Rotavirus vaccines: Opportunities and challenges

Grimwood, Keith; Lambert, Stephen B.

doi:10.4161/hv.5.2.6924

Cited by 63 publications

(46 citation statements)

References 111 publications

(212 reference statements)

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“…27 Vomiting is a recognisable barrier to the effective use of ORT, and this is because some caregivers are unaware of the need to continue giving ORT and other feeds to their child after the vomiting has subsided. 33 In some cases, this practice is attributable to the caregivers' level of education, and the quality of diarrhoea-related health messages that they receive. 34,35 Several studies have been conducted on this subject in our context.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the use of oral rehydration therapy in the management of diarrhoea among children under 5: knowledge attitudes and practices of mothers/caregivers

Onwukwe

Deventer

Omole

2015

South African Family Practice

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Introduction:Dehydration from diarrhoea and vomiting has remained a threat to the lives of children under 5 years old especially in developing countries. Oral rehydration therapy (ORT) administered by caregivers is lifesaving but evidence shows unsatisfactory implementation of this. Methods: A descriptive cross-sectional study involving 377 systematically recruited caregivers was conducted. A face to face questionnaire was used to measure the level of ORT knowledge, attitudes, practices, and responses to diarrhoea and vomiting in children. The data collected were analysed by the use of descriptive statistics, the chi-square test, and Fisher's exact test. The main outcome measures were the level of ORT knowledge of mothers/caregivers, attitudes, practices, and responses to diarrhoea. Results: In total, 88.3% of caregivers were biological mothers. Only 53.3% were aware of the importance of initiating ORT at home with the onset of diarrhoea, and 4% administered traditional remedies. Some 66% of the caregivers had used ORT, 18.3% knew that it prevents dehydration, and 33.7% were able to prepare a correct recipe. Knowledge and attitudes correlated with the ability to initiate ORT at home (p = 0.0000). Conclusion: Unsatisfactory uptake of ORT appears to be due to caregivers' lack of knowledge concerning the perfect mixture, function, and appropriate quantity of ORT administration. Mothers have heard of ORT, but some still believe that traditional remedies are better in treating diarrhoea.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the use of oral rehydration therapy in the management of diarrhoea among children under 5: knowledge attitudes and practices of mothers/caregivers

Onwukwe

Deventer

Omole

2015

South African Family Practice

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“…2 The most common genotypes of rotavirus detected around the world include the G types G1, G2, G3, G4, and G9, in association with the P types P [8], P [6], and P [4]. 3 However, many recent studies have described the detection of uncommon or untypable genotypes in developing countries. 4 Two live attenuated vaccines have been licensed and proven efficacious for protection against rotavirus infections, namely RotaTeq (Merck & Co., Whitehouse Station, NJ) and Rotarix (GlaxoSmithKline Biologicals, Rixensart, Belgium).…”

mentioning

confidence: 99%

Surveillance and Molecular Characterization of Group A Rotaviruses in Goroka, Papua New Guinea

Horwood

Luang-Suarkia²,

Bebes³

et al. 2012

The American Journal of Tropical Medicine and Hygiene

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Abstract. In this study, we investigated the molecular epidemiology of group A rotaviruses in cases of acute gastroenteritis in Goroka, Papua New Guinea. From April 2008 through November 2010, 813 diarrheal stool samples were collected from children 5 years of age hospitalized with acute gastroenteritis. Rotavirus antigen was detected in 31.2% of samples using a commercial enzyme-linked immunosorbent assay. Genotyping revealed the presence of the globally circulating strains G1P[8] (50.0%), G3P[8] (23.0%), and G2P[4] (8.2%). The globally emerging strains G9 and G12 were detected in 1.2% and 6.1% of samples, respectively. Mixed infections were detected in a high proportion of samples (11.9%), with 9.0% and 3.7% of samples displaying multiple G and P genotypes, respectively.

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“…Vomiting is a recognisable barrier to the effective use of ORT, as shown in other studies, mainly because caregivers are unaware of the need to continue ORT after the vomiting has subsided. 19 Although use of ORT does not reduce the incidence of diarrhoea, more than 90% of dehydration from diarrhoea can be prevented with its use, leading WHO to make it the mainstay of diarrhoea management. 20 In recognition of the fact that successful management of diarrhoea lies in the hands of well-informed caregivers rather than the health care system, the way forward is to support and inform caregivers about ORT so that they are more inclined to use it.…”

Section: 18mentioning

confidence: 99%

Perceptions and practices of oral rehydration therapy among caregivers in Cork, Ireland

Maduemem

Rizwan

Akubue

et al. 2017

Int J Community Med Public Health

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Background: The use of oral rehydration therapy (ORT) remains limited despite international guidelines for diarrhoeal disease management. This study was done to assess the perception and practice of ORT among caregivers in the management of diarrhoeal disease. Methods: A descriptive cross-sectional study was conducted in the Paediatric Department of Cork University Hospital, Ireland. The study population consisted of parents/guardians of children attending the Paediatric Day Ward or Paediatric Outpatient Department. A questionnaire consisting of 30 questions was originally designed by the first author to include all the study variables, and was given to the participants. Results: Out of 402 respondents, 76.6% (n=308) could describe diarrhoea correctly and perceived it as a serious illness. 81.3% (n=327) of participants knew about ORT but only 27.2% (n=89) agreed it was an ideal first line of management of diarrhoeal disease. Diarrhoeal episodes in the preceding 12 months were reported predominantly in children under the age of 5 years (p<0.001). Only 8.7% (n=17) of caregivers used ORT for diarrhoeal management. Conclusions: Poor uptake of ORT appears to be due to caregivers’ negative perceptions of ORT. This emphasizes the need for correct and adequate education.

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Rotavirus vaccines: Opportunities and challenges

Cited by 63 publications

References 111 publications

Evaluation of the use of oral rehydration therapy in the management of diarrhoea among children under 5: knowledge attitudes and practices of mothers/caregivers

Evaluation of the use of oral rehydration therapy in the management of diarrhoea among children under 5: knowledge attitudes and practices of mothers/caregivers

Surveillance and Molecular Characterization of Group A Rotaviruses in Goroka, Papua New Guinea

Perceptions and practices of oral rehydration therapy among caregivers in Cork, Ireland

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