Rotavirus infections in calves: efficacy of oral vaccination in endemically infected herds

Leeuw, Peter W. de; Ellens, D. J.; Talmon, F P; Zimmer, G.; R, Kommerij

doi:10.1016/s0034-5288(18)32654-7

Cited by 38 publications

(27 citation statements)

References 5 publications

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“…In our investigations significant increases were not found either, although remarkable protective effects were shown by clinical and virological parameters [42]. Attempts to immunize calves actively by the oral route were unsuccessful under field conditions because of interference with maternally-derived antibodies [43,42].…”

Section: Bovine Coronavirus (Bcv)contrasting

confidence: 60%

Coronaviridae, pathogenetic and clinical aspects: An update

Möstl¹

1990

Comparative Immunology, Microbiology and Infectious Diseases

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Section: Bovine Coronavirus (Bcv)contrasting

confidence: 60%

Coronaviridae, pathogenetic and clinical aspects: An update

Möstl¹

1990

Comparative Immunology, Microbiology and Infectious Diseases

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“…In the field, nearly all adult cattle possess rotavirus antibodies and can transfer these via colostrum and milk to their offspring. Evidence has been presented that effective oral vaccination of calves against rotavirus-induced diarrhoea is hindered by the presence of these lacteal antibodies , 1980b;BOrki et al, 1983;De Leeuw and Tiessink, 1984). Our results with group C and D calves (Figs.…”

Section: Discussionsupporting

confidence: 45%

Intestinal antibody response after vaccination and infection with rotavirus of calves fed colostrum with or without rotavirus antibody

Zaane¹,

Ijzerman²,

Leeuw³

1986

Veterinary Immunology and Immunopathology

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The intestinal and systemic antibody response of calves vaccinated and/or challenged with rotavirus was studied employing isotype-specific ELISAs for the detection of IgG1, IgG2, IgM and IgA antibodies to rotavirus. Monoclonal antibodies to bovine immunoglobulin isotypes of proven specificity were used as conjugated or catching antibody. Five days after oral inoculation (dpi) of a 5-day-old gnotobiotic calf with rotavirus, IgM rotavirus antibodies were excreted in faeces, followed 5 days later by IgA rotavirus antibodies. The increase in IgM rotavirus antibody titre coincided with the inability to detect further rotavirus excretion. Faeces IgM and IgA rotavirus antibody titres fell to low levels within 3 weeks post infection. IgG1 and IgG2 rotavirus antibodies were not detected in faecal samples. In serum, antibodies to rotavirus of all four isotypes were detected, starting with IgM at 5 dpi. Two SPF-calves, which were fed colostrum free of rotavirus antibodies, were vaccinated with a modified live rotavirus vaccine and challenged with virulent rotavirus 6 days later. Upon vaccination, the calves showed an antibody response similar to the response of the infected gnotobiotic calf. Intestinal IgM rotavirus antibodies were excreted before or on the day of challenge and appeared to be associated with protection against challenge infection with virulent virus and rotavirus-induced diarrhoea. In 3 control calves, which were challenged only, the antibody patterns also resembled that of the gnotobiotic calf and again the appearance of IgM rotavirus antibodies coincided with the end of the rotavirus detection period. Two other groups of 3 SPF-calves were treated similarly, but the calves were fed colostrum with rotavirus antibodies during the first 48 h of life. These calves excreted passively acquired IgG1 and IgG2 rotavirus antibodies in their faeces from 2 to 6 days after birth. After vaccination, no IgM or IgA antibody activity in serum or faeces was detectable. Upon challenge, all calves developed diarrhoea and excreted rotavirus. Seven to 10 days after challenge low levels of IgM rotavirus antibody were detected for a short period. These data indicate that the intestinal antibody response of young calves to an enteric viral infection is associated with the excretion of IgM antibodies, immediately followed by IgA antibodies. This response is absent or diminished in calves with passively acquired specific antibodies which may explain the failure to induce a protective intestinal immune response by oral vaccination with modified live rotavirus of calves fed colostrum containing rotavirus antibodies.

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“…These two viruses are common causes of neonatal diarrhea. Maternal antibody dramatically decreases vaccine efficacy [69,70]. Onset of protection against disease and shedding in calves occur before secretory IgA is produced 10 days after vaccination [69], implying that the orally administered vaccine may activate innate immune system in the gastrointestinal tract and decrease disease.…”

Section: Rotavirus and Coronavirus Vaccinesmentioning

confidence: 99%