Routine elastin staining improves venous invasion detection in colorectal carcinoma

Bahmad, Hisham F.; Alloush, Ferial; Salami, Ali; Sawah, Rachel; Lusnia, Ciara; Kilinc, Ekim; Sutherland, Tyson; Alghamdi, Sarah; Poppiti, Robert J.

doi:10.1016/j.anndiagpath.2023.152170

Cited by 2 publications

(4 citation statements)

References 29 publications

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“…Furthermore, a statistically significant association was found between venous invasion detection via elastin staining and an elevated risk of hematogenous spread, decreased relapse-free survival, and reduced cause-specific survival [14]. Similarly, a study by our group yielded a rise in the venous invasion detection rate in the elastin-stained cohort (50.8%) compared to H&E staining alone (18.6%) [11]. Supporting these findings, a survey encompassing 361 Canadian pathologists documented a twofold increase in venous invasion detection upon the incorporation of elastin stains [12].…”

Section: The Use Of Elastin Stain In Colorectal Carcinomasupporting

confidence: 56%

“…In this regard, Messenger et al highlighted that the adoption of elastin stains for venous invasion identification in CRC led to decreased diagnostic time and a more streamlined utilization of blocks, ultimately contributing to a more efficient diagnostic process [28]. Similarly, we have shown in a recent study by our group that implementing routine elastin staining on all tumor-containing blocks, rather than on selected tumorcontaining blocks, increased the venous invasion detection rate in CRC [11].…”

Section: Elastin Stainmentioning

confidence: 52%

“…We particularly demonstrated that in instances where vessel distortion or obliteration was present, elastin staining exhibited superior performance. Our findings revealed a substantial enhancement in venous invasion detection rates, with Van Gieson's elastin staining associated with a notable 4.5-fold increase in venous invasion identification upon implementing routine staining on all tumor-containing blocks compared to H&E alone [11].…”

Section: Elastin Stainmentioning

confidence: 63%

“…Of note, the invasion into blood vessels assumes greater significance due to its correlation with an adverse prognosis, potentially facilitating the metastatic dissemination of the tumor to distant anatomical sites, whereas invasion into lymphatic vessels may potentially prompt lymph node involvement [9]. Extensive research underscores the correlation between the infiltration of blood vessels and/or lymphatics by tumors and unfavorable patient outcomes, particularly evident in cases of colorectal cancer (CRC) [10][11][12][13][14]. Overall, a prevailing consensus prevails: the presence of LVI is correlated with worse outcomes across various malignancies [7,[15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

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The Usefulness of Elastin Staining to Detect Vascular Invasion in Cancer

Gonzalez,

Bahmad,

Ocejo

et al. 2023

IJMS

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Tumor prognosis hinges on accurate cancer staging, a pivotal process influenced by the identification of lymphovascular invasion (LVI), i.e., blood vessel and lymphatic vessel invasion. Protocols by the College of American Pathologists (CAP) and the World Health Organization (WHO) have been established to assess LVI in various tumor types, including, but not limited to, breast cancer, colorectal cancer (CRC), pancreatic exocrine tumors, and thyroid carcinomas. The CAP refers to blood vessel invasion as “angioinvasion” (vascular invasion) to differentiate it from lymphatic vessel invasion (lymphatic invasion). For clarity, the latter terms will be used throughout this review. The presence of lymphatic and/or vascular invasion has emerged as a pivotal prognostic factor; therefore, its accurate identification is crucial not only for staging but also for providing the patient with an honest understanding of his/her prognosis. Given the prognostic importance of the correct identification of LVI, specific staining techniques are employed to distinguish lymphatic vessel invasion from angioinvasion and to differentiate true LVI from artifact. These encompass hematoxylin and eosin (H&E) staining, elastic staining, Factor VIII staining, Ulex europaeus I agglutinin staining, CD31, CD34, D2-40, ERG, and D2-40 (podoplanin) immunohistochemical (IHC) stains among others. Based on a review of numerous publications regarding the efficacy of various methods for LVI detection, elastin staining demonstrated superior accuracy and prognostic value, allowing for more targeted treatment strategies. The clinical significance of accurately detecting LVI cannot be overstated, as it is strongly linked to higher cancer-related mortality and an increased risk of tumor recurrence. This review aims to examine the existing literature on the use of elastin stains in the detection of vascular invasion among different types of tumors and its prognostic value.

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Section: The Use Of Elastin Stain In Colorectal Carcinomasupporting

confidence: 56%

Section: Elastin Stainmentioning

confidence: 52%

Section: Elastin Stainmentioning

confidence: 63%

Section: Introductionmentioning

confidence: 99%

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The Usefulness of Elastin Staining to Detect Vascular Invasion in Cancer

Gonzalez,

Bahmad,

Ocejo

et al. 2023

IJMS

Self Cite

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Pathological Extramural Venous Invasion in High-stage Urothelial Carcinoma of the Bladder has Shorter Locoregional Recurrence-free Survival

Mohamed,

Desai,

El-Habashy

et al. 2024

Int J Surg Pathol

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Extramural venous invasion is an independent prognostic factor in colorectal cancers; the pathological identification of extramural venous invasion in bladder cancer remains unclear. By focusing on high-stage urothelial carcinoma of the bladder, we provide insights into the pathological identification of extramural venous invasion in this particular clinical context. Clinical and demographic details and pathological reports were extracted from electronic medical records. Histological sections were reviewed for the pathological identification of extramural venous invasion. Statistical analysis was done using SPSS version 23 software. Survival analysis was done using Kaplan-Meier method. In patients with available follow-up data, 62% (n = 21) exhibited pathologically evidenced extramural venous invasion, whereas 38% (n = 13) did not. The extramural venous invasion positive group showed trends toward more advanced and pathological staging and a higher occurrence of extra-nodal extension. Positive margins were more frequent in the extramural venous invasion positive group (33%) compared to the extramural venous invasion negative group (8%). However, these differences were not statistically significant. Notably, all instances of recurrence were in the extramural venous invasion positive group of patients. The extramural venous invasion positive group of patients showed a significantly shorter locoregional recurrence-free survival ( P-value of 0.045). However, extramural venous invasion did not emerge as a significant factor in univariate analyses for recurrence-free survival. These findings highlight the potential role of extramural venous invasion as a prognostic factor in bladder cancer but underscore the need for further research with larger cohorts to confirm its significance.

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Routine elastin staining improves venous invasion detection in colorectal carcinoma

Cited by 2 publications

References 29 publications

The Usefulness of Elastin Staining to Detect Vascular Invasion in Cancer

The Usefulness of Elastin Staining to Detect Vascular Invasion in Cancer

Pathological Extramural Venous Invasion in High-stage Urothelial Carcinoma of the Bladder has Shorter Locoregional Recurrence-free Survival

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