Rotavirus infection and immunity: discussion issues of clinical and immunological studies

Abstract

The article reflects the literature data on the immune response mechanisms to rotavirus infection. The authors note that innate immunity factors play the leading role in protecting the organism from rotavirus. They demonstrate that both cellular and humoral components of the immune system are important in the pathogenesis of rotavirus infection. The protective effect is based on the activation of interferon and other cytokines, as well as TLR – innate immune receptor for double-stranded rotavirus RNA. The authors also describe the age-related aspects of the immune response, which cause a higher susceptibility to rotavirus in the neonatal period and its reduction with age.