Rotavirus G9P[4] in 3 Countries in Latin America, 2009–2010

Quaye, Osbourne; McDonald, Sharla; Esona, Mathew D.; Lyde, Freda C.; Mijatovic-Rustempasic, Slavica; Roy, Sunando; Banegas, Dina J. Castro; Quiñonez, Yolanda Mencos; Chinchilla, Blanca; Santiago, Fabián Gómez; Lozano, Herlinda García; Rey-Benito, Gloria; Oliveira, Lúcia Helena de; Gentsch, Jon R.; Bowen, Michael D.

doi:10.3201/eid1908.130288

Cited by 46 publications

(39 citation statements)

References 10 publications

(12 reference statements)

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“…These strains have undergone natural intergenogroup reassortment, as was reported in India and Germany [18,39]. The G9P4 genotype was identified in Brazil in the 1990s, in Honduras in 2009 and in Mexico and Guatemala in 2010 [8,40,41]. In our study, it appears that this genotype was the result of the reassortment between G2P4 and G9P6, strains that were reported in Cuba previously [8].…”

Section: Discussionsupporting

confidence: 48%

Detection of rotavirus and other enteropathogens in children hospitalized with acute gastroenteritis in Havana, Cuba

et al. 2015

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The aim of the study was to diagnose infections with rotavirus and other enteric pathogens in children under five years old with acute gastroenteritis and to identify the most common epidemiological and clinical characteristics of these pathogens. The study was conducted using 110 stool samples from the same number of children under five years old who were inpatients at three paediatric hospitals in Havana, Cuba, between October and December 2011. The samples were tested for rotavirus and other enteric pathogens using traditional and molecular microbiological methods. Pathogens were detected in 85 (77.3 %) of the children. Rotavirus was the most commonly found, appearing in 54.5 % of the children, followed by bacteria (29 %) and parasites (10.9 %). Other viral pathogens detected included adenovirus (6.4 %) and astrovirus (3.6 %). In rotavirus-positives cases, at least one other pathogen was detected, usually a bacterium (26.6 %). More than three episodes of watery diarrhea in 24 hours were observed in 78.3 % of the cases. Dehydration was found in 30 (50 %) rotavirus-positive children, of whom seven (11.6 %) were transferred to an intensive care unit due to complications of metabolic acidosis. Rotavirus was most commonly observed among children under 12 months old (65 %). The highest incidence of infection occurred in children who were under the care of a relative at home (78.3 %), had not been breastfed (65 %), or had been breastfed for less than six months (28.3 %). The genotype combinations most frequently found were G9P8 (28.3 %) and G1P8 (10 %). This study demonstrates the presence of rotavirus and other enteric pathogens as causes of gastroenteritis in hospitalized infants and young children in Cuba.

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Section: Discussionsupporting

confidence: 48%

Detection of rotavirus and other enteropathogens in children hospitalized with acute gastroenteritis in Havana, Cuba

et al. 2015

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“…In Mexico, G9 was detected between 1998 and 2001 in combination with genotype P[6] and in cases of mixed infections of G1 + 9P[6 + 8] [20]. In 2010, the combination G9P[4] was identified in 23 states in Mexico [13,21]. The G9P[4] genotype has also been reported in other countries in Latin-America since the 1990s [13].…”

Section: Figmentioning

confidence: 92%

“…The strain Mex1157 was collected in a 2009-2010 outbreak that occurred in several states of Mexico, especially in Chiapas [13]. The strain LB1562, collected in 2010 in Long Beach, CA, USA, had a 100% identity with the partial VP7 gene of the strains isolated in Mexico during that same year [28] and with 8 strains collected during 2011 in the present report (represented by strain HM34 in Fig.…”

Section: Figmentioning

confidence: 99%

“…In 2010, the combination G9P[4] was identified in 23 states in Mexico [13,21]. The G9P[4] genotype has also been reported in other countries in Latin-America since the 1990s [13]. …”

Section: Figmentioning

confidence: 99%

“…During the 1990s, the genotypes that were more frequently reported in the different states of Mexico were G3, G1, P[8], and P[4], and combinations thereof [10,11,12]. However, in recent years, genotype G9 has emerged, mostly in combination with genotype P[4] [13]. Since information of circulating genotypes is scarce in Northwestern Mexico, we report herein the genotype of strains causing diarrhea in children aged <5 years with acute gastroenteritis and diagnosed with RVA by antigen-detection immunoassay that were treated at the Children's Hospital of the State of Sonora (HIES) between February and March 2011.…”

Section: Figmentioning

confidence: 99%

See 2 more Smart Citations

Predominance of G9P[4] Rotavirus from Children with Acute Gastroenteritis in Northwestern Mexico

Félix-Valenzuela¹,

Cooley-García²,

Cano-Rangel³

et al. 2016

Intervirology

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In Mexico, group A rotavirus (RVA) infections remain the most common cause of severe dehydrating diarrhea in children. This study was conducted to examine the circulating RVA strains in the northwest region of Mexico. RVA strains collected from stool samples of children were genotyped, and their partial sequences were analyzed. RT-PCR of the VP4 and VP7 genes showed the partial G9P[4] genotype in all the samples. Sequencing and phylogenetic analysis of the partial VP7 gene amplicons of 10 strains showed that they clustered in the RVA G9 lineage III, and 7 of them showed 100% identity with the reference strain LB1562, which was collected in the USA 2 years earlier. The amino acid sequences of the VP7 and VP4 antigenic regions were highly conserved between the analyzed RVA strains. Active surveillance is important for monitoring the emergence of RVA strains and their impact on cases of gastroenteritis.

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Detection and characterization of a human G9P[4] rotavirus strain in Japan

Yamamoto

Kaida

Ono³

et al. 2015

Journal of Medical Virology

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In a surveillance system in Osaka City, Japan, 48 sporadic rotavirus A (RVA) infections were detected during 2008/2009-2011/2012 seasons. The G/P-genotypes of detected RVAs were G1P[8], G2P[4], G3P[8], G9P[4], and G9P[8]. Although G9P[4] is a rare genotype that had not been reported in Japan, it was the second most prevalent genotype, following G1P[8], and accounted for 35.3% of RVA cases in the 2011/2012 season. Further genotyping revealed that the G9P[4] strain had genotype 2 internal protein genes except for NSP3: G9-P[4]-I2-R2-C2-M2-A2-N2-T1-E2-H2. Among detected RVA strains, G9P[4] and some G9P[8] strains shared high nucleotide identity in VP7 and NSP3 genes. Phylogenetic and BLAST search analyses showed that the G9P[4] strain in Japan shared high nucleotide identity in genotype 2 genes with common G2P[4] strains circulating globally, but was distinct from other G9P[4] strains circulating worldwide. These results suggest that the G9P[4] strain in Japan may have emerged through an independent reassortment between G9P[8] and G2P[4]. Finally, the role of NSP3 protein in the circulating RVA from an amino acid comparison between T1- and T2-type NSP3 is discussed. These findings provide an important insight into less problematic combinations of circulating RVA genes derived from different genotypes.

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Rotavirus G9P[4] in 3 Countries in Latin America, 2009–2010

Cited by 46 publications

References 10 publications

Detection of rotavirus and other enteropathogens in children hospitalized with acute gastroenteritis in Havana, Cuba

Detection of rotavirus and other enteropathogens in children hospitalized with acute gastroenteritis in Havana, Cuba

Predominance of G9P[4] Rotavirus from Children with Acute Gastroenteritis in Northwestern Mexico

Detection and characterization of a human G9P[4] rotavirus strain in Japan

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