Rotator cuff tear and sarcopenia: are these related?

Chung, Seok Won; Yoon, Jong Pil; Oh, Kyung-Soo; Kim, Hyung Sup; Kim, Young Gun; Lee, Hyun-Joo; Jeong, Won-Ju; Kim, Dong-Hyun; Lee, Jong Soo; Yoon, Jee Wook

doi:10.1016/j.jse.2016.02.008

Cited by 19 publications

(12 citation statements)

References 38 publications

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“…However, failure in rotator cuff healing remains one of the most common and well-known complications of surgical repair [3, 4]. Several factors associated with rotator cuff muscle changes, such as aging [5], apoptosis [6], muscle degeneration [7], sarcopenia [8], muscle atrophy [9], and muscle fatty infiltration [10], have been demonstrated to be associated with rotator cuff tear. Further, these anatomical and physiological rotator cuff muscle changes reportedly result in healing failure and poor functional outcomes after rotator cuff repair [11–13].…”

Section: Introductionmentioning

confidence: 99%

Gene Expression Patterns Analysis in the Supraspinatus Muscle after a Rotator Cuff Tear in a Mouse Model

Lee

Kim

et al. 2018

BioMed Research International

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Rotator cuff tear is a muscle-tendinous injury representative of various musculoskeletal disorders. In general, rotator cuff tear occurs in the tendon, but it causes unloading of the muscle resulting in muscle degeneration including fatty infiltration. These muscle degenerations lead to muscle weakness, pain, and loss of shoulder function and are well known as important factors for poor functional outcome after rotator cuff repair. Given that rotator cuff tear in various animal species results in similar pathological changes seen in humans, the animal model can be considered a good approach to understand the many aspects of the molecular changes in injured muscle. To comprehensively analyze changes in gene expression with time following a rotator cuff tear, we established a rotator cuff tear in mouse supraspinatus tendon of shoulder. At weeks 1 and 4 after the tear, the injured muscles were harvested for RNA isolation, and microarray analysis was performed. Expression patterns of genes belonging to 10 muscle physiology-related categories, including aging, apoptosis, atrophy, and fatty acid transport, were analyzed and further validated using real-time PCR. A total of 39,429 genes were analyzed, and significant changes in expression were observed for 12,178 genes at 1 week and 2,370 genes at 4 weeks after the tear. From the list of top 10 significantly up- and downregulated genes at the 2 time periods and the network evaluation of relevant genes according to the 10 categories, several important genes in each category were observed. In this study, we found that various genes are significantly altered after rotator cuff tear, and these genes may play key roles in controlling muscle degeneration after a rotator cuff tear.

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Section: Introductionmentioning

confidence: 99%

Gene Expression Patterns Analysis in the Supraspinatus Muscle after a Rotator Cuff Tear in a Mouse Model

Lee

Kim

et al. 2018

BioMed Research International

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“…However, they even could not explain mechanism of relationship and merely presented results. Our initial assumption, lower muscle mass in DRF than RCT, could be wrong according to Chung et al[ 37 ]. Overall, sarcopenia of upper extremity patients are not fully understood.…”

Section: Discussionmentioning

confidence: 96%

“…[ 18 19 37 ] Especially, only one recent study is available about relationship between sarcopenia and RCT. [ 37 ] Chung et al[ 37 ] reported sarcopenia was more severe in patients with a chronic symptomatic full-thickness RCT than in the age- and sex-matched control population. However, they even could not explain mechanism of relationship and merely presented results.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Bone Mineral Density and Appendicular Lean Body Mass between Osteoporotic Distal Radius Fracture and Degenerative Rotator Cuff Tear in Women Patients

