Rotigotine for nocturnal hypokinesia in Parkinson's disease: Quantitative analysis of efficacy from a randomized, placebo-controlled trial using an axial inertial sensor

Bhidayasiri, Roongroj; Sringean, Jirada; Chaiwong, Suchapit; Anan, Chanawat; Penkeaw, Nuntiwat; Leaknok, Amarinee; Boonpang, Kamolwan; Saksornchai, Karn; Rattanachaisit, Watchara; Thanawattano, Chusak; Jagota, Priya

doi:10.1016/j.parkreldis.2017.08.010

Cited by 33 publications

(32 citation statements)

References 12 publications

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“…There were two papers detailing a case-control design whereby people with PD were directly compared to control participants when evaluating various parameters such as activity levels and keyboard typing metrics [29,30]. In two studies, technologies were being used in the home environment as outcome measures in clinical therapeutic trials [31,32] and a further four were randomised controlled trials or sub-studies thereof [33][34][35][36].…”

Section: Methodsmentioning

confidence: 99%

“…Sleep had been measured in 11 of the studies included in this systematic review [31,33,41,67,[89][90][91][92][93][94][95]. Wearable devices were used to measure sleep outcomes in all of these studies.…”

Section: Sleepmentioning

confidence: 99%

“…Multiple device platforms were described in three of the studies [90,93,94]; of note, Gros et al [90] were interested in quantifying apnoea, hypopnoea, oxygen desaturation and pulse rate using two respiratory inductance plethysmography belts, a nasal pressure cannula and a pulse oximeter. Accelerometers were used in all of the wearable devices, accompanied by gyroscopes in four papers (all using the 'NIGHT-Recorder' device to measure nocturnal hypokinesia) [31,33,93,94]. Validation had been attempted, if documented, in five studies, with the use of sleep diaries [31,33,93,94], polysomnography [92] and night-time video recordings [94] to provide ground truth.…”

Section: Sleepmentioning

confidence: 99%

“…Accelerometers were used in all of the wearable devices, accompanied by gyroscopes in four papers (all using the 'NIGHT-Recorder' device to measure nocturnal hypokinesia) [31,33,93,94]. Validation had been attempted, if documented, in five studies, with the use of sleep diaries [31,33,93,94], polysomnography [92] and night-time video recordings [94] to provide ground truth. Clinimetric properties are detailed in Table 2; however, there was a range of information about accuracy and agreement with clinical rating scales and questionnaires.…”

Section: Sleepmentioning

confidence: 99%

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Systematic Review Looking at the Use of Technology to Measure Free-Living Symptom and Activity Outcomes in Parkinson’s Disease in the Home or a Home-like Environment

Morgan

Rolinski

McNaney

et al. 2020

JPD

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Background: The emergence of new technologies measuring outcomes in Parkinson's disease (PD) to complement the existing clinical rating scales has introduced the possibility of measurement occurring in patients' own homes whilst they freely live and carry out normal day-today activities. Objective: This systematic review seeks to provide an overview of what technology is being used to test which outcomes in PD from free-living participant activity in the setting of the home environment. Additionally, this review seeks to form an impression of the nature of validation and clinimetric testing carried out on the technological device(s) being used. Methods: Five databases (Medline, Embase, PsycInfo, Cochrane and Web of Science) were systematically searched for papers dating from 2000. Study eligibility criteria included: adults with a PD diagnosis; the use of technology; the setting of a home or home-like environment; outcomes measuring any motor and non-motor aspect relevant to PD, as well as activities of daily living; unrestricted/unscripted activities undertaken by participants.

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Section: Methodsmentioning

confidence: 99%

Section: Sleepmentioning

confidence: 99%

Section: Sleepmentioning

confidence: 99%

Section: Sleepmentioning

confidence: 99%

See 2 more Smart Citations

Systematic Review Looking at the Use of Technology to Measure Free-Living Symptom and Activity Outcomes in Parkinson’s Disease in the Home or a Home-like Environment

Morgan

Rolinski

McNaney

et al. 2020

JPD

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“…Rotigotine has been reported to improve sleep quality [32]. The improvement in abnormal circadian rhythm might be attributed to an improvement in motor function [33] and enhancement of the patients’ sleep quality at night [34]. …”

