Abstract.The interaction between ammonia and helium has attracted considerable interest over many years, partly because of the observation of interstellar ammonia. The rate coefficients of NH3-He scattering are an important ingredient for numerical modeling of astrochemical environments. Another, though quite different application in which the NH3-He interaction can play an important role is the doping of helium clusters with NH3 molecules to perform high-resolution spectroscopy. Such experiments are directed on the detection of non-classical response of molecular rotation in helium clusters addressing fundamental questions related to the microscopic nature of superfluidity. High-resolution spectroscopy on the NH3-He complex is an important tool for increasing our understanding of intermolecular forces between NH3 and He.The experimental spectra of NH3-He would be of great importance to test the accuracy of available potential energy surfaces used in the analysis of the role of resonances in low energy collisions [1,2]. The rate coefficients of NH3-He scattering are an important ingredient for numerical modeling of astrochemical environments. This is one of the reasons why NH3-He interactions have been studied experimentally and theoretically by several groups (see [1,2] and Refs. therein). Recently, a new four-dimensional potential energy surface (PES), based on a high-quality fit of 4180 ab initio points, was calculated [1]. The potential has a well depth of De = 35.08 cm , which is to be compared with the well depth of 33.46 cm −1 for the earlier potential of Hodges and Wheatley [3]. Although this difference is not very large, it was found that small differences in the potential can have profound consequences for the observed resonance structures at low scattering energies. High-resolution spectra of the NH3-He complex could be an additional test of the PES's quality, but these spectra have not been observed yet. High-resolution infrared and/or microwave spectra of the related NH3-Ar (see [4] and Refs. there) and NH3-Ne [5] in the gas phase have been reported, but no comparable data exist for helium.A very different experiment in which the NH3-He interaction plays an important role, is the trapping of NH3 molecules inside He nanodroplets to perform high resolution spectroscopy. Such experiments are directed on the detection of a superfluid response of molecular rotation in helium clusters [6,7]. It was shown that the lighter probe molecules allow one to measure the effective inertia of He clusters while maintaining a maximum