Rous Sarcomas in Chickens: Enhanced Growth Coexisting with Concomitant Immunity

McBride, Raymond A.; Watanabe, Daniel H.; Schierman, Louis W.

doi:10.1126/science.196336

Cited by 10 publications

(12 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, in neither of these latter two experiments did a second inoculation with RSV influence the growth of the initial tumor. These results are in contrast to those of McBride et al (1977) who found that primary tumor growth was enhanced following a second inoculation with RSV.…”

Section: Effect Of B Genotype Oncontrasting

confidence: 85%

“…Immunity (as measured by resistance to induction of a second tumor) developed earlier in the regressor line, but by 15 days postinoculation (PI), chickens of both lines resisted a second challenge of either virus or tumor homogenate. McBride et al (1977) extended those findings to line G-Bl which is homozygous for the r-Rs-1 gene for progressive tumor growth (Schierman et al, 1977). All G-Bl chickens tested were resistant to a second challenge of RSV on the 8th day following primary inoculation.…”

Section: Introductionmentioning

confidence: 90%

“…The results for B s IB S animals (progressors) are in contrast to those of Gyles et al (1977) who found that when inoculation with RSV in the right wing followed RSV inoculation in the left wing by 15 days, all animals studied in a regressor line and virtually all in a progressor line resisted development of the second tumor. McBride et al (1977), using Sera from six B 2 IB 1 and nine B 5 IB 5 uninoculated animals served as controls.…”

Section: Effect Of B Genotype Onmentioning

confidence: 99%

“…(1977), studying F 2 segregants of across between two inbred lines of chickens which differed with respect to MHC antigens, showed that the percentages of animals with terminal sarcomas were, according to B genotype, B 5 /B s (95%), B 2 IB S (26%), and B 2 IB 1 (5%). Schierman et al (1977) showed that regression of Rous sarcoma virus-induced tumors was inherited as a dominant trait coded for by a gene within, or closely linked to, the B region of the MHC. The dominant allele for tumor regression was designated R-Rs-1; the recessive allele for progressive tumor growth in homozygous animals, r-Rs-1.…”

Section: Introductionmentioning

confidence: 98%

“…In the present communication, the method of McBride et al (1977) was used to assess antitumor immunity and/or enhancement of tumor growth in B 2 IB 2 and B* IB 5 progeny resulting from crosses between two highly inbred lines. Most B 2 IB 2 hosts resisted development of tumor after the second RSV challenge, but all B s /B s hosts developed tumors after both challenges.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Major Histocompatibility Complex (B): Effect on the Response of Chickens to a Second Challenge with Rous Sarcoma Virus

et al. 1982

View full text Add to dashboard Cite

The influence of B genotype on the formation of a second RSV-induced tumor was studied. Line 6(3) (B2/B2) and (6(1) x 15(1))F3 and F4 B2/B2 and B5/B5 chickens were challenged with RSV in the left wingweb at 6 weeks of age. Tumor-bearing animals then were rechallenged with RSV in the right wingweb at either 10, 11, or 12 days post primary inoculation. Most B2/B2 hosts resisted development of a second tumor compared to none of the B5/B5 hosts. Failure of a second tumor to develop in B2/B2 hosts was not explained by humoral neutralization of RSV in vivo, since sera from 83% of B2/B2 and 100% of B5/B5 tumor bearing chickens failed to neutralize virus prior to 12 days post primary inoculation. Humoral antiviral immunity appeared later in B5/B5 than in B2/B2 hosts. Humoral antiviral immunity appears to play little if any role in resistance to early RSV-induced tumor development, but likely both humoral and cell-mediated antitumor immunity do.

show abstract

Section: Effect Of B Genotype Oncontrasting

confidence: 85%

Section: Introductionmentioning

confidence: 90%

Section: Effect Of B Genotype Onmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Major Histocompatibility Complex (B): Effect on the Response of Chickens to a Second Challenge with Rous Sarcoma Virus

et al. 1982

View full text Add to dashboard Cite

show abstract

Increased growth of Rous sarcomas in chickens pretreated with formalinized syngeneic tumor cells

1977

View full text Add to dashboard Cite

The effect of inoculating formalinized syngeneic or allogeneic Rous sarcoma cells on the growth of Rous sarcoma virus (RSV)-induced tumors in two related inbred strains of chickens was studied. Chickens from both strains that received three weakly inoculations of syngeneic tumor cells had a significant increase in tumor growth and mortality after subsequent challenge with RSV. Development of RSV-induced tumors in chickens pretreated with formalinized allogeneic tumor cells (i.e. incompatible for major histocompatibility complex (MHC) antigens) was similar to what we observed in nonpretreated control chickens. The finding that the tumor-host relationship is altered only in chickens pretreated with formalinized syngeneic RSV-transformed cells, suggests that tumor-associated antigens of Rous sarcomas are modified MHC antigens analogous to "altered self" antigens thought to be present on certain virus-infected cells. If this hypothesis is correct, the results we obtained with formalin-killed syngeneic tumor cells can be explained on the basis of three possible mechanisms: immunological enhancement, immune tolerance or induction of antibody to anti-tumor idiotype. The merits of each mechanism in accounting for the results are discussed.

show abstract

Role of B cells in the expression of genetic resistance to growth of Rous sarcoma in the chicken

1978

View full text Add to dashboard Cite

Resistance to the development of progressively growing tumors induced by Rous sarcoma virus is a dominant trait controlled by a gene linked to the major histocompatibility complex (MHC). The effect of bursectomy (Bx) on the expression of this trait was studied in two inbred lines of chickens homozygous for different MHC alleles, and which differ with respect to the gene controlling resistance to Rous tumors. The results show that Bx alters the expression of the trait, since genetically resistant birds were rendered highly susceptible to progressive tumor growth. The bursa of Fabricius thus makes an important contribution to resistance. The results do not indicate whether genetic resistance is mediated exclusively by B cells or by another bursa-dependent population.

show abstract

Rous Sarcomas in Chickens: Enhanced Growth Coexisting with Concomitant Immunity

Cited by 10 publications

References 21 publications

Major Histocompatibility Complex (B): Effect on the Response of Chickens to a Second Challenge with Rous Sarcoma Virus

Major Histocompatibility Complex (B): Effect on the Response of Chickens to a Second Challenge with Rous Sarcoma Virus

Increased growth of Rous sarcomas in chickens pretreated with formalinized syngeneic tumor cells

Role of B cells in the expression of genetic resistance to growth of Rous sarcoma in the chicken

Contact Info

Product

Resources

About