et al. 2017

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BackgroundAuthors assessed lean body mass (fat free tissue), upper and lower, and bone mineral density (BMD) in patients of osteoporotic bone distal radius fracture (DRF) and degenerative rotator cuff tear (RCT) patients of shoulder. We predict inferior muscle mass and osteoporosis are more frequent in DRF group than RCT group.MethodsBetween January 2016 and June 2017, overall 38 of DRF and 30 of RCT were eligible for this retrospective comparison study after excluding of patients with compounding factors. BMD and other body composition, fat and lean body mass, were assessed with a single dual energy X-ray absorptiometry in one hospital.ResultsT-score of spine were −2.2 and −1.6 in DRF and RCT patients with significant difference (P=0.040). Final BMD score, lower score of patient between spine and femoral score, of both group also presented difference with significance, −2.4 of DRF and −1.9 of RCT patients (P=0.047). Diagnosis of osteoporosis was confirmed in 19 patients (50%) from DRF compared with 9 patients (30%) from RCT. The mean lean soft tissue mass of the arm was 3.7 kg and 3.8 kg in the DRF and RCT, respectively, without significant difference (P=0.882). The mean lean body mass of the leg was 11.0 kg and 10.5 kg in the DRF and RCT, respectively, without significant difference (P=0.189). The relative overall appendicular lean mass was not significantly different between groups.ConclusionsEven though BMD difference, we did not find muscle mass difference between DRF and RCT patients.

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“…With the onset of advancing age, muscle tissue is gradually lost, resulting in diminished mass and strength; this condition is referred to as sarcopenia [ 21 , 23 ]. One study presented that patients with cuff tears have sarcopenia, and patients with large to massive tears have a significantly inferior sarcopenic index than those with small to medium tears [ 24 ]. They measured the whole-body muscle mass as per the Janssen [ 25 ] method of bioelectrical impedance analysis equation, which is different from the analysis used in our current paper, in that we only calculated the subscapularis muscle [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…One study presented that patients with cuff tears have sarcopenia, and patients with large to massive tears have a significantly inferior sarcopenic index than those with small to medium tears [ 24 ]. They measured the whole-body muscle mass as per the Janssen [ 25 ] method of bioelectrical impedance analysis equation, which is different from the analysis used in our current paper, in that we only calculated the subscapularis muscle [ 24 ]. Another paper explains that rotator cuff atrophy is related to increasing age and not to tear severity.…”

Section: Discussionmentioning

confidence: 99%

The Volume of Subscapularis Muscle Remains Unaffected by Supraspinatus Tendon Tears: Three-dimensionally Reconstructed Magnetic Resonance Imaging Analysis

Jun

Moon

Bhardwaj

et al. 2019

Clin Shoulder Elbow

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Background: This study aimed to compare the subscapularis muscle volume between the intact groups (group I) and supraspinatus tendon tear groups (group T) based on the sex and three different age groups.Methods: Subjects with a group I and subjects with group T without any other lesions were retrospectively evaluated from among patients who received a magnetic resonance imaging (MRI) scan between January 2011 and December 2013. The MRI scans were studied by a consultant radiologist. The subscapularis muscle volume was compared according to the age and sex; the age groups were categorized as patients in their 40s, 50s, and 60s. The volume of subscapularis muscle was measured by three-dimensional reconstructed images acquired through the axial section of 1.5T MRI.Results: No statistically significant differences were observed between subscapularis muscle volume of the group I and group T, except for male patients in their 50s (group I: 100,650 mm3 vs. group T: 106,488 mm3) and 60s (group I: 76,347 mm3 vs. group T: 99,549 mm3) (p<0.05). Males had a larger mean volume of subscapularis muscle than females, and the subscapularis muscle volume decreased in a linear manner with increasing age.Conclusions: Decrease in subscapularis muscle volume was observed with increasing age, and the impact of supraspinatus tear on subscapularis muscle volume is age and sex dependent.

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Rotator cuff tear and sarcopenia: are these related?

Cited by 19 publications

References 38 publications

Gene Expression Patterns Analysis in the Supraspinatus Muscle after a Rotator Cuff Tear in a Mouse Model

Gene Expression Patterns Analysis in the Supraspinatus Muscle after a Rotator Cuff Tear in a Mouse Model

Comparison of Bone Mineral Density and Appendicular Lean Body Mass between Osteoporotic Distal Radius Fracture and Degenerative Rotator Cuff Tear in Women Patients

The Volume of Subscapularis Muscle Remains Unaffected by Supraspinatus Tendon Tears: Three-dimensionally Reconstructed Magnetic Resonance Imaging Analysis

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