Rottlerin suppresses growth of human pancreatic tumors in nude mice, and pancreatic cancer cells isolated from KrasG12D mice

Rottlerin inhibits cell growth and invasion via down-regulation of Cdc20 in glioma cells

“…Some studies showed that rottlerin inhibited cancer cell growth and induced apoptosis in a variety of human cancers [13, 14, 41, 42]. Moreover, rottlerin could suppress growth of human pancreatic tumors in nude mice [43, 44]. We also found that overexpression of Cdc20 enhanced glioma cell proliferation, whereas depletion of Cdc20 suppressed cell growth in glioma cells.…”

“…Lu et al reported that rottlerin induced LRP6 (LDL-receptor related protein 6) degradation and inhibited both Wnt/β-catherin and mTORC1 signaling in prostate and breast cancer cells [35]. Recently, it has been reported that rottlerin inhibited pancreatic tumor growth in nude mice [36]. Notably, rottlerin suppressed cell growth via the dual inhibition of ERK and NF-κB and downregulation of Cyclin D1 in melanoma cells [37].…”

Rottlerin exerts its anti-tumor activity through inhibition of Skp2 in breast cancer cells

“…One study identified that rottlerin stimulated cell apoptosis via interactions with proteins of the Bcl-2 family in pancreatic cancer cells [31]. Remarkably, rottlerin inhibited pancreatic cancer cell growth via targeting multiple signaling pathways including Akt, Notch, and Shh (sonic hedgehog) pathways [32]. Interestingly, Rottlerin was found to induce autophagy in several cancer cell lines [33].…”

Multiple mechanisms of Rottlerin toxicity in A375 melanoma cells

“…As Figure demonstrates, the rottlerin exposure led to a drop in cyclin D1 as early as after 2 hr. This rottlerin effect can be ascribed to the inhibition of the transcription factor Nuclear Factor Kappa B (NFκB), whose nuclear migration is prevented by rottlerin in a number of cells …”