Rotator cuff repair: a review of surgical techniques, animal models, and new technologies under development

Deprés-Tremblay, Gabrielle; Chevrier, Anik; Snow, Martyn; Hurtig, Mark B.; Rodeo, Scott A.; Buschmann, Michael D.

doi:10.1016/j.jse.2016.06.009

Cited by 128 publications

(97 citation statements)

References 77 publications

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“…While we typically observe substantial tendon retraction in mice that have undergone this injury at the timepoints that we studied, it is unclear whether this acute mechanical unloading injury has the same chronological impact on muscle stem cells as a chronic tendinous injury. However, numerous studies using this mouse model have shown the development of similar muscle pathology to that seen in human RC tears 4,6,22 . Second, direct functional testing of the MuSC population is necessary in the setting of injury-induced atrophy in order to better assess the capacity of these cells to participate in myotube formation and muscle healing following injury.…”

Section: Discussionmentioning

confidence: 75%

“…However, numerous studies using this mouse model have shown the development of similar muscle pathology to that seen in human RC tears. 4,6,22 Second, direct functional testing of the MuSC population is necessary in the setting of injury-induced atrophy in order to better assess the capacity of these cells to participate in myotube formation and muscle healing following injury. Specifically, this study denoted cells as "active" if they expressed either the marker of proliferation, Ki67, or the marker of myogenic differentiation, Myod1.…”

Section: Discussionmentioning

confidence: 99%

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Muscle stem cell activation in a mouse model of rotator cuff injury

Davies

Garcia

Tamaki

et al. 2018

Journal Orthopaedic Research

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Rotator cuff (RC) tears are frequently complicated by muscle atrophy. Muscle stem cells (MuSCs) repair damaged myofibers following injury, but their role in the prevention or pathogenesis of atrophy following RC tears remains undefined. We hypothesized that the RC MuSC population would be affected by supraspinatus (SS) and infraspinatus (IS) tendon transection (TT) compared to uninjured muscle in a mouse model of RC tear. C57BL6/J mice underwent unilateral SS and IS TT and contralateral sham surgery. At 3, 8, or 14 weeks after injury, mice were euthanized, and SS and IS were harvested for FACS sorting of CD31-/CD45-/Sca1-/ITGa7+/VCAM+ MuSCs or histological analysis. Ki-67+ MuSCs from injured muscle increased 3.4-fold at 3 weeks (p = 0.03) and 8.1-fold at 8 weeks (p = 0.04) following TT injury, but returned to baseline by 14 weeks (p = 0.91). Myod1 remained upregulated 3.3-fold at 3 weeks (p = 0.03) and 2.0-fold at 14 weeks (p = 0.0003), respectively. Myofiber cross-sectional area was decreased at both 3 and 14 weeks after injury, but the number of MuSCs per fiber remained relatively constant at 3 (p = 0.3) and 14 (p = 0.6) weeks after TT. In this study, we characterized the longitudinal effect of RC tendon injury on the MuSC population in supraspinatus and infraspinatus muscles. MuSCs are transiently activated, and are not depleted, in spite of persistent muscle atrophy. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1370-1376, 2018.

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Muscle stem cell activation in a mouse model of rotator cuff injury

Davies

Garcia

Tamaki

et al. 2018

Journal Orthopaedic Research

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“…Notably, this study was conducted on a rabbit model rather than the complex condition of a tendon in a human. 55,56 Another limitation of our study is that the last time point we selected is 12 weeks after the operation; it is desirable to carry out histological observation of the tendon to bone junctions even up to 1 year after surgery. 20 Finally, the underlying mechanisms of the promotion of BMSC differentiation and the enhancement of the tendon to bone healing by the nanostructured PLGA-GO membranes are unknown and need to be clarified.…”

Section: Su Et Almentioning

confidence: 99%

<p>Promoting tendon to bone integration using graphene oxide-doped electrospun poly(lactic-co-glycolic acid) nanofibrous membrane</p>

