Round window membrane permeability to golimumab in guinea pigs: A pilot study

Ghossaini, Soha N.; Liu, Jenny P.; Phillips, Brett E.

doi:10.1002/lary.24163

Cited by 9 publications

(2 citation statements)

References 29 publications

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“… Salt and Ma (2001) studied substance penetration through the RWM to the scala tympani perilymph, and noticed a substance concentration gradient from the bottom to helicotrema of the cochlea. Ghossaini et al. (2013) used golimumab, a TNF-α blocker, as a local delivery into the inner ear to assess the RWM permeability in guinea pigs.…”

Section: Morphological Basis Of Membranous Labyrinth Barriersmentioning

confidence: 99%

Advances in research on labyrinth membranous barriers

Sun

Wang

2015

Journal of Otology

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Integrity of the membranous labyrinth barrier system is of critical importance, which promotes inner ear homeostasis and maintains its features. The membranous labyrinth barrier system is divided into several subsets of barriers which, although independent from each other, are interrelated. The same substance may demonstrate different permeability characteristics through different barriers and under different conditions, while different substances can have different permeability features even in the same barrier under the same condition. All parts of the membranous labyrinth barrier structure, including their morphology, enzymes and channel proteins, and theirs permeability characteristics under various physiological and pathological conditions are reviewed in this paper. Infections, noise exposure, ototoxicity may all increase permeability of the barriers and lead to disturbances in inner ear homeostasis.

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Section: Morphological Basis Of Membranous Labyrinth Barriersmentioning

confidence: 99%

Advances in research on labyrinth membranous barriers

Sun

Wang

2015

Journal of Otology

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show abstract

“…185 Factors impacting the permeability of the round window include size, concentration, 186 solubility and electrical charge of the molecule being transported , 187 Juhn et al, 1989, Goycoolea and Lundman, 1997.However, round window permeability of 188 different molecular weight substancesdependsmore likely on thespecific pathway involved 189 for transmembrane transport(passive diffusion, facilitated diffusion, active transport or 190 phagocytosis) (Goycoolea, 2001)than on the molecular weight itself. Indeed, both low-191 molecular weight substances such as aminoglycoside antibiotics and corticosteroids (around 192 500 Da) and large molecules such as horseradish peroxidase (45 kDa) (Kim et al, 1990) 193 andgolimumab, a monoclonal antibody (150 kDa) (Ghossaini et al, 2013)were able to diffuse 194 through the round window. Conversely, albumin (70 kDa) was not able to crossthe round 195 windowunless itwas altered or in case of inflammation (Hamaguchi et al, 1988).…”

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confidence: 99%