Abstract. The generic equilibrium configuration of the nighttime midlatitude ionosphere consists of an F layer held up against gravity by winds and/or electric fields, and a sporadic E (E s ) layer located by a sheared wind field, which experiences the same electric fields as the F layer. This configuration is subject to two large-scale (e.g. >10 km) "layer instabilities": one of the F layer known as the Perkins instability, and another of the E s layer which has been called the E s layer instability. Electric fields on scales larger than (about) 10 km map very efficiently between the E s and F layers, and the two instabilities have a similar geometry, allowing them to interact with one another. As shown through a linear growth rate analysis, the two most important parameters governing the interaction are the relative horizontal velocity between the E s and F layers, and the integrated conductivity ratio H / P F , where H and P F are the field line integrated Hall conductivity of the E s layer, and the field line integrated Pedersen conductivity of the F layer, respectively. For both large and small relative velocities the growth rate was found to be more than double that of the Perkins instability alone, when