Rotavirus Vaccine Take in Infants Is Associated With Secretor Status

Armah, George; Cortese, Margaret M.; Dennis, Francis E; Yu, Ying; Morrow, Ardythe L.; McNeal, Monica; Lewis, Kristen; Awuni, Denis; Armachie, Joseph; Parashar, Umesh D.

doi:10.1093/infdis/jiy573

Cited by 36 publications

(29 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies from Nicaragua [27,53], Pakistan [54], Ghana [55], and Malawi [15] have tested this hypothesis by measuring IgA seroconversion and/or vaccine strain shedding in association to HBGAs (Table 3). Five studies investigated Rotarix whereas one study investigated the RotaTeq vaccine.…”

Section: Rotavirus Vaccine Take Is Associated With Hbgasmentioning

confidence: 99%

The Impact of Human Genetic Polymorphisms on Rotavirus Susceptibility, Epidemiology, and Vaccine Take

Sharma

Hagbom

Svensson

et al. 2020

Viruses

View full text Add to dashboard Cite

Innate resistance to viral infections can be attributed to mutations in genes involved in the immune response, or to the receptor/ligand. A remarkable example of the latter is the recently described Mendelian trait resistance to clinically important and globally predominating genotypes of rotavirus, the most common agent of severe dehydrating gastroenteritis in children worldwide. This resistance appears to be rotavirus genotype-dependent and is mainly mediated by histo-blood group antigens (HBGAs), which function as a receptor or attachment factors on gut epithelial surfaces. HBGA synthesis is mediated by fucosyltransferases and glycosyltransferases under the genetic control of the FUT2 (secretor), FUT3 (Lewis), and ABO (H) genes on chromosome 19. Significant genotypic and phenotypic diversity of HBGA expression exists between different human populations. This genetic diversity has an effect on genotype-specific susceptibility, molecular epidemiology, and vaccine take. Here, we will discuss studies on genetic susceptibility to rotavirus infection and place them in the context of population susceptibility, rotavirus epidemiology, vaccine take, and public health impact.

show abstract

Section: Rotavirus Vaccine Take Is Associated With Hbgasmentioning

confidence: 99%

The Impact of Human Genetic Polymorphisms on Rotavirus Susceptibility, Epidemiology, and Vaccine Take

Sharma

Hagbom

Svensson

et al. 2020

Viruses

View full text Add to dashboard Cite

show abstract

“…Histo-blood group antigens has been shown to affect susceptibility to rotavirus infection in a P-type dependent manner, with P [8] mainly infecting Lewis and secretor positive children and P [6] infecting mainly Lewis negative children [11]. Studies have shown a lower vaccine take for non-secretors [39,40] and it is thus possible that vaccinated Lewis and secretor negative children can be subsequently symptomatically infected with P[6] rotaviruses, common in sub-Saharan Africa [11].…”

Section: Epidemiology and Infectionmentioning

confidence: 99%

Norovirus and rotavirus in children hospitalised with diarrhoea after rotavirus vaccine introduction in Burkina Faso

et al. 2020

View full text Add to dashboard Cite

Several studies report norovirus as the new leading cause of severe gastroenteritis in children after the global introduction of rotavirus vaccines. Burkina Faso introduced general rotavirus vaccination with the oral pentavalent vaccine RotaTeq in November 2013 and quickly reached a vaccine coverage of >90%. This study describes detection rates, clinical profiles and the molecular epidemiology of norovirus and rotavirus infections in 146 children aged <5 years with severe acute gastroenteritis in Ouagadougou, consecutively enrolled from a hospital between January 2015 and December 2015. Virus detection was performed with an antigen test or real-time polymerase chain reaction (PCR) and genotyping was performed by nucleotide sequencing or multiplex PCR. Rotavirus was found in 14% and norovirus in 20% of faecal samples. Norovirus infection was significantly more associated with severe dehydration compared to rotavirus (P < 0.001). Among genotyped norovirus samples 48% (12/25) belonged to GII.4 which caused significantly more diarrhoeal episodes than non-GII.4 genotypes (P = 0.01). The most common rotavirus genotypes were G2P[4] (30%), G12P[6] (25%) and G12P[8] (20%). Fifty percent of the rotavirus positive children were infected with fully or partly heterotypic strains. In conclusion, this study found a higher proportion of norovirus causing more severe symptoms in children with diarrhoea in Burkina Faso after the introduction of rotavirus vaccination.

show abstract

“…Studies have shown that this interaction is P genotype- specific, similar to that observed for VP1 of human noroviruses, and that the susceptibility or resistance to both viruses is largely dependent on the presence or absence of HBGA on gut epithelial surfaces. In addition, the association between the secretor status and infection, initially demonstrated for noroviruses, has also been shown by recent studies for rotavirus, which has demonstrated a correlation between infection and the presence of a functional FUT2 phenotype [ 23 , 42 , 43 , 44 ].…”

Section: Discussionmentioning

confidence: 79%

FUT2, Secretor Status and FUT3 Polymorphisms of Children with Acute Diarrhea Infected with Rotavirus and Norovirus in Brazil

Tonini

Barreira

Santolin

et al. 2020

Viruses

View full text Add to dashboard Cite

Host susceptibility according to human histo-blood group antigens (HBGAs) is widely known for norovirus infection, but is less described for rotavirus. Due to the variable HBGA polymorphism among populations, we aimed to evaluate the association between HBGA phenotypes (ABH, Lewis and secretor status) and susceptibility to rotavirus and norovirus symptomatic infection, and the polymorphisms of FUT2 and FUT3, of children from southeastern Brazil. Paired fecal-buccal specimens from 272 children with acute diarrhea were used to determine rotavirus/norovirus genotypes and HBGAs phenotypes/genotypes, respectively. Altogether, 100 (36.8%) children were infected with rotavirus and norovirus. The rotavirus P[8] genotype predominates (85.7%). Most of the noroviruses (93.8%) belonged to genogroup II (GII). GII.4 Sydney represented 76% (35/46) amongst five other genotypes. Rotavirus and noroviruses infected predominantly children with secretor status (97% and 98.5%, respectively). However, fewer rotavirus-infected children were Lewis-negative (8.6%) than the norovirus-infected ones (18.5%). FUT3 single nucleotide polymorphisms (SNP) occurred mostly at the T59G > G508A > T202C > C314T positions. Our results reinforce the current knowledge that secretors are more susceptible to infection by both rotavirus and norovirus than non-secretors. The high rate for Lewis negative (17.1%) and the combination of SNPs, beyond the secretor status, may reflect the highly mixed population in Brazil.

show abstract

Rotavirus Vaccine Take in Infants Is Associated With Secretor Status

Cited by 36 publications

References 15 publications

The Impact of Human Genetic Polymorphisms on Rotavirus Susceptibility, Epidemiology, and Vaccine Take

The Impact of Human Genetic Polymorphisms on Rotavirus Susceptibility, Epidemiology, and Vaccine Take

Norovirus and rotavirus in children hospitalised with diarrhoea after rotavirus vaccine introduction in Burkina Faso

FUT2, Secretor Status and FUT3 Polymorphisms of Children with Acute Diarrhea Infected with Rotavirus and Norovirus in Brazil

Contact Info

Product

Resources

About