Rotavirus replication and the role of cellular lipid droplets: New therapeutic targets?

Lever, Andrew; Desselberger, Ulrich

doi:10.1016/j.jfma.2016.02.004

Cited by 12 publications

(14 citation statements)

References 51 publications

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“…Rotaviruses are double-stranded RNA viruses and a leading cause of diarrhea in children. They replicate using cytoplasmic inclusion bodies named viroplasms [144]. Viroplasms often colocalize with LDs, and a close physical contact between NSP5, a non-structural viral protein, and the LD protein Perilipin A was demonstrated by fluorescent resonance energy transfer and cofractionation [145].…”

Section: 1 Protein Maturationmentioning

confidence: 99%

Lipid droplet functions beyond energy storage

Welte

Gould

2017

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

441

358

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Lipid droplets are cytoplasmic organelles that store neutral lipids and are critically important for energy metabolism. Their function in energy storage is firmly established and increasingly well characterized. However, emerging evidence indicates that lipid droplets also play important and diverse roles in the cellular handling of lipids and proteins that may not be directly related to energy homeostasis. Lipid handling roles of droplets include the storage of hydrophobic vitamin and signaling precursors, and the management of endoplasmic reticulum and oxidative stress. Roles of lipid droplets in protein handling encompass functions in the maturation, storage, and turnover of cellular and viral polypeptides. Other potential roles of lipid droplets may be connected with their intracellular motility and, in some cases, their nuclear localization. This diversity highlights that lipid droplets are very adaptable organelles, performing different functions in different biological contexts.

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Section: 1 Protein Maturationmentioning

confidence: 99%

Lipid droplet functions beyond energy storage

Welte

Gould

2017

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

441

358

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Section: Rotavirus Therapeutics and Immunoprophylaxismentioning

confidence: 99%

“…Rotavirus replication is intricately linked to host cell lipid metabolic pathways [ 169 ]. Increased levels of triglycerides have been observed in host cells following rotavirus infection [ 169 , 170 ]. Bile acids and Farnesoid X Receptor (FXR) agonists were shown to downregulate this process of lipid metabolism, thereby suppressing rotavirus replication in vivo and in vitro , and reduced viral shedding in mice [ 170 ].…”

Section: Rotavirus Therapeutics and Immunoprophylaxismentioning

confidence: 99%

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Therapeutics and Immunoprophylaxis Against Noroviruses and Rotaviruses: The Past, Present, and Future

Ghosh

Malik

Kobayashi

2018

CDM

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Background: Noroviruses and rotaviruses are important viral etiologies of severe gastroenteritis. Noroviruses are the primary cause of nonbacterial diarrheal outbreaks in humans, whilst rotaviruses are a major cause of childhood diarrhea. Although both enteric pathogens substantially impact human health and economies, there are no approved drugs against noroviruses and rotaviruses so far. On the other hand, whilst the currently licensed rotavirus vaccines have been successfully implemented in over 100 countries, the most advanced norovirus vaccine has recently completed phase-I and II trials.Methods: We performed a structured search of bibliographic databases for peer-reviewed research litera-ture on advances in the fields of norovirus and rotavirus therapeutics and immunoprophylaxis.Results: Technological advances coupled with a proper understanding of viral morphology and replication over the past decade has facilitated pioneering research on therapeutics and immunoprophylaxis against noroviruses and rotaviruses, with promising outcomes in human clinical trials of some of the drugs and vaccines. This review focuses on the various developments in the fields of norovirus and rotavirus thera-peutics and immunoprophylaxis, such as potential antiviral drug molecules, passive immunotherapies (oral human immunoglobulins, egg yolk and bovine colostral antibodies, llama-derived nanobodies, and anti-bodies expressed in probiotics, plants, rice grains and insect larvae), immune system modulators, probiot-ics, phytochemicals and other biological substances such as bovine milk proteins, therapeutic nanoparti-cles, hydrogels and viscogens, conventional viral vaccines (live and inactivated whole virus vaccines), and genetically engineered viral vaccines (reassortant viral particles, virus-like particles (VLPs) and other sub-unit recombinant vaccines including multi-valent viral vaccines, edible plant vaccines, and encapsulated viral particles).Conclusions: This review provides important insights into the various approaches to therapeutics and im-munoprophylaxis against noroviruses and rotaviruses..

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“…Dies geschieht anhand der Sequenzen der viralen Proteine VP4 und VP7, durch die für jeden Rotavirus-Genotyp ein G-(VP4-Sequenz) und ein P-Typ definiert werden. Rotaviren der Spezies A, die weltweit für humane Infektionen am wichtigsten ist, umfassen Genotypen aus einer Kombination von mindestens 27 G-Typen und mindestens 37 P-Typen [11].…”

Section: Biologie Von Rotavirenunclassified

Das Who is Who der Gastroenteritisviren

Kleines¹

2018

Krankenh.hyg. up2date

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Rotavirus replication and the role of cellular lipid droplets: New therapeutic targets?

Cited by 12 publications

References 51 publications

Lipid droplet functions beyond energy storage

Lipid droplet functions beyond energy storage

Therapeutics and Immunoprophylaxis Against Noroviruses and Rotaviruses: The Past, Present, and Future

Das Who is Who der Gastroenteritisviren

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