Rotavirus hospitalisation in New Zealand children under 3 years of age

Grimwood, Keith; Huang, Q. Sue; Cohet, Catherine; Gosling, I.; Hook, Sarah; Teele, David W.; Pinnock, Ralph; Nicholson, William R.; Graham, David; Farrell, Alan; Leadbitter, Philip; Lennon, Diana

doi:10.1111/j.1440-1754.2006.00829.x

Cited by 21 publications

(19 citation statements)

References 43 publications

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“…The surprising frequency of neonatal cases demonstrates that a non-trivial number of newborns might not be adequately protected by maternal antibodies (25,26). The clear excess of rotavirus disease during the first versus second year of age in our experience also conflicts with several studies where more rotavirus disease was reported in the second year rather than the first year of life (9,11,12,23).…”

Section: Discussioncontrasting

confidence: 55%

“…The median [IQR] age for the 1641 evaluable cases over the combined 12 rotavirus epidemic seasons prior to the availability of RV5 was 11 [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] months, with a full range of 0-240 months ( Figure 1). Overall, 48% of children fell outside the commonly quoted peak age range of 6-24 months, with 27% of cases occurring in infants <6 months of age and 21% of cases occurring in children >24 months of age ( Figure 2).…”

Section: Resultsmentioning

confidence: 99%

“…In the absence of a safe and effective vaccine (1-3), rotavirus has consistently been the leading cause of dehydrating gastroenteritis in infants and young children around the world (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). Virtually all children are infected at least once within the first 5 years of life, with the peak incidence widely quoted as occurring between 6 and 24 months of age (5,7,11,13,14,16,(20)(21)(22)(23).…”

Section: Introductionmentioning

confidence: 99%

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Unexpectedly high burden of rotavirus gastroenteritis in very young infants

et al. 2010

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Background: The highest incidence of rotavirus gastroenteritis has generally been reported in children 6-24 months of age. Young infants are thought to be partially protected by maternal antibodies acquired transplacentally or via breast milk. The purpose of our study was to assess the age distribution of children with confirmed community-acquired rotavirus gastroenteritis presenting to an urban referral hospital. Methods: Children presenting to The Children's Hospital of Philadelphia with acute gastroenteritis have been monitored for the presence of rotavirus antigen in the stool by ELISA (followed by genotyping if ELISA-positive) since the 1994-95 epidemic season. Results: Over the last 12 rotavirus seasons prior to the introduction of the pentavalent rotavirus vaccine in 2006, stool specimens from 1646 patients tested positive for community-acquired rotavirus infection. Gender or age was not recorded in 6 and 5 cases, respectively. Overall, 58% of the cases occurred in boys. G1 was the predominant VP7 serotype, accounting for 72% of cases. The median (IQR) age was 11 (5-21) months. A total of 790 (48%) cases occurred in children outside the commonly quoted peak age range, with 27% in infants <6 months of age and 21% in children >24 months of age. A total of 220 (13%) cases occurred during the first 3 months of life, and the highest number of episodes per month of age [97 (6%)] was observed during the second month of life. Conclusions:The incidence of community-acquired rotavirus gastroenteritis monitored over 12 seasons in the prevaccine era at a major university hospital was nearly constant for each month of age during the first year of life, revealing an unexpectedly high incidence of symptomatic rotavirus disease in infants <3 months old. A sizeable fraction of cases occurred in children too young to have been vaccinated according to current recommendations.

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Section: Discussioncontrasting

confidence: 55%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Unexpectedly high burden of rotavirus gastroenteritis in very young infants

et al. 2010

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“…Similar results were reported in a study by Mathew et al who reported high prevalence in children aged 6 -11 months and 12-23 months (32% and 42%, respectively) 5 . A study by Grimwood et al in New Zealand also showed rotavirus detection rate to be 27% in infants aged 0-5 months, 43% in infants aged 6-11 months, and 52% in the 12-35 month age group ( p < 0.001) 6 .…”

Section: Discussionmentioning

confidence: 89%

A descriptive hospital based study of rotavirus diarrhoea in children aged 6 months to 3 years

Singh¹,

Singh²,

Arora

et al. 2014

Sri Lanka J Child Health

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“…Although mortality is highest in developing countries due to poor access to healthcare, infection rates are independent of hygiene and sanitation and remain high in developed countries. In New Zealand, rotavirus infection results in >1,000 annual hospital admissions of children <3 years of age, and many more require community-based care [Grimwood et al, 2006].…”

Section: Introductionmentioning

confidence: 99%

Geographical differences in the proportion of human group A rotavirus strains within New Zealand during one epidemic season

Chandrahasen

Grimwood

Redshaw

et al. 2010

Journal of Medical Virology

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The prospect of future rotavirus vaccine programs means it is important to understand rotavirus strain diversity within New Zealand, especially if this was to influence vaccine effectiveness. The G-genotype of 359 group A rotavirus strains isolated from 416 stool samples collected from June 2005 to May 2006 (inclusive) from children less than 5 years of age in multiple centers throughout New Zealand was determined. G1 was the dominant circulating strain (55.8%) followed by G4 (21.4%), G3 (3.4%), G9 (3.4%) G2 (1.0%), and mixed infection (1.0%). Two less common strains, G6 and G8, were identified for the first time in New Zealand. P genotypes were determined for a random 10% of samples containing the common G-type strains, and all samples with an unusual G-type. All samples able to be tested contained P[8] bearing strains, except for G1P[4], G2P[4], and G8P[14] strains. Importantly, significant differences in strain frequency were found between samples collected from the North and South Islands of New Zealand. G1 was the most commonly identified strain in the North Island (81.9%); whereas G4 predominated in the South Island (39.6%). Of note, no significant differences in the relative frequency of rotavirus strains were observed between samples collected from children treated in hospital compared to samples collected from children seen by their primary healthcare provider in the community. Regional strain variation highlights the importance of ensuring multi-center surveillance to help monitor program effectiveness when rotavirus vaccines are introduced into New Zealand's national childhood immunization schedule.

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Rotavirus hospitalisation in New Zealand children under 3 years of age

Abstract: Rotavirus diarrhoea is an important, potentially vaccine-preventable cause of hospitalisation in New Zealand children, especially during winter and spring seasons.

Cited by 21 publications

References 43 publications

Unexpectedly high burden of rotavirus gastroenteritis in very young infants

Unexpectedly high burden of rotavirus gastroenteritis in very young infants

A descriptive hospital based study of rotavirus diarrhoea in children aged 6 months to 3 years

Geographical differences in the proportion of human group A rotavirus strains within New Zealand during one epidemic season

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