Route of Arsenic Exposure Differentially Impacts the Expression of Genes Involved in Gut-Mucosa-Associated Immune Responses and Gastrointestinal Permeability
Abstract:First-pass metabolism alters arsenic biotransformation and its immunomodulatory activities. This study aims to determine the mRNA expression of intestinal-immunity- and permeability-associated genes, levels of cytokine/chemokines and levels of immunoglobulin isotypes when CD-1 mice were exposed to a single dose of intravenous (IV) sodium arsenite (50 µg/kg body weight (BW)) and to compare these responses to exposure via oral gavage (OG) (50 µg/kg BW). Samples were collected at 1, 4, 24 and 48 h post IV exposur… Show more
“…Recent research has elucidated the mechanisms underlying leaky gut syndrome, including the dysregulation of tight junction proteins, mucosal inflammation, and dysbiosis of the gut microbiota [ 26 ], yet the external agents triggering leaky gut syndrome are not completely understood. Several studies show that environmental toxins such as arsenic can be an important modulator of gut-mucosa-associated immune responses and gastrointestinal permeability [ 27 ], opening up potential approaches to restore intestinal homeostasis.…”
The immune system plays a key role in gastrointestinal (GI) pathologies, being responsible for protecting the body against infection, maintaining homeostasis, and regulating the inflammatory response in the GI tract [...]
“…Recent research has elucidated the mechanisms underlying leaky gut syndrome, including the dysregulation of tight junction proteins, mucosal inflammation, and dysbiosis of the gut microbiota [ 26 ], yet the external agents triggering leaky gut syndrome are not completely understood. Several studies show that environmental toxins such as arsenic can be an important modulator of gut-mucosa-associated immune responses and gastrointestinal permeability [ 27 ], opening up potential approaches to restore intestinal homeostasis.…”
The immune system plays a key role in gastrointestinal (GI) pathologies, being responsible for protecting the body against infection, maintaining homeostasis, and regulating the inflammatory response in the GI tract [...]
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