Su¹,

Wang²,

Jiang³

et al. 2019

IJN

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Background These normal entheses are not reestablished after repair despite significant advances in surgical techniques. There is a significant need to develop integrative biomaterials, facilitating functional tendon-to-bone integration. Materials and methods We fabricated a highly interconnective graphene oxide-doped electrospun poly(lactide-co-glycolide acid) (GO-PLGA) nanofibrous membrane by electrospinning technique and evaluated them using in vitro cell assays. Then, we established rabbit models, the PLGA and GO-PLGA nanofibrous membranes were used to augment the rotator cuff repairs. The animals were killed postoperatively, which was followed by micro-computed tomography, histological and biomechanical evaluation. Results GO was easily mixed into PLGA filament without changing the three dimensional microstructure. An in vitro evaluation demonstrated that the PLGA membranes incorporated with GO accelerated the proliferation of BMSCs and furthered the Osteogenic differentiation of BMSCs. In addition, an in vivo assessment further revealed that the local application of GO-PLGA membrane to the gap between the tendon and the bone in a rabbit model promoted the healing enthesis, increased new bone and cartilage generation, and improved collagen arrangement and biomechanical properties in comparison with repair with PLGA only. Conclusion The electrospun GO-PLGA fibrous membrane provides an effective approach for the regeneration of tendon to bone enthesis.

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“…The main goal of the rotator cuff tear repair surgery is to alleviate pain, and the improvement of shoulder function is treated as a second priority. In 20 to 95% of patients, the repair of the rotator cuff may be unsuccessful, depending on factors such as tear size, time elapsed from the injury, fat atrophy and surgical technique (5 (6,7). Arthroscopic repair is a standard treatment for rotator tear, which is currently applied for all types of small or large tears (8,9).…”

Section: Introductionmentioning

confidence: 99%

“…Despite the obvious advantages of the arthroscopic rotator cuff tear repair, there are not conclusive evidences about the superiority of this method over open surgery, with many non-randomized studies indicating similar effectiveness of these two techniques (5,8). Further studies are needed to make better comparisons and more reasonable decisions about the adoption of the best therapeutic procedure for patients.…”

Section: Introductionmentioning

confidence: 99%

A Comparative Study on the Clinical Results of Arthroscopic Rotator Cuff Repair and Open Repair Surgery

et al. 2018

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Introduction: Despite the obvious advantages of arthroscopic rotator cuff repair, there are no definitive evidences regarding the superiority of this method over open surgery. The aim of this study is to compare the results of arthroscopic rotator cuff repair and open repair surgery. Methods: A total of 52 patients referring to a general university hospital were included in the study and assigned to two groups of arthroscopic repair and open repair. Demographic information of patients and the presence of any underlying disease and the grade of rotator cuff tear were recorded. The pain scores of the patients were measured three times, before, 48 h after surgery and 6-month follow-up, using the VAS system. To evaluate the clinical performance of patients, UCLA scoring system (only 6 months after the surgery) and Constant (before and 6 months after surgery) were utilized. Results: 32 patients were assigned to the open repair surgery and 20 to the arthroscopic repair group. The two groups were not significantly different in terms of pain variables, 48 hours after operation (P = 0.054) and 6 months after operation (P = 0.638), constant score 6 months after operation (P = 0.157) and UCLA shoulder rating scale 6 months after surgery (P = 0.167). Moreover, there was not any significant difference between the two groups with regard to these variables before surgery. Conclusions:The results of this study showed that arthroscopic rotator cuff repair was a safe procedure which was as effective as open repair surgery. Also, reduced postoperative pain was one of the advantages of this method noted in the present study, although the long-term severity of pain in this method was not significantly different from the pain of patients undergoing open surgery.

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Rotator cuff repair: a review of surgical techniques, animal models, and new technologies under development

Cited by 128 publications

References 77 publications

Muscle stem cell activation in a mouse model of rotator cuff injury

Muscle stem cell activation in a mouse model of rotator cuff injury

<p>Promoting tendon to bone integration using graphene oxide-doped electrospun poly(lactic-co-glycolic acid) nanofibrous membrane</p>

A Comparative Study on the Clinical Results of Arthroscopic Rotator Cuff Repair and Open Repair Surgery

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