Routine monitoring of carbamazepine and carbamazepine-10,11-epoxide in plasma by high-performance liquid chromatography using 10-methoxycarbamazepine as internal standard

Elyas, A.A.; Ratnaraj, Neville; Goldberg, Valerie D.; Lascelles, P. T.

doi:10.1016/s0378-4347(00)80512-5

Cited by 35 publications

(11 citation statements)

References 16 publications

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“…In this study most (279 of 322) plasma concentrations were below that value 2. Correlation of plasma concentrations obtained by EMIT with those obtained by more specific analytical methods is good (Elyas et al 1982).…”

Section: Discussionmentioning

confidence: 73%

Steady-State Carbamazepine Plasma Concentration-Dose Ratios in Epileptic Patients

Sánchez

Durán

Serrano

1986

Clinical Pharmacokinetics

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The distribution of carbamazepine plasma concentration-dose ratio was studied in 322 samples from patients undergoing long term treatment. Data have been grouped according to: age--3 to 6, 7 to 9, 10 to 14, and above 15 years old; number of drugs used in the treatment--mono- and polytherapy; dose--less than or equal to 10, 10.1 to 14.9, 15 to 19.9, and greater than or equal to 20 mg/kg; and plasma concentration found--less than 4, 4 to 8, 8.1 to 12, and greater than 12 mg/L. From the results it is concluded that the carbamazepine concentration-dose ratio increases with age in children, but is less than in adults, is higher in monotherapy than in polytherapy, and decreases as the dose increases.

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Section: Discussionmentioning

confidence: 73%

Steady-State Carbamazepine Plasma Concentration-Dose Ratios in Epileptic Patients

Sánchez

Durán

Serrano

1986

Clinical Pharmacokinetics

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“…The serum concentrations of CBZ in three of the five volunteers were not within the therapeutic range after 1 week but were in the lower region of the therapeutic range of 3-12 ,ug ml-' by the end of the second week (Elyas et al, 1982). It is unlikely that maximal induction had occurred since CBZ undergoes dose-dependent induction (Rapeport et al, 1983).…”

Section: Discussionmentioning

confidence: 99%

The effect of carbamazepine on valproic acid disposition in adult volunteers.

Panesar

Orr

Farrell

et al. 1989

Brit J Clinical Pharma

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1 Pharmacokinetic parameters for valproic acid (VPA) were determined before and following 2 weeks of carbamazepine (CBZ) administration in five healthy male volunteers. Mean VPA dosage was 16.4 mg kg-1 day-1. CBZ dosage was started at 100 mg twice daily and increased after 1 week to a total daily dose of 300 mg. 2 After CBZ administration, mean VPA plasma clearance increased from 0.90 ± 0.18 s.d. to 1.26 ± 0.241 h-1 (P < 0.05) as did clearance of free VPA (20.8 ± 7.6 to 37.0 ± 13.6 1 h-1). Mean VPA elimination rate constant increased from 0.051 ± 0.011 to 0.067 + 0.011 h-1 (P < 0.05) after CBZ administration.3 Mean area under the serum concentration vs time curve decreased from 675.0 ± 130.5 to 475.7 ± 75.7 mg 1-1 h (P < 0.05) after CBZ administration. Mean serum VPA half-life decreased from 14.0 ± 2.4 to 10.6 ± 1.4 h (P < 0.05). Mean serum VPA trough concentrations decreased from 44.0 ± 16.7 to 27.0 ± 10.4 ,ug ml-' (P < 0.05).4 A significant change was not observed in the mean VPA volume of distribution after CBZ coadministration suggesting that enzyme induction rather than a competition for plasma protein binding sites was involved in this interaction. 5 Despite the increased clearance of VPA, the urinary recovery of VPA or conjugate did not increase after CBZ administration.

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“…Measurements of total and free PHT and total CBZ were made by enzyme immunoassay (EMIT) (Anonymous, 1982), and VPA and PB were measured by polarization fluoroimmunoassay (Lu-Steffes et al, 1982;Anonymous, 1984). Total and free carbamazepine-l0,ll-epoxide (CBZ-E) and free CBZ concentrations were measured by highperformance liquid chromatography (HPLC) (Elyas et al, 1982), and ESM was measured by gas chromatography (Latham and Macpherson, 1974).…”

Section: Methodsmentioning

confidence: 99%

Effects of Discontinuation of Phenytoin, Carbamazepine, and Valproate on Concomitant Antiepileptic Medication

Duncan¹,

Patsalos²,

Shorvon³

1991

Epilepsia

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We report a prospective, controlled study of the effects of the reduction and discontinuation of phenytoin (PHT) (22 patients), carbamazepine (CBZ) (23 patients), and valproate (VPA) (25 patients) with concomitant antiepileptic drugs (AEDs). The principal changes in the serum concentrations of concomitant AEDs were (a) phenobarbital (PB) concentrations decreased by a mean of 30% on discontinuation of PHT; (b) total CBZ concentrations increased by a mean of 48% and free CBZ concentrations increased by a mean of 30% on discontinuation of PHT, with no change in CBZ-10, 11-epoxide (CBZ-E) concentrations; (c) VPA concentrations increased by a mean of 19% on discontinuation of PHT; (d) VPA concentrations increased by a mean of 42% on discontinuation of CBZ; (e) ethosuximide (ESM) concentrations increased by a mean of 48% on discontinuation of CBZ; (f) PHT concentrations decreased by a mean of 26% on discontinuation of CBZ; (g) PHT free fraction decreased from a mean of 0.11 to 0.07 on discontinuation of VPA; and (h) the mean concentrations of total and free CBZ increased by a mean of 10 and 16%, respectively, on VPA discontinuation, with a concomitant mean 24% decrease in total CBZ-E and a 22% decrease in free CBZ-E. Apart from the decrease in PB concentrations on PHT discontinuation, all significant changes had occurred by 1 week after the end of AED discontinuation. The implication for clinical practice is that a serum AED concentration at this time reflects the new steady state. Free concentrations did not add any clinically useful information to that gained from analysis of total serum concentrations.

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Routine monitoring of carbamazepine and carbamazepine-10,11-epoxide in plasma by high-performance liquid chromatography using 10-methoxycarbamazepine as internal standard

Cited by 35 publications

References 16 publications

Steady-State Carbamazepine Plasma Concentration-Dose Ratios in Epileptic Patients

Steady-State Carbamazepine Plasma Concentration-Dose Ratios in Epileptic Patients

The effect of carbamazepine on valproic acid disposition in adult volunteers.

Effects of Discontinuation of Phenytoin, Carbamazepine, and Valproate on Concomitant Antiepileptic Medication

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