Rotator Cuff Tear Susceptibility Is Associated With Variants in Genes Involved in Tendon Extracellular Matrix Homeostasis

Figueiredo, Eduardo Antônio de; Loyola, Leonor Casilla; Belangero, Paulo Santoro; Ribeiro‐dos‐Santos, Ândrea; Santos, Sidney Emanuel Batista dos; Cohen, Carina; Wajnsztejn, André; Oliveira, Adrielle Martins de; Smith, Marı́lia de Arruda Cardoso; Pochini, Alberto de Castro; Andreoli, Carlos Vicente; Ejnisman, Benno; Cohen, Moisés; Leal, Mariana Ferreira

doi:10.1002/jor.24455

Cited by 27 publications

(39 citation statements)

References 43 publications

(65 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Figueiredo et al, 60 identified genetic factors associated with susceptibility of rotator cuff injury, reinforcing the role of extracellular matrix homeostasis in this context.…”

Section: Postoperative Factorsmentioning

confidence: 89%

See 1 more Smart Citation

A cicatrização do manguito rotador

Filho

Coelho

2020

Rev Bras Ortop (Sao Paulo)

View full text Add to dashboard Cite

ResumoO presente artigo aborda de forma ampla os aspectos que interferem no processo de cicatrização do manguito rotador. São considerados hábitos de vida como tabagismo e alcoolismo, fatores sistêmicos como diabetes mellitus, hipertensão arterial e obesidade bem como fatores locais, dentre os quais aqueles relacionados ao pré, per e pós operatório. A partir de uma extensa revisão da literatura, com a citação de 60 artigos científicos tanto da literatura ocidental como oriental, os autores pretendem aprofundar no tema trazendo para a prática médica condutas embasadas em novos conceitos estabelecidos.

show abstract

“…Figueiredo et al, 60 identified genetic factors associated with susceptibility of rotator cuff injury, reinforcing the role of extracellular matrix homeostasis in this context.…”

Section: Postoperative Factorsmentioning

confidence: 89%

“…Figueiredo et al 60 identificaram fatores genéticos associados à susceptibilidade da lesão do manguito rotador, reforçando o papel da homeostase da matriz extracelular nesse contexto.…”

Section: Fatores Genéticosunclassified

A cicatrização do manguito rotador

Filho

Coelho

2020

Rev Bras Ortop (Sao Paulo)

View full text Add to dashboard Cite

show abstract

“…A growing body of evidence, from non-cancer-related conditions, supports the role of polymorphisms within genes encoding structural and regulatory extracellular matrix (ECM) proteins in modulating susceptibility to shoulder pathology [8][9][10][11]. Although no associations between polymorphisms in proteoglycan encoding genes and non-cancer-related shoulder conditions have been reported to date, proteoglycans are important ECM components whose expression levels are altered in such conditions [12,13].…”

Section: Introductionmentioning

confidence: 99%

Regulatory VCAN Polymorphism is Associated with Shoulder Pain and Disability in Breast Cancer Survivors

Mafu

September

Shamley

2021

Preprint

View full text Add to dashboard Cite

Background and PurposeShoulder morbidity following breast cancer treatment is multifactorial. Despite several treatment- and patient-related factors implicated, unexplained inter-individual variability exists in the development of such morbidity. Given the paucity of relavant genetic studies, we investigate the role of polymorphisms in candidate proteoglycan genes.Patients and methodsWe conducted a cross-sectional study on 254 South African breast cancer survivors, to evaluate associations between shoulder pain/disability and ten single nucleotide polymorphisms (SNPs) within four proteoglycan genes: ACAN (rs1126823 G>A, rs1516797 G>T, rs2882676 A>C); BGN (rs1042103 G>A, rs743641 A>T, rs743642 G>T); DCN rs516115 C>T; and VCAN (rs11726 A>G, rs2287926 G>A, rs309559). Participants were grouped into no–low and moderate–high shoulder pain/disability based on total pain/disability scores: <30 and ≥30, respectively using the shoulder pain and disability index (SPADI).ResultsThe GG genotype of VCAN rs11726 was independently associated with an increased risk of being in the moderate to high shoulder pain (P=0.005, OR=2.326, 95% CI=1.259 - 4.348) or disability (P=0.011, OR=2.439, 95% CI=1.235 - 4.762) categories, after adjusting for participants’ age. In addition, the T-T-G inferred allele combination of BGN (rs74364 - rs743642) - VCAN rs11726 was associated with an increased risk of being in the moderate to high shoulder disability category (0=0.002, OR=2.347, 95% CI=1.215 - 4.534).ConclusionOur study is first to report that VCAN rs11726, independently or interacting with BGN polymorphisms, is associated with shoulder pain or disability in breast cancer survivors. Whereas our findings suggest an involvement of proteoglycans in the etiology of shoulder pain/disability, further studies are recommended.

show abstract

“…A growing body of evidence, from non-cancer-related conditions, supports the role of polymorphisms within genes encoding structural and regulatory extracellular matrix (ECM) proteins in modulating susceptibility to shoulder pathology [ 8 – 11 ]. Although no associations between polymorphisms in proteoglycan-encoding genes and non-cancer-related shoulder conditions have been reported to date, proteoglycans are important ECM components whose expression levels are altered in such conditions [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Regulatory VCAN polymorphism is associated with shoulder pain and disability in breast cancer survivors

2021

View full text Add to dashboard Cite

Background and purpose Shoulder morbidity following breast cancer treatment is multifactorial. Despite several treatment- and patient-related factors being implicated, unexplained inter-individual variability exists in the development of such morbidity. Given the paucity of relavant genetic studies, we investigate the role of polymorphisms in candidate proteoglycan genes. Patients and methods We conducted a cross-sectional study on 254 South African breast cancer survivors, to evaluate associations between shoulder pain/disability and ten single nucleotide polymorphisms (SNPs) within four proteoglycan genes: ACAN (rs1126823 G>A, rs1516797 G>T, rs2882676 A>C); BGN (rs1042103 G>A, rs743641 A>T, rs743642 G>T); DCN rs516115 C>T; and VCAN (rs11726 A>G, rs2287926 G>A, rs309559). Participants were grouped into no–low and moderate–high shoulder pain/disability based on total pain/disability scores: < 30 and ≥ 30, respectively using the Shoulder Pain and Disability Index (SPADI). Results The GG genotype of VCAN rs11726 was independently associated with an increased risk of being in the moderate-to-high shoulder pain (P = 0.005, OR = 2.326, 95% CI = 1.259–4.348) or disability (P = 0.011, OR = 2.439, 95% CI = 1.235–4.762) categories, after adjusting for participants’ age. In addition, the T-T-G inferred allele combination of BGN (rs74364–rs743642)–VCAN rs11726 was associated with an increased risk of being in the moderate-to-high shoulder disability category (0 = 0.002, OR = 2.347, 95% CI = 1.215–4.534). Conclusion Our study is first to report that VCAN rs11726, independently or interacting with BGN polymorphisms, is associated with shoulder pain or disability in breast cancer survivors. Whereas our findings suggest an involvement of proteoglycans in the etiology of shoulder pain/disability, further studies are recommended.

show abstract

Rotator Cuff Tear Susceptibility Is Associated With Variants in Genes Involved in Tendon Extracellular Matrix Homeostasis

Cited by 27 publications

References 43 publications

A cicatrização do manguito rotador

A cicatrização do manguito rotador

Regulatory VCAN Polymorphism is Associated with Shoulder Pain and Disability in Breast Cancer Survivors

Regulatory VCAN polymorphism is associated with shoulder pain and disability in breast cancer survivors

Contact Info

Product

Resources

About