Routine laboratory biomarkers used to predict Gram-positive or Gram-negative bacteria involved in bloodstream infections

Abstract

This study evaluated routine laboratory biomarkers (RLB) to predict the infectious bacterial group, Gram-positive (GP) or Gram-negative (GN) associated with bloodstream infection (BSI) before the result of blood culture (BC). A total of 13,574 BC of 6787 patients (217 BSI-GP and 238 BSI-GN) and 68 different RLB from these were analyzed. The logistic regression model was built considering BSI-GP or BSI-GN as response variable and RLB as covariates. After four filters applied total of 320 patients and 16 RLB remained in the Complete-Model-CM, and 4 RLB in the Reduced-Model-RM (RLB p > 0.05 excluded). In the RM, only platelets, creatinine, mean corpuscular hemoglobin and erythrocytes were used. The reproductivity of both models were applied to a test bank of 2019. The new model presented values to predict BSI-GN of the area under the curve (AUC) of 0.72 and 0.69 for CM and RM, respectively; with sensitivity of 0.62 and 0.61 (CM and RM) and specificity of 0.67 for both. These data confirm the discriminatory capacity of the new models for BSI-GN (p = 0.64). AUC of 0.69 using only 4 RLB, associated with the patient's clinical data could be useful for better targeted antimicrobial therapy in BSI.

Bacterial distribution and predictive value of blood routine parameters in elderly patients with bacteremia: a cross-sectional study

“…These findings align with prior research conducted by Guarno et al [7] . Similarly, an investigation by Daniela Dambroso et al [8] indicated that 47.7% of bloodstream infections were due to Gram-positive bacteria and 52.3% to Gram-negative bacteria, with the Enterobacteriaceae family, particularly E. coli (26.5%) andK. pneumoniae (19.7%), being the most prevalent.…”

Development and validation of a nomogram for predicting gram-negative bacterial infections in patients with peritoneal dialysis-associated peritonitis

“…Another element influencing GNB infections is hemoglobin. Previous research has demonstrated a correlation between greater hemoglobin and a higher prevalence of GNB infections [ 26 ].…”

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