Routine endoscopic screening for synchronous esophageal neoplasm in patients with head and neck squamous cell carcinoma: a prospective study

Gong, Eun Jeong; Kim, D. H.; Jy, Ahn; Choi, Kyeong‐Hee; Jung, Kee Wook; Lee, J. H.; Song, Ho June; Lee, G. H.; Jung, Hwoon Yong; Kim, J. H.; Roh, Jong–Lyel; Choi, Seung‐Ho; Nam, Soon Yuhl; Kim, S. Y.

doi:10.1111/dote.12404

Cited by 28 publications

(45 citation statements)

References 35 publications

(136 reference statements)

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“…Two did not provide complete data to calculate sensitivity, specificity, and accuracy values in either the per-patient or per-lesion analysis [7, 20]. In one, the examinations were performed by inexperienced endoscopists [8]; and in another, the data were collected retrospectively [21].…”

Section: Resultsmentioning

confidence: 99%

Narrow band imaging versus lugol chromoendoscopy to diagnose squamous cell carcinoma of the esophagus: a systematic review and meta-analysis

et al. 2017

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BackgroundIn the early stage esophageal cancer, changes in the mucosa are subtle and pass unnoticed in endoscopic examinations using white light. To increase sensitivity, chromoscopy with Lugol’s solution has been used. Technological advancements have led to the emergence of virtual methods of endoscopic chromoscopy, including narrow band imaging (NBI). NBI enhances the relief of the mucosa and the underlying vascular pattern, providing greater convenience without the risks inherent to the use of vital dye. The purpose of this systematic review and meta-analysis was to evaluate the ability of NBI to diagnose squamous cell carcinoma of the esophagus and to compare it to chromoscopy with Lugol’s solution.MethodsThis systematic review included all studies comparing the diagnostic accuracy of NBI and Lugol chromoendoscopy performed to identify high-grade dysplasia and/or squamous cell carcinoma in the esophagus. In the meta-analysis, we calculated and demonstrated sensitivity, specificity, and positive and negative likelihood values in forest plots. We also determined summary receiver operating characteristic (sROC) curves and estimates of the areas under the curves for both per-patient and per-lesion analysis.ResultsThe initial search identified 7079 articles. Of these, 18 studies were included in the systematic review and 12 were used in the meta-analysis, for a total of 1911 patients. In per-patient and per-lesion analysis, the sensitivity, specificity, and positive and negative likelihood values for Lugol chromoendoscopy were 92% and 98, 82 and 37%, 5.42 and 1.4, and 0.13 and 0.39, respectively, and for NBI were 88 and 94%, 88 and 65%, 8.32 and 2.62, and 0.16 and 0.12, respectively. There was a statistically significant difference in only specificity values, in which case NBI was superior to Lugol chromoendoscopy in both analyses. In the per-patient analysis, the area under the sROC curve for Lugol chromoendoscopy was 0.9559. In the case of NBI, this value was 0.9611; in the per-lesion analysis, this number was 0.9685 and 0.9587, respectively.ConclusionsNBI was adequate in evaluating the esophagus in order to diagnose high-grade dysplasia and squamous cell carcinoma. In the differentiation of those disorders from other esophageal mucosa alterations, the NBI was shown to be superior than Lugol.

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Section: Resultsmentioning

confidence: 99%

Narrow band imaging versus lugol chromoendoscopy to diagnose squamous cell carcinoma of the esophagus: a systematic review and meta-analysis

et al. 2017

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“…Reasons for exclusion of other studies are mentioned in Figure . Review of the 96 screening studies resulted in the selection of 23 Lugol chromoendoscopy screening studies (Table ) . Most other screening studies were performed with only white‐light endoscopy (eg, triple‐endoscopy) or with the use of PET/CT.…”

Section: Resultsmentioning

confidence: 99%

“…The combined quality score of the MINORS and relevance criteria qualified 15 studies as medium or high quality and these were included in the present review . The remaining studies of low quality were excluded.…”

