Routes of administration of antibiotic prophylaxis for preventing infection after caesarean section

Nabhan, Ashraf; Allam, Nahed E; Salama, Mamdouh M.

doi:10.1002/14651858.cd011876

Cited by 7 publications

(2 citation statements)

References 33 publications

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“…Currently, no international guidelines advise the administration of pre-incision antibiotics according to risk stratification. However, other infection control measures also reduce infection risk in cesarean section, 21,40,41 and it may be valuable to investigate whether these measures would be adequate for infection prophylaxis for those at low risk of infection, or for patients concerned about the potential risks of IAP to the infant.…”

Section: Antib Iotic Prophyl a Xis For Ce Sare An S Ec Ti On: Current...mentioning

confidence: 99%

State of the art: Intrapartum antibiotics in cesarean section, the infant microbiota and allergic diseases

Moore

Navarro

McCarthy

et al. 2023

Acta Obstet Gynecol Scand

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International clinical guidelines for cesarean section recommend administration of prophylactic antibiotics prior to surgical incision for all cases to reduce the global burden of maternal infectious morbidity and mortality around the time of birth. 1,2 The timing is specified as pre-incision to allow therapeutic tissue levels to be obtained at the potential site of infection at the time of incision and for the duration of the procedure. 3 This differs from the previous practice of administering antibiotics after cord clamping. 2 The change came about following evidence that pre-incision antibiotics reduce the incidence of maternal infection without short-term adverse effects for the neonate. 4,5 With rising rates of cesarean section in many countries worldwide, 6,7 this protocol change results in more neonates being exposed to antibiotics prior to birth than ever before. While the short-term

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Section: Antib Iotic Prophyl a Xis For Ce Sare An S Ec Ti On: Current...mentioning

confidence: 99%

State of the art: Intrapartum antibiotics in cesarean section, the infant microbiota and allergic diseases

Moore

Navarro

McCarthy

et al. 2023

Acta Obstet Gynecol Scand

View full text Add to dashboard Cite

show abstract

“…Furthermore, the impact of post‐cesarean infections include additional cost, the use of therapeutic antibiotics, additional surgical interventions, longer duration of hospital stay and, in some cases, maternal death attributed to infection. A timely and appropriate regimen of prophylactic antibiotics, compared with placebo or no treatment, reduces the risk of post‐cesarean infections 7‐10 …”

Section: Antibiotic Prophylaxis For Cesarean Deliverymentioning

confidence: 99%

Contemporary issues in women’s health

Stringer

Nabhan

2021

Intl J Gynecology & Obste

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Routes of administration of antibiotic prophylaxis for preventing infection after caesarean section

Nabhan

Allam²,

Salama

2016

Cochrane Database of Systematic Reviews

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There was no clear difference between irrigation and intravenous antibiotic prophylaxis in reducing the risk of post-caesarean endometritis. For other outcomes, there is insufficient evidence regarding which route of administration of prophylactic antibiotics is most effective at preventing post-caesarean infections. The quality of evidence was very low to low, mainly due to limitations in study design and imprecision. Furthermore, most of the included studies were underpowered (small sample sizes with few events). Therefore, we advise caution in the interpretation and generalisability of the results.For future research, there is a need for well-designed, properly-conducted, and clearly-reported RCTs. Such studies should evaluate the more recently available antibiotics, elaborating on the various available routes of administration, and exploring potential neonatal side effects of such interventions.

show abstract

Routes of administration of antibiotic prophylaxis for preventing infection after caesarean section

Cited by 7 publications

References 33 publications

State of the art: Intrapartum antibiotics in cesarean section, the infant microbiota and allergic diseases

State of the art: Intrapartum antibiotics in cesarean section, the infant microbiota and allergic diseases

Contemporary issues in women’s health

Routes of administration of antibiotic prophylaxis for preventing infection after caesarean section

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