Rothia aeria and Rothia dentocariosa as biofilm builders in infective endocarditis

Greve, Dustin; Moter, Annette; Kleinschmidt, Malte; Pfäfflin, Frieder; Stegemann, Miriam; Kursawe, Laura; Grubitzsch, Herko; Falk, Volkmar; Kikhney, Judith

doi:10.1016/j.ijmm.2021.151478

Cited by 17 publications

(16 citation statements)

References 35 publications

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“…In addition, our study showed that the relative abundance of Firmicutes and Actinomycetes in the airway of PTB increased, while the relative abundance of other phyla in the airway of PTB decreased, which was similar to the report of Jing Wu [ 23 ] and P. Krishna [ 18 ]. As an opportunistic pathogen, Rothia could cause endocarditis, meningitis, and bacteremia in people with low immunity [ 24 ]. Atopobium was the causative agent of bacterial vaginitis, which could also cause bacteremia in people with low immunity [ 25 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

Airway microecology in rifampicin-resistant and rifampicin-sensitive pulmonary tuberculosis patients

et al. 2022

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Background Pulmonary tuberculosis is a chronic infectious disease of the respiratory system. It is still one of the leading causes of death from a single infectious disease, but it has been stuck in the study of a single pathogen. Recent studies have shown that many diseases are associated with disruption of the native microbiota. In this study we investigated the occurrence of tuberculosis and the correlation between drug resistance and respiratory flora. High-throughput 16 S rRNA gene sequencing was used to characterize the respiratory microbiota composition of 30 tuberculosis (TB) affected patients and compared with 30 healthy (H) controls. According to their Gene Xpert results, 30 pulmonary tuberculosis patients were divided into 12 persons in the drug-sensitive group (DS0) and 18 persons in the drug-resistant group (DR0). The microbial flora of the two were compared with the H group. Results The data generated by sequencing showed that Firmicutes, Proteus, Bacteroides, Actinomyces and Fusobacterium were the five main bacterial phyla detected, and they constituted more than 96% of the microbial community. The relative abundances of Fusobacterium, Haemophilus, Porphyromonas, Neisseria, TM7, Spirochetes, SR1, and Tenericutes in the TB group was lower than that of the H group, and Granulicatella was higher than the H group. The PcoA diagrams of the two groups had obvious clustering differences. The Alpha diversity of the TB group was lower than that of the H group, and the Beta diversity was higher than that of the H group (P < 0.05). The relative abundance of Streptococcus in the DS0 group was significantly higher than that in the DR0 group (P < 0.05). Conclusion Pulmonary tuberculosis can cause disorders of the respiratory tract microbial flora, in which the relative abundance of Streptococcus was significantly different between rifampicin-sensitive and rifampicin-resistant patients.

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Section: Discussionmentioning

confidence: 99%

Airway microecology in rifampicin-resistant and rifampicin-sensitive pulmonary tuberculosis patients

et al. 2022

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“…Regarding the cryptic microorganisms identified (Table S3) [15,16,[38][39][40][41][42][43][44], Staphylococcus spp. and Cutibacterium spp.…”

Section: Discussionmentioning

confidence: 99%

Cryptic Oral Microbiota: What is its Role as OSA-related Periodontal Pathogens?

Corral¹,

Daza²,

Jimenez³

et al. 2022

Preprint

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Commonly the periodontitis has been linked to periodontopathogens categorized in Socransky's microbial complexes, however, there is a lack of knowledge regarding “other microorganisms” or "cryptic microorganisms", which are rarely thought of as significant oral pathogens and are neither previously categorized nor connected to illnesses in the oral cavity. This study hypothesized that these cryptic microorganisms could contribute to the modulation of oral microbiota present in health or disease (periodontitis and/or OSA patients). For this purpose, the presence and the correlation among these cultivable cryptic oral microorganisms were identified and their possible role in both conditions was determined. Data from oral samples of individuals with or without periodontitis and with or without OSA were obtained from a previous study. Demographic data, clinical oral characteristics, and genera and species of cultivable cryptic oral microorganisms identified by MALDI-TOF were recorded. The data of 75 participants were analyzed to determine the relative frequencies of cultivable cryptic microorganisms’ genus and species, microbial clusters and correlations tests were performed. According to periodontal condition, Gingivitis - dental biofilm-induced in reduced periodontium and stage III periodontitis were found to have the highest diversity of cryptic microorganism species. Based on the experimental condition these findings showed that there are genera related to disease conditions and others related to healthy conditions, with species that could be related to different chronic diseases being highlighted as comorbidities periodontitis and OSA. The cryptic microorganisms within the oral microbiota of patients with periodontitis and OSA are present as potential pathogens, promoting the development of dysbiotic microbiota, and the occurrence of chronic diseases, which have been previously proposed to be common risk factors for periodontitis and OSA. Understanding the function of possible pathogens in the oral microbiota will take more research.

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“…promote infection and disease of the respiratory system (King, 2012;Deutschmann et al, 2013;Yuan et al, 2013;Noguchi et al, 2015;Li et al, 2022). The circulatory system is also affected by CL/P-prone microbes: R. dentocariosa biofilm formation in the heart can promote ineffective endocarditis (Greve et al, 2021), a condition that is also stimulated by S. mutans and A. aphrophilus (Nørskov-Lauritsen, 2014;Nomura et al, 2020); S. mutans has also been linked to the development of atherosclerotic plaque (Kesavalu et al, 2012). In addition, both P. gingivalis and S. gordonii can cause bone resorption (Kassem et al, 2015;Park et al, 2020), while Streptococcus spp.…”

Section: Streptococcus Salivariusmentioning

confidence: 99%

Characterizing the microbiota of cleft lip and palate patients: a comprehensive review

Gershater

Liu

Xue

et al. 2023

Front. Cell. Infect. Microbiol.

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Orofacial cleft disorders, including cleft lip and/or palate (CL/P), are one of the most frequently-occurring congenital disorders worldwide. The health issues of patients with CL/P encompass far more than just their anatomic anomaly, as patients with CL/P are prone to having a high incidence of infectious diseases. While it has been previously established that the oral microbiome of patients with CL/P differs from that of unaffected patients, the exact nature of this variance, including the relevant bacterial species, has not been fully elucidated; likewise, examination of anatomic locations besides the cleft site has been neglected. Here, we intended to provide a comprehensive review to highlight the significant microbiota differences between CL/P patients and healthy subjects in various anatomic locations, including the teeth inside and adjacent to the cleft, oral cavity, nasal cavity, pharynx, and ear, as well as bodily fluids, secretions, and excretions. A number of bacterial and fungal species that have been proven to be pathogenic were found to be prevalently and/or specifically detected in CL/P patients, which can benefit the development of CL/P-specific microbiota management strategies.

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Rothia aeria and Rothia dentocariosa as biofilm builders in infective endocarditis

Cited by 17 publications

References 35 publications

Airway microecology in rifampicin-resistant and rifampicin-sensitive pulmonary tuberculosis patients

Airway microecology in rifampicin-resistant and rifampicin-sensitive pulmonary tuberculosis patients

Cryptic Oral Microbiota: What is its Role as OSA-related Periodontal Pathogens?

Characterizing the microbiota of cleft lip and palate patients: a comprehensive review

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