Abstract:Bu çalışmada rosuvastatinin, kardiyopulmoner baypas (KPB) eşliğinde yapılan koroner arter baypas greftleme (KABG) sonrasında mikroalbuminüriyi azaltıp azaltmadığı araştırıldı. Ça lış ma pla nı: Bu prospektif çalışmaya izole KABG yapılan toplam 40 hasta (37 erkek, 3 kadın; ort. yaş 59.0±10.1 yıl; dağılım 48-78 yıl) alındı. Hastalar kontrol grubu (n=20) ve elektif KABG'den yedi gün önce 20 mg/gün rosuvastatin kullanmış hastalardan oluşan rosuvastatin grubu (n=20) olarak ikiye ayrıldı. Tüm hastalardan mikroalbumi… Show more
“…The predictive value of microalbuminuria for the expression of cardiovascular diseases has also been investigated and, in fact, is as powerful for predicting hyperlipidