Autonomous System (AS) business relationship data serves as an important trust foundation for detecting route leaks. Some AS's reluctant to disclose all of their business relationship data for various reasons has led to a decrease in routing detection accuracy, requiring AS business relationship prediction. The existing AS business relationship prediction schemes have problems with data tampering and the accuracy needs to be improved. This article proposes a trusted AS business relationship prediction method based on neural networks. By collecting and storing AS business relationship data on the blockchain, a feature library of AS business relationship data is constructed. Finally, a deep neural network is used for AS business relationship prediction to achieve reliable and accurate AS business relationship prediction.