Section: Resultsmentioning

confidence: 99%

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Early detection of esophageal second primary tumors using Lugol chromoendoscopy in patients with head and neck cancer: A systematic review and meta‐analysis

et al. 2018

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Background Early detection of esophageal secondary primary tumors (SPTs) in head and neck squamous cell carcinoma (HNSCC) patients could increase patient survival. The purpose of this study was to determine the diagnostic yield of esophageal SPTs using Lugol chromoendoscopy. Methods A systematic review of all available databases was performed to find all Lugol chromoendoscopy screening studies. Results Fifteen studies with a total of 3386 patients were included. The average yield of esophageal‐SPTs in patients with HNSCC was 15%. The prevalence was the highest for patients with an index hypopharyngeal (28%) or oropharyngeal (14%) tumor. The esophageal‐SPTs were classified as high‐grade dysplasia in 49% of the cases and as invasive carcinoma's in 51%. Conclusion Our results show that 15% of the patients with HNSCC that underwent Lugol chromoendoscopy were diagnosed with an esophageal‐SPT. Based on these results there is enough evidence to perform Lugol chromoendoscopy, especially in an Asian patient population.

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“…We routinely performed endoscopic screening for upper gastrointestinal tract cancer in all patients with HSCC ( Figure 3). It has been demonstrated that routine endoscopic screening is effective for the early detection of oesophageal cancer, which in turn results in less invasive treatments such as endoscopic submucosal dissection (ESD) (11). Recent advances in narrow band imaging (NBI) and Lugol chromoendoscopy (LCE) have been particularly useful for the early detection of oesophageal cancer, which can then be treated by ESD (12).…”

Section: Discussionmentioning

confidence: 99%

Clinical and Prognostic Analysis of Hypopharyngeal Squamous Cell Carcinoma with Synchronous and Metachronous Multiple Malignancies

Yamamoto

Takano

Kondo

et al. 2018

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Abstract. Background Hypopharyngeal squamous cell carcinoma (HSCC) exhibits clinical manifestations that are different from other head and neck cancers. While it is less prevalent than other head and neck SCCs, accounting for 3-5% of all such malignancies, it carries a very poor prognosis (1-3). High mortality due to HSCC is caused not only by the high rates of nodal and early systemic metastases at presentation or during follow-up, but also the occurrence of second primary malignancies (SPMs) that are identified either simultaneously with the primary lesion (synchronous) or a period of time thereafter (metachronous). A recent study found that 17% of 2,063 patients with head and neck cancer involved SPMs, and that the overall survival rates of these patients were significantly lower than in those without SPMs (4). The head and neck, lung, and oesophagus are the most frequent areas of SPM development after an index head and neck cancer (4, 5). Many of the common risk factors for head and neck cancer, such as smoking, alcohol, aging, and poor oral hygiene, can increase the risk for SPM elsewhere in the body. Patients with HSCC in particular develop SPMs more frequently than those with other primary regions of head and neck cancer (5, 6); therefore, identifying the critical risk factors for this phenomenon is important for the earlier detection and prevention of multiple primary cancers. However, there have been few studies that focused on SPM in patients with HSCC. Hence, the present study aimed to analyse the clinical features and prevalence of synchronous and metachronous SPM in patients with HSCC, as well as to identify the risk factors associated with SPM occurrence and determine the causespecific mortality. Patients and MethodsPatients. A total of 136 patients (121 men and 15 women) with HSCC were diagnosed and treated between 2006 and 2015 at the

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Routine endoscopic screening for synchronous esophageal neoplasm in patients with head and neck squamous cell carcinoma: a prospective study

Cited by 28 publications

References 35 publications

Narrow band imaging versus lugol chromoendoscopy to diagnose squamous cell carcinoma of the esophagus: a systematic review and meta-analysis

Narrow band imaging versus lugol chromoendoscopy to diagnose squamous cell carcinoma of the esophagus: a systematic review and meta-analysis

Early detection of esophageal second primary tumors using Lugol chromoendoscopy in patients with head and neck cancer: A systematic review and meta‐analysis

Clinical and Prognostic Analysis of Hypopharyngeal Squamous Cell Carcinoma with Synchronous and Metachronous Multiple Malignancies

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