Rotaviral Infection and Intestinal Lactase Level

Sc, Arya

doi:10.1093/infdis/150.5.791

Cited by 8 publications

(5 citation statements)

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“…[31][32][33] CC/GG being associated with lactase non-persistence and therefore development of LI. 6 Frequent gastrointestinal infections in developing countries like India, which may cause LI at least temporarily, 34,35 might also contribute to a high frequency of LI among these subjects. Most previous studies used either LTT or LHBT to diagnose LI.…”

Section: Discussionmentioning

confidence: 99%

Lactose intolerance in patients with irritable bowel syndrome from northern India: A case–control study

Gupta

Ghoshal

Misra

et al. 2007

J of Gastro and Hepatol

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Section: Discussionmentioning

confidence: 99%

Lactose intolerance in patients with irritable bowel syndrome from northern India: A case–control study

Gupta

Ghoshal

Misra

et al. 2007

J of Gastro and Hepatol

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“…Under normalcy, healthy enterocytes secrete lactase into the small intestine that helps in lactose metabolism, but children with rotavirus infection are unable to tolerate milk due to lactase deficiency that can last for several weeks [ 93 ]. Such a child may experience recurrence of diarrhea after milk reintroduction into the child’s diet as a result of bacterial fermentation of the lactose in the gut [ 94 ].…”

Section: Pathogenesis Of Rotavirus Infectionmentioning

confidence: 99%

Rotaviruses: From Pathogenesis to Disease Control—A Critical Review

Omatola

Olaniran

2022

Viruses

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Since their first recognition in human cases about four decades ago, rotaviruses have remained the leading cause of acute severe dehydrating diarrhea among infants and young children worldwide. The WHO prequalification of oral rotavirus vaccines (ORV) a decade ago and its introduction in many countries have yielded a significant decline in the global burden of the disease, although not without challenges to achieving global effectiveness. Poised by the unending malady of rotavirus diarrhea and the attributable death cases in developing countries, we provide detailed insights into rotavirus biology, exposure pathways, cellular receptors and pathogenesis, host immune response, epidemiology, and vaccination. Additionally, recent developments on the various host, viral and environmental associated factors impacting ORV performance in low-and middle-income countries (LMIC) are reviewed and their significance assessed. In addition, we review the advances in nonvaccine strategies (probiotics, candidate anti-rotaviral drugs, breastfeeding) to disease prevention and management.

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“…[18] . So, children with rotavirus infection are unable to tolerate milk, who may experience recurrence of diarrhea after milk reintroduction into the child's diet as a result of bacterial fermentation of the lactose in the gut [19] . Therefore, for those children who have already developed diarrhea, special attention should be paid to the secondary stimulation of the fragile intestinal tract after the intake of lactose-enriched milk powder.…”

Section: Food Science and Human Wellnessmentioning

confidence: 99%

Lactose-free milk powder can effectively relieve diarrhea symptoms in weaning SD rats and children

Liu¹,

Han²,

Li³

et al. 2024

Food Science and Human Wellness

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Diarrhea has become the leading cause of illness and death among infants and young children in developing countries. Clinically, patients with diarrhea showed damaged intestinal epithelial villi, usually accompanied by lactase defi ciency. In this study, we evaluated the therapeutic effects of lactose-free milk powder on rats and children with diarrhea. Antibiotic-associated diarrhea (AAD) model was established by gavage with antibiotic mixture in SD rats, followed by administration of milk powder containing lactose or not. The results showed that lactose-free milk powder ameliorated AAD-related diarrhea symptoms, and accelerated the recovery from diarrhea. And 16S sequencing results indicated lactose-free milk powder contributed to increase the αand β-diversity of intestinal fl ora, and restore the intestinal microbiota disorder. In conclusion, our data demonstrate that lactose-free milk powder could alleviate diarrhea by restoring gut microbiota and intestinal barrier function.

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Rotaviral Infection and Intestinal Lactase Level

Cited by 8 publications

References 0 publications

Lactose intolerance in patients with irritable bowel syndrome from northern India: A case–control study

Lactose intolerance in patients with irritable bowel syndrome from northern India: A case–control study

Rotaviruses: From Pathogenesis to Disease Control—A Critical Review

Lactose-free milk powder can effectively relieve diarrhea symptoms in weaning SD rats and children

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