2005
DOI: 10.1055/s-2005-864182
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Rotenoids and Isoflavones fromSarcolobus globosus

Abstract: Sarcolobus globosus is a medicinal plant growing in mangrove forests in Asia. No constituents from this plant have been reported previously. From the diethyl ether extract of S. globosus a new rotenoid sarcolobin and a new isoflavone sarcolobone, as well as the previously known rotenoids tephrosin, 12aalpha-hydroxydeguelin, 11-hydroxytephrosin, 12a-hydroxyrotenone, 12aalpha-hydroxyrotenone, 6aalpha,12aalpha-12a-hydroxyelliptone, 6a,12a-dehydrodeguelin, 13- homo-13-oxa-6a,12a-dehydrodeguelin, the isoflavone bar… Show more

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Cited by 23 publications
(19 citation statements)
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“…It can reduce the risk of breast and prostate cancers [3,4], inhibit the growth and metastasis of cancer cells in vitro and in vivo [5] and enhance the sensitivity of cancer cells to chemotherapy and radiotherapy [6,7]. Barbigerone (Figure 1), a naturally occurring isoflavone, was first found from the seeds of Tephrosia barbigera in 1979 [8] and could be found from other plants [9][10][11][12][13]. Barbigerone has exhibited profound pharmacological properties, such as antioxidant and 15-lipoxygenase inhibitory activity [12], and antiplasmodial activity [13].…”
Section: Introductionmentioning
confidence: 99%
“…It can reduce the risk of breast and prostate cancers [3,4], inhibit the growth and metastasis of cancer cells in vitro and in vivo [5] and enhance the sensitivity of cancer cells to chemotherapy and radiotherapy [6,7]. Barbigerone (Figure 1), a naturally occurring isoflavone, was first found from the seeds of Tephrosia barbigera in 1979 [8] and could be found from other plants [9][10][11][12][13]. Barbigerone has exhibited profound pharmacological properties, such as antioxidant and 15-lipoxygenase inhibitory activity [12], and antiplasmodial activity [13].…”
Section: Introductionmentioning
confidence: 99%
“…C-1a (d 138.1), C-2 (146.7), C-3 (145.2) and C-4a (143.9). Such oxygenation pattern has been observed in the modified rotenoids 13-homo-13-oxa-6a,12a-dehydrorotenone (5) and 13-homo-13-oxa-6a,12a-dehydrodeguelin (6) (Fang and Casida, 1997;Wangenesteen et al, 2005). As in these compounds, ring B in 2 is also seven-membered with a second oxygen atom (O-13) bridging C-1a and C-12a.…”
Section: Resultsmentioning
confidence: 87%
“…This is only the second report on the natural occurrence of this compound, having recently been reported from Sarcolobus globosus (Asclepiadaceae) (Wangenesteen et al, 2005). It appears that 7 is formed in this plant through oxidative cleavage of the C12-C12a bond in the 12a-hydroxyrotenoloid, 1.…”
Section: Resultsmentioning
confidence: 91%
“…Barbigerone ( Figure 1A), a naturally occurring isoflavone, formally named as 2 ', 4', 5'-trimethoxy-6'', 6''-dimethylpyrano (2'', 3'': 7, 8) isoflavone, was first isolated from the seeds of Tephrosia barbigera in 1979 (Vilain, 1980) and found with minor content in species of Milletia of Leguminosae family and species of Satcolobus of Asclepiadaceae family (Yenesew et al, 1998;Wangensteen et al, 2005). This compound has exhibited profound pharmacological properties, such as antioxidant, 15-lipoxygenase inhibitory activity (Wangensteen et al, 2006), and anti-plasmodial activity (Yenesew et al, 2003).…”
Section: Barbigerone Inhibits Tumor Angiogenesis Growth and Metastasmentioning
confidence: 99%