Rotenone, Rhodamine 123 and Janus Green Induce Damage to Nuclear DNA in Ascites Tumor Cells from Mice, Rotenone and Rhodamine in X-Irradiated Cells Contribute to the Maintenance of Genome Integrity
E. A Kuznetsova,
N. P Sirota
Abstract:Rotenone, Rhodamine 123, and Janus green B, inhibitors of mitochondria function, are currently investigated to create pharmacological agents that induce mitochondrial dysfunction and apoptosis. Since impaired mitochondrial function is associated with overproduction of reactive oxygen species, it seems relevant to compare DNA damage induced by the said inhibitors in Ehrlich ascites carcinoma cells and murine lymphocytic leukemia P388 and DNA damage induced by the direct effect of ionizing radiation (X-rays) tha… Show more
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