness of rectal NSAIDs to reduce PEP after an ERCP.…”

Section: Introductionmentioning

confidence: 90%

See 1 more Smart Citation

Does rectal diclofenac reduce post-ERCP pancreatitis? A district general hospital experience

Sheiybani

Brydon

Toolan

et al. 2017

Frontline Gastroenterol

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 90%

Does rectal diclofenac reduce post-ERCP pancreatitis? A district general hospital experience

Sheiybani

Brydon

Toolan

et al. 2017

Frontline Gastroenterol

View full text Add to dashboard Cite

show abstract

“…A recent PRCT concluded that universal pre-ERCP RNSAID was superior to selective administration of RNSAID post-ERCP in only high-risk patients but the number needed to treat (NNT) was high = 25. 141 Overall, mostly average-risk patients were studied; a minority (23% overall) became high-risk due to difficult cannulation +/-need for precut. Overall, there was a statistically significant reduction of PEP for pre-ERCP RNSAID (4%) compared to the risk-stratified approach of post-ERCP RNSAID (8%) in which only the high-risk patients were treated.…”

Section: Post-ercp Prophylaxismentioning

confidence: 99%

Endoscopic retrograde cholangiopancreatography complications: Techniques to reduce risk and management strategies

Tarnasky

Kedia

2017

Int J Gastrointest Interv

View full text Add to dashboard Cite

Adverse events after endoscopic retrograde cholangiopancreatography (ERCP) are not uncommon and can be associated with tragic outcomes. Bleeding, perforation, and post-ERCP pancreatitis are the most common complications. Some events are unavoidable; others are associated with well described risk factors so that they can be either anticipated and/or measures can be taken for prevention or at least risk reduction. This review will focus on the more common complications after ERCP, their risk factors, and potential strategies for risk reduction. Additionally, recommendations for management of ERCP complications will be presented.

show abstract

“…Upper GI endoscopy research has also focused on reducing postendoscopy cancers 6 14. Evidence-based quality measures in endoscopic retrograde cholangiopancreatography (ERCP) include the use of rectal NSAIDS to reduce postprocedure pancreatitis15 and wire-guided cannulation 16…”

Section: Introductionmentioning

confidence: 99%

British society of gastroenterology Endoscopy Quality Improvement Programme (EQIP): overview and progress

Rees¹,

Koo²,

Anderson

et al. 2019

Frontline Gastroenterol

View full text Add to dashboard Cite

High quality gastrointestinal (GI) endoscopy improves patient care. Raising standards in endoscopy improves diagnostic accuracy, management of pathology and ultimately improves outcomes. Historical identification of significant variation in colonoscopy quality led to the development of the Joint Advisory Group (JAG) on GI Endoscopy, the Global Rating Scale (GRS), JAG Endoscopy Training System (JETS) training and certification. These measures led to major improvements in UK endoscopy but significant variation in practice still exists. To improve quality further the British Society of Gastroenterology Endoscopy Quality Improvement (EQIP) has been established with the aim of raising quality and reducing variation in the quality of UK endoscopy. A multifaceted approach to quality improvement (QI) will be undertaken and is described in this manuscript. Upper GI EQIP will support adoption of standards alongside regional upskilling courses. Lower GI EQIP will focus on supporting endoscopists to achieve current standards alongside approaches to reducing postcolonoscopy colorectal cancer rates. Endoscopic retrograde cholangiopancreatography EQIP will adopt a regional approach of using local data to support network-based QI. Newer areas of endoscopy practice such as small bowel endoscopy and endoscopic ultrasound will focus on identifying key performance indicators as well as standardising training and accreditation pathways. EQIP will also support QI in management of GI bleeding as well as standardising the approach to new techniques and technologies. Where evidence is lacking, approaches to gather new evidence and support the translation into clinical practice will be supported.

show abstract

Routine pre-procedural rectal indometacin versus selective post-procedural rectal indometacin to prevent pancreatitis in patients undergoing endoscopic retrograde cholangiopancreatography: a multicentre, single-blinded, randomised controlled trial

Cited by 178 publications

References 38 publications

Does rectal diclofenac reduce post-ERCP pancreatitis? A district general hospital experience

Does rectal diclofenac reduce post-ERCP pancreatitis? A district general hospital experience

Endoscopic retrograde cholangiopancreatography complications: Techniques to reduce risk and management strategies

British society of gastroenterology Endoscopy Quality Improvement Programme (EQIP): overview and progress

Contact Info

Product

Resources

About