Rotavirus Strain Trends During the Postlicensure Vaccine Era: United States, 2008–2013

Bowen, Michael D.; Mijatovic-Rustempasic, Slavica; Esona, Mathew D.; Teel, Elizabeth N.; Gautam, Rashi; Sturgeon, Michele; Azimi, Parvin H.; Baker, Carol J.; Bernstein, David I.; Boom, Julie A.; Chappell, James D.; Donauer, Stephanie; Edwards, Kathryn M.; Englund, Janet A.; Halasa, Natasha; Harrison, Christopher J.; Johnston, Samantha; Klein, Eileen J.; McNeal, Monica; Moffatt, Mary; Rench, Marcia A.; Sahni, Leila C; Selvarangan, Rangaraj; Staat, Mary Allen; Szilâgyi, Peter G.; Weinberg, Geoffrey A.; Wikswo, Mary E.; Parashar, Umesh D.; Payne, Daniel C.

doi:10.1093/infdis/jiw233

Cited by 58 publications

(87 citation statements)

References 41 publications

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“…One such example is the New Vaccine Surveillance Network, which monitors the etiology of acute gastroenteritis in the United States and has documented the decline in Group A rotavirus-associated gastroenteritis incidence among children following reinitiation of rotavirus immunization in the country (11). The Network continues to monitor the genotypic variation in the rotavirus strains circulating in the United States and has noted a major shift in the predominant genotype prevalence in the years 2008-2013.…”

Section: The Expanding Use Of Surveillance Systemsmentioning

confidence: 99%

Public Health Surveillance Systems: Recent Advances in Their Use and Evaluation

Groseclose

Buckeridge

2017

Annu. Rev. Public Health

220

179

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Surveillance is critical for improving population health. Public health surveillance systems generate information that drives action, and the data must be of sufficient quality and with a resolution and timeliness that matches objectives. In the context of scientific advances in public health surveillance, changing health care and public health environments, and rapidly evolving technologies, the aim of this article is to review public health surveillance systems. We consider their current use to increase the efficiency and effectiveness of the public health system, the role of system stakeholders, the analysis and interpretation of surveillance data, approaches to system monitoring and evaluation, and opportunities for future advances in terms of increased scientific rigor, outcomes-focused research, and health informatics.

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Section: The Expanding Use Of Surveillance Systemsmentioning

confidence: 99%

Public Health Surveillance Systems: Recent Advances in Their Use and Evaluation

Groseclose

Buckeridge

2017

Annu. Rev. Public Health

220

179

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“…RVs are genetically diverse, containing five genogroups (P[I]-P[V]) with 40 known genotypes (P[1]-P [40]) among group A RVs based on the VP4 sequences [7][8][9]. These RVs can infect humans and/or different animal species, among which P [8], P [4], and P [6] RVs in P[II] genogroup are the predominant genotypes causing diseases in humans worldwide [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Molecular basis of P[6] and P[8] major human rotavirus VP8* domain interactions with histo-blood group antigens

Yang

Tan

et al. 2019

Preprint

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Initial cell attachment of rotavirus (RV) to specific cell surface glycans, which is the essential first step in RV infection, is mediated by the VP8* domain of the spike protein VP4. Recently, human histo-blood group antigens (HBGAs) have been identified as ligands or receptors for human RV strains. RV strains in the P[4] and P[8] genotypes of the P[II] genogroup share common recognition of the Lewis b and H type 1 antigens, while P[6], which is one of the other genotypes in P[II], only recognizes the H type 1 antigen. The molecular basis of receptor recognition by the major human P[8] RVs remains unknown due to lack of experimental structural information. Here, we used nuclear magnetic resonance (NMR) titration experiments and NMRderived high ambiguity driven docking (HADDOCK) methods to elucidate the molecular basis for P[8] VP8* recognition of the Le b and type 1 HBGAs and for P[6] recognition of H type 1 HBGAs. Unlike P[6] VP8* that recognizes H type 1 HGBAs in a binding surface composed of an α-helix and a β-sheet, referred as "βα binding domain", the P[8] VP8* binds the type 1 HBGAs requiring the presence of the Lewis epitope in a previously undescribed pocket formed by two β-sheets, referred as "β binding domain". The observation that P[6] and P[8] VP8* domains recognize different glycan structures at distinct binding sites supports the hypothesis that RV evolution is driven, at least in part, by selective pressure driven adaptation to HBGA structural diversity of their natural hosts living in the world. Recognition of the role that HBGAs play in driving RV evolution is essential to understanding RV diversity, host ranges, disease burden and zoonosis and to developing strategies to improve vaccines against RV infections.

