Rourinoside and rouremin, antimalarial constituents from Rourea minor

Triterpene Saponins from <i>Clethra barbinervis</i> and Their Hyaluronidase Inhibitory Activities

“…3) In this paper, seven new saponins (1-4, 6-8) and a new lignan glucoside (14) were isolated from the extract of C. barbinervis, together with echinocystic acid 3-β-d-glucuronopyranoside (5), 4) hemsganoside B (9), 5,6) scheffleraside II (10), 5) rotundic acid (11), 7) barbinervic acid (12), 8) clethric acid (13), 9,10) 8-O-4′ neolignan 7-O-β-glucopyranoside (15), 11) rourinoside (16), 12) epicatechin (17), 13) pavetannin A (18), 14) 2-phenylethyl β-glucopyranoside (19), 15) 2-phenylethyl O-α-larabinofuranosyl-(1→ 6)-β-d-glucopyranoside (20), 16) 2-phenylethyl O-α-l-rhamnopyranosyl-(1→ 6)-β-d-glucopyranoside (21), 17) and methyl salicylate β-primeveroside (22) 18) (Figs. 1, 2).…”

Revisiting the linkage between ethnomedical use and development of new medicines: A novel plant collection strategy towards the discovery of anticancer agents

“…Although no bio-prospecting and isolation work from the Lao PDR has thus far proceeded to the stage of patent filing thereby meriting additional studies (unlike for Vietnam; Zhang et al, 2014Zhang et al, , 2017, through the VietnamLaos ICBG, six medicinal plant taxa from around the country have been evaluated through the compound isolation stage and have been found to contain mostly novel phytochemicals bearing anti-tuberculosis , anti-malarial (He et al, 2005(He et al, , 2006Libman et al, 2008;Ma et al, 2008); and cancer cell cytotoxicity activities (Zhang et al, 2004). With respect to anticancer bio-prospecting from the ICBG field work conducted from 1998 to 2012 in the Lao PDR, at least 34 species yielded 50 extracts with significant activity (IC 50 < 20 μg/ml) in one or more cancer cell lines of a six cell line panel, which notably led to the isolated compounds asparacoside and 3''-methoxy-nyasol (IC 50 > 4 μg/ml, < 10 μg/ml) from Asparagus cochinchinensis (Lour.)…”

Chemical constituents of Rourea doniana

“…, besides 9S,12S,13S-trihydroxy-10E-octadecenoic acid and β-sitosterol glucoside from R. minor (He et al, 2006); quinone (rapanone) and cianidine (leucopelargonidine) from R. santaloides (Ramiah et al, 1976a); flavonoids (quercetin, quercetin 3-O-β-Lrhamnopyranoside, hyperin, astilbin, kaempferol, and rutin), anthraquinone (physcion and erythroglaucin), triterpenes (23-hydroxybetulinic acid, ursolic acid and hederagenin), coumarin (daphnetin), phenylpropanoid derivative [nonacosyl (E)-ferulate], phytosteroids (β-sitosterol, β-sitosteryl-β-D-glucopyranoside), besides fatty acids, alkane, alcohol, and glyceryl derivative from R. microphylla (Jiang et al, 1990;Zhang et al, 2008), and flavonoids (quercetin, hyperin, quercetin 3-O-α-L-arabinofuranoside, and quercetin 3-O-β-D-xylopyranoside) from the leaves of R. induta (Kalegari, 2009). Thus, this work describes for the first time the occurrence of triterpenes (1-5), flavonol (6), coumarin (9), and four phytosteroids (7-8, 10-11) from the leaves and stems of R. doniana.…”

“…The fruits, seeds, or leaves of R. volubilis and R. glabra are poisonous and are used against wild dogs and coyotes in poisoned baits (Kalegari, 2009); leaves of R. minor that are used in chinese folk medicine to treat minor abrasions and lesions (He et al, 2006), and R. induta for treat rheumatism (Kalegari, 2009). Few species have been screened so far for their biological activities.…”

“…Few species have been screened so far for their biological activities. Among them are R. doniana Baker, which hexane extract from stems showed significant activity (LD50 12.1 μg/mL) against the fourth instar larvae and chlroform extract from the stems of R. minor showed in vitro activity against Plasmodium falciparum (He et al, 2006). Previous phytochemical investigations on Rourea species reported the occurrence of two glycoside derivatives (rourinoside and rouremin) and monoglyceryl derivative [1-(26-…”