Rosuvastatin Reduces Blood Viscosity in Patients with Acute Coronary Syndrome

Jung, Lae Young; Lee, Sang Rok; Jung, Joon Min; Kim, Yi Shik; Lee, Sun Hwa; Rhee, Kyoung Suk; Chae, Jei Keon; Lee, Dong Hwan; Kim, Dal Sik; Ko, Jung Ho

doi:10.4070/kcj.2016.46.2.147

Cited by 13 publications

(14 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A hematocrit-induced increase in BV may lead to a decrease in tissue perfusion. BV can be modified using drugs such as vasodilators, statins, or antithrombotics [2,16,17]. A few studies have examined the effect of antithrombotics on BV [17][18][19] and found that warfarin, heparin, and argatroban can decrease BV [17,20].…”

Section: Discussionmentioning

confidence: 99%

Prior antithrombotic use is significantly associated with decreased blood viscosity within 24 hours of symptom onset in patients with acute ischemic stroke

et al. 2019

View full text Add to dashboard Cite

Background: Blood viscosity (BV) is the intrinsic resistance of blood to flow and is a measure of blood stickiness. Several clinical and epidemiologic studies have demonstrated an association between BV and the occurrence of major thromboembolic events. Although BV is significantly higher in cases of lacunar or cardioembolic strokes, its relationship with demographic and laboratory parameters during the acute stage of ischemic stroke is unknown. We investigated the relationship between baseline characteristics of acute ischemic stroke and BV within 24 hours of symptom onset in patients with acute ischemic stroke. Methods: We enrolled patients aged 40 years or older with documented histories of ischemic stroke or transient ischemic attack within 24 hours of symptom onset. A scanning capillary-tube viscometer was used to assess whole BV. Results: The mean age was 69.6±12.03 years and 44.4% of the patients were female. Of 189 patients, 68.3% had a history of hypertension; 27%, diabetes; 42.9%, hypercholesterolemia; 3.7%, coronary artery disease; and 18%, stroke. Additionally, 40.7% were current smokers. Sixty-one patients (32.3%) were regularly taking antithrombotics. Multiple linear regression analysis revealed that hematocrit was positively corelated with increased BV and prior antithrombotic use was corelated with decreased BV. Hematocrit-adjusted partial correlation demonstrated that prior antithrombotic use was significantly associated with decreased BV. Conclusion: Prior antithrombotic use is significantly associated with decreased BV within 24 hours of symptom onset in patients with acute ischemic stroke. Our findings indicate that antithrombotic medications may change the hemorheological profile in these patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Prior antithrombotic use is significantly associated with decreased blood viscosity within 24 hours of symptom onset in patients with acute ischemic stroke

et al. 2019

View full text Add to dashboard Cite

show abstract

“…BV can rise with high levels of aggregating proteins and can be also modified by drug therapy such as anti-hypertensive drugs or statin. 20 In this study, we did not assess the relationship between BV and medication. This trial enrolled only Korean patients, limiting the generalization of data to other geographic regions.…”

Section: Resultsmentioning

confidence: 97%

Middle Cerebral Artery Pulsatility Is Highly Associated with Systemic Blood Viscosity in Acute Ischemic Stroke within 24 Hours of Symptom Onset

Han

Park

Baik

et al. 2019

J Neurosonol Neuroimag

View full text Add to dashboard Cite

Background: Though blood viscosity (BV) is the major factor influencing pulsatility index (PI), it is unknown whether PI is related with BV in acute ischemic stroke. We explored the association between transcranial Doppler (TCD) PI and BV in acute ischemic stroke patient. Methods: Between January 2018 and December 2018, patients aged 40 years or older with an ischemic stroke or transient ischemic attack within 24 hours of symptom onset were recruited for the study. The scanning capillary-tube viscometer was used to assess whole blood viscosity. Doppler signals showing the highest mean flow velocity were used for PI calculation. Results: A total of 125 patients were enrolled for the study. The most frequent stroke subtype was lacunar stroke (42%), followed by stroke of undetermined etiology negative work-up (29%), and large artery atherosclerosis (19%). The mean middle cerebral artery (mMCA) PI was significantly associated with BV. Age, diabetes and BV were associated with mMCA PI, suggesting that increased mMCA PI is associated with old age, presence of diabetes, and increased BV. Conclusion: Pulsatility of MCA is highly associated with BV in acute ischemic stroke patient within 24 hours of symptom onset. Our findings indicate that TCD PI may be a useful non-invasive imaging modality for exploring the viscosity of cerebral vessels, which in turn is related to systemic BV.

show abstract

“…The hypothesis that a lipid-lowering reagent, statin, contributes to blood viscosity decrease is very attractive and gave rise to immediate therapeutic possibilities. Jung et al 1) claimed that this was the first report on the potential effect of statin on blood viscosity reduction. Using a capillary scanning method, 2) they compared diastolic blood viscosity (at a shear rate of 1 s -1 ) and systolic blood viscosity (at a shear rate of 300 s -1 ).…”

mentioning

confidence: 94%

“…In an interesting study, Jung et al 1) found an effective reduction of whole blood viscosity in statin naïve acute coronary syndrome (ACS) patients with early statin administration. In statin naïve ACS patients they found an apparent decrease in whole blood viscosities at both of the two shear rates.…”

mentioning

confidence: 99%