Rotaviruses and Noroviruses as Etiological Agents of Acute Intestinal Diseases of Ukrainian Children

Soloviov, S. O.; Todosiichuk, Tetiana S.; Kovaliuk, Olena V.; Filippelli, Gabriel M.; Трохименко, О. П.; Dziublyk, Iryna V.; Rodd, Zachary A.

doi:10.3390/ijerph19084660

Cited by 2 publications

(4 citation statements)

References 27 publications

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“…21,22 In both Poland and Ukraine, RV gastroenteritis prevalence peaks in winter months. 20,21 RV gastroenteritis is characterized by 3 basic symptoms: fever, vomiting and diarrhea, which were also common in our patients. 20 Importantly, children in our series presented with a particularly severe course of gastroenteritis, with prolonged lethargy despite appropriate treatment.…”

Section: Epidemiologic Circumstancesmentioning

confidence: 57%

“…RV gastroenteritis is characterized by 3 basic symptoms: fever, vomiting and diarrhea, which were also common in our patients. 20 Importantly, children in our series presented with a particularly severe course of gastroenteritis, with prolonged lethargy despite appropriate treatment. This is in line with European studies, which showed that RV gastroenteritis is more severe than gastroenteritis caused by other viruses.…”

Section: Discussionmentioning

confidence: 77%

“…18,19 RV was one of the 2 most common agents responsible for acute diarrhea in Ukrainian children in years 2016–2020. 8,20 Similarly, RV is a leading cause of gastroenteritis in Polish children, with most hospitalized patients being younger than 5 years old. 21,22 In both Poland and Ukraine, RV gastroenteritis prevalence peaks in winter months.…”

Section: Discussionmentioning

confidence: 99%

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Ukrainian War Refugee Children With Particularly Severe Viral Infections: A Case Series Report

Pluta,

Karny,

Lipińska

et al. 2023

Pediatric Infectious Disease Journal

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The humanitarian crisis in Ukraine in 2022 led to a massive migration of refugees to Poland. Immigrant children, living in overcrowded humanitarian hubs, were exposed to multiple stressful factors likely affecting their immune systems. This case series study aimed to describe a particularly severe course of common viral infections, in Ukrainian refugee children. We present 2 case series of Ukrainian refugee children: 5 hospitalized due to either adenovirus (AdV) and 8 with rotavirus (RV) infection, admitted within 3 months in each case series, recruited retrospectively. Most patients lived in humanitarian hubs and were neglected on admission (dehydrated, with poor hygiene and anxious). All RV infection cases had symptoms of severe gastroenteritis requiring intravenous rehydration. Metabolic acidosis was present in 6 children, and hypoglycemia in 4 participants. None of them were vaccinated against RV. All children with AdV infection had prolonged fever, dyspnea requiring oxygen therapy and hyperinflammation. In 2 AdV infection cases with no clinical improvement and increasing inflammatory markers, intravenous immunoglobulins and glucocorticosteroids were used. The combination of stressful factors and living in overcrowded hubs during the high prevalence of viral infections led to a particularly severe course of viral infections in Ukrainian refugee children.

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Section: Epidemiologic Circumstancesmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Ukrainian War Refugee Children With Particularly Severe Viral Infections: A Case Series Report

Pluta,

Karny,

Lipińska

et al. 2023

Pediatric Infectious Disease Journal

View full text Add to dashboard Cite

show abstract

“…Не менш важливою проблемою залишаються інфекції шлунково-кишкового тракту, зокрема вірусні гастроентерити, етіологічними агентами яких є ротавіруси, норовіруси, кишкові аденовіруси, астровіруси. Вірусні гастроентерити особливо вражають дітей до п'яти років [4]. Наразі відсутні препарати етіотропної дії, які можуть бути ефективними для лікування вірусних гастроентеритів, тому актуальною залишається комбінована симптоматична та патогенетична те-рапія як для дітей, так і для дорослих [5,6].…”

Section: вступunclassified

In vitro Modeling of the Effect of Lactobacillus Metabolites on the Systemic Response of the Body in Intestinal Viral Infection

Soloviov,

Trokhimenko,

Polishchuk

et al. 2024

Innov Biosyst Bioeng

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Background. Viral infectious diseases remain a significant cause of morbidity and mortality worldwide. The lack of effective antiviral drugs for the treatment of viral gastroenteritis emphasizes the relevance of various forms of combination therapy, including a balanced diet and the use of probiotics. Objective. To verify in vitro the hypothesis about the effect of metabolites from probiotic strains of lactobacilli on the systemic response of the body in intestinal viral infection. Methods. The objects of study were filtrates of culture fluids from probiotic lactobacillus strains L. delbrueckii subsp. lactis LE and L. rhamnosus LB3. HEp-2 and Namalwa cell cultures and vesicular stomatitis test virus were used as biological test objects. The study employed spectrophotometric and cytofluorometric analysis. Results. The absence of a direct anti-inflammatory effect in the samples of lactobacillus culture fluid filtrates was revealed. It was found that the culture fluid filtrate of the lactobacillus strain L. delbrueckii subsp. lactis LE exhibited the most pronounced properties of an interferon coinducer. The proliferative index (PI) of HEp-2 cells was analyzed under different effects. Cells incubated with lactobacillus culture fluid filtrate (LE) showed an increase in PI for young cells, a decrease for mid-mature cells, and an increase for late-mature cells. The combined effect of TNF-a and lactobacillus LE culture filtrate was characterized by stimulation of PI for medium-mature cells and significant inhibition of PI of late-mature cells. Conclusions. The synergistic effect of lactobacillus culture filtrates and inflammatory factors will contribute to the accelerated elimination of late-mature and affected cells from the intestine and stimulate the proliferation of young and medium-mature cells to replace them, thereby promoting the regeneration of the intestinal epithelium and accelerate recovery. At the same time, probiotic strains of lactobacilli can enhance the interferonogenic properties of gastroenteritis viruses, and ultimately stimulating the formation of specific immunity in these diseases.

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Rotaviruses and Noroviruses as Etiological Agents of Acute Intestinal Diseases of Ukrainian Children

Cited by 2 publications

References 27 publications

Ukrainian War Refugee Children With Particularly Severe Viral Infections: A Case Series Report

Ukrainian War Refugee Children With Particularly Severe Viral Infections: A Case Series Report

In vitro Modeling of the Effect of Lactobacillus Metabolites on the Systemic Response of the Body in Intestinal Viral Infection

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