Rothia Bacteremia

Abstract

Background: The genus Rothia are nonmotile, aerobic or facultative anaerobic, non-spore-forming Gram-positive cocci, which are considered low-grade pathogens with relatively few known virulence determinants. Methods: During our retrospective, single-center cohort study, microbiological data were collected corresponding to the 12-year period (January 1, 200 to December 31, 2017), at the Institute of Clinical Microbiology, University of Szeged. Results: A total of 37 individual Rothia isolates were identified (3.1 ± 1.9/ years; range, 0-6 isolates), 28 were Rothia dentocariosa, 9 were Rothia mucilaginosa. The affected patients presented with a slight female dominance (21 of 37; female/male ratio, 1:31); the median age of the affected patients was 57 years (range, 1-86 years). In the majority of blood cultures (n = 22), Rothia species were the only isolated microorganisms. All of the tested strains were susceptible to benzylpenicillin, vancomycin, ciprofloxacin, moxifloxacin, linezolid, and rifampicin. Conclusions: Rothia species may readily be misidentified as staphylococci, streptococci, or corynebacteria, both the clinical microbiologists and physicians should be aware of the possible etiological role of these microorganisms during their clinical practice, especially if the relevant risk factors are present in these patients.

Rational Design of Phe‐BODIPY Amino Acids as Fluorogenic Building Blocks for Peptide‐Based Detection of Urinary Tract Candida Infections

“…In this context, urine samples are attractive clinical specimens due to their accessibility and direct relevance to urinary tract (UT) infections. The presence of Candida species in urine (i.e., Candiduria) is a common nosocomial infection accounting for 5–10 % of all positive urine cultures in hospitals and tertiary care facilities [6] . Despite Candida being the most prevalent fungi in patients suffering from UT infections, [2b, 7] there are no clinically‐approved tests for direct detection of Candiduria [8] …”

Rationales Design von Phe‐BODIPY‐Aminosäuren als fluorogene Bausteine für den peptidbasierten Nachweis von Candida‐Infektionen im Harntrakt

“…The presence of Candida species in urine (i.e., Candiduria) is a common nosocomial infection accounting for 5-10% of all positive urine cultures in hospitals and tertiary care facilities. [6] Despite Candida being the most prevalent fungi in patients suffering from UT infections, [2b, 7] there are no clinically-approved tests for direct detection of Candiduria. [8] Optical imaging is a powerful tool to investigate essential biological processes in cells.…”

“…Das Vorhanden-häufige nosokomiale Infektion, die 5-10 % aller positiven Urinkulturen in Krankenhäusern und tertiären Pflegeeinrichtungen ausmacht. [6] Obwohl Candida der am häufigsten vorkommende Pilz bei Patienten mit UT-Infektionen ist, [2b, 7] gibt es keine klinisch zugelassenen Tests für den direkten Nachweis von Candiduria. [8] Die optische Bildgebung ist ein leistungsfähiges Instrument zur Untersuchung wesentlicher biologischer Prozesse in Zellen.…”

“…In diesem Zusammenhang sind Urinproben aufgrund ihrer Zugänglichkeit und ihrer direkten Relevanz für Harnwegsinfektionen attraktiven klinischen Proben. Das Vorhandensein von Candida ‐Zellen im Urin (d.h. Candiduria) ist eine häufige nosokomiale Infektion, die 5–10 % aller positiven Urinkulturen in Krankenhäusern und tertiären Pflegeeinrichtungen ausmacht [6] . Obwohl Candida der am häufigsten vorkommende Pilz bei Patienten mit UT‐Infektionen ist, [2b, 7] gibt es keine klinisch zugelassenen Tests für den direkten Nachweis von Candiduria [8] …”