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“…gained global epidemiologic relevance, including in the United States (30)(31)(32). The impact of vaccine pressure on rotavirus evolution and selection remains unclear.…”

mentioning

confidence: 99%

“…Since then, these strains have been detected across the globe with increasing frequency, primarily as G12P [6] and G12P [8] combinations (29,31,35). In the United States, G12P [8] has been the predominant rotavirus type detected for the past several years (30). Human G12 VP7 segments cluster in three phylogenetic lineages, with the vast majority clustering in lineage III (31).…”

mentioning

confidence: 99%

Multiple Introductions and Antigenic Mismatch with Vaccines May Contribute to Increased Predominance of G12P[8] Rotaviruses in the United States

Ogden

Tan

Akopov

et al. 2019

J Virol

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Rotavirus is the leading global cause of diarrheal mortality for unvaccinated children under 5 years of age. The outer capsid of rotavirus virions consists of VP7 and VP4 proteins, which determine viral G and P types, respectively, and are primary targets of neutralizing antibodies. Successful vaccination depends upon generating broadly protective immune responses following exposure to rotaviruses presenting a limited number of G- and P-type antigens. Vaccine introduction resulted in decreased rotavirus disease burden but also coincided with the emergence of uncommon G and P genotypes, including G12. To gain insight into the recent predominance of G12P[8] rotaviruses in the United States, we evaluated 142 complete rotavirus genome sequences and metadata from 151 clinical specimens collected in Nashville, TN, from 2011 to 2013 through the New Vaccine Surveillance Network. Circulating G12P[8] strains were found to share many segments with other locally circulating strains but to have distinct constellations. Phylogenetic analyses of G12 sequences and their geographic sources provided evidence for multiple separate introductions of G12 segments into Nashville, TN. Antigenic epitopes of VP7 proteins of G12P[8] strains circulating in Nashville, TN, differ markedly from those of vaccine strains. Fully vaccinated children were found to be infected with G12P[8] strains more frequently than with other rotavirus genotypes. Multiple introductions and significant antigenic mismatch may in part explain the recent predominance of G12P[8] strains in the United States and emphasize the need for continued monitoring of rotavirus vaccine efficacy against emerging rotavirus genotypes. IMPORTANCE Rotavirus is an important cause of childhood diarrheal disease worldwide. Two immunodominant proteins of rotavirus, VP7 and VP4, determine G and P genotypes, respectively. Recently, G12P[8] rotaviruses have become increasingly predominant. By analyzing rotavirus genome sequences from stool specimens obtained in Nashville, TN, from 2011 to 2013 and globally circulating rotaviruses, we found evidence of multiple introductions of G12 genes into the area. Based on sequence polymorphisms, VP7 proteins of these viruses are predicted to present themselves to the immune system very differently than those of vaccine strains. Many of the sick children with G12P[8] rotavirus in their diarrheal stools also were fully vaccinated. Our findings emphasize the need for continued monitoring of circulating rotaviruses and the effectiveness of the vaccines against strains with emerging G and P genotypes.

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Rotavirus Strain Trends During the Postlicensure Vaccine Era: United States, 2008–2013

Cited by 58 publications

References 41 publications

Public Health Surveillance Systems: Recent Advances in Their Use and Evaluation

Public Health Surveillance Systems: Recent Advances in Their Use and Evaluation

Molecular basis of P[6] and P[8] major human rotavirus VP8* domain interactions with histo-blood group antigens

Multiple Introductions and Antigenic Mismatch with Vaccines May Contribute to Increased Predominance of G12P[8] Rotaviruses in the United States

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