Section: Discussionmentioning

confidence: 99%

Rotigotine Improves Abnormal Circadian Rhythm of Blood Pressure in Parkinson’s Disease

Oka

Nakahara

Umehara³

2018

Eur Neurol

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Introduction: Cardiovascular autonomic failure is commonly associated with Parkinson’s disease (PD), affecting the daily lives of patients. Rotigotine was recently reported not to influence cardiovascular autonomic responses in contrast to other dopaminergic drugs. The effect of rotigotine on daily blood pressure (BP) fluctuations might reflect autonomic failure in patients with PD. Methods: Twenty-five PD patients who were receiving rotigotine and 12 patients not receiving rotigotine were recruited. Systolic BP during the daytime and nighttime was measured by 24-h BP monitoring at an interval of 2 years. The patients were divided into 3 groups according to the BP fluctuation type: dippers (nocturnal fall in BP ≥10%), non-dippers (0–10%), and risers (< 0%). The time course of BP was compared between the patients given rotigotine and those not given rotigotine. Results: Among the 25 patients who received rotigotine, the BP type worsened in 2 patients, was unchanged in 16 patients, and improved in 7 patients. Among the 12 patients who were not receiving rotigotine, the BP type worsened in 5 patients, was unchanged in 4 patients, and improved only in 3 patients (p = 0.042). Conclusion: Rotigotine improves the abnormal circadian rhythm of BP in patients with PD. Rotigotine was suggested to have favorable effects on cardiovascular autonomic responses and circadian rhythm in patients with PD.

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Tossing and Turning in Bed: Nocturnal Movements in Parkinson's Disease

et al. 2020

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BackgroundSleep disturbances and nocturnal hypokinesia are common in Parkinson's disease (PD). Recent work using wearable technologies showed fewer nocturnal movements in PD when compared with controls. However, it is unclear how these manifest across the disease spectrum.ObjectivesWe assessed the prevalence of sleep disturbances and nocturnal hypokinesia in early and advanced PD and their relation to nonmotor symptoms and dopaminergic medication.MethodsA total of 305 patients with PD with diverse disease severity (Hoehn and Yahr [H&Y] stage 1 = 47, H&Y stage 2 = 181, H&Y stage 3 = 77) and 205 healthy controls continuously wore a tri‐axial accelerometer on the lower back for at least 2 days. Lying, turning, and upright ‐time at night were extracted from the acceleration signals. Percent upright time and nighttime walking were classified as sleep interruptions. The number, velocity, time, side, and degree of rotations in bed were used to evaluate nocturnal movements.ResultsNocturnal lying time was similar among all groups (healthy controls, 7.5 ± 1.2 hours; H&Y stage 1, 7.3 ± 0.9 hours; H&Y stage 2, 7.2 ± 1.3 hours; H&Y stage 3, 7.4 ± 1.6 hours; P = 0.501). However, patients with advanced PD had more upright periods, whereas the number and velocity of their turns were reduced (P ≤ 0.021). Recently diagnosed patients (<1 year from diagnosis) were similar to controls in the number of nocturnal turns (P = 0.148), but showed longer turning time (P = 0.001) and reduced turn magnitude (P = 0.002). Reduced nocturnal movements were associated with increased PD motor severity and worse dysautonomia and cognition and with dopaminergic medication.ConclusionsUsing wearable sensors for continuous monitoring of movement at night may offer an unbiased measure of disease severity that could enhance optimal nighttime dopaminergic treatment and utilization of turning strategies. © 2020 International Parkinson and Movement Disorder Society

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Rotigotine for nocturnal hypokinesia in Parkinson's disease: Quantitative analysis of efficacy from a randomized, placebo-controlled trial using an axial inertial sensor

Cited by 33 publications

References 12 publications

Systematic Review Looking at the Use of Technology to Measure Free-Living Symptom and Activity Outcomes in Parkinson’s Disease in the Home or a Home-like Environment

Systematic Review Looking at the Use of Technology to Measure Free-Living Symptom and Activity Outcomes in Parkinson’s Disease in the Home or a Home-like Environment

Rotigotine Improves Abnormal Circadian Rhythm of Blood Pressure in Parkinson’s Disease

Tossing and Turning in Bed: Nocturnal Movements in Parkinson's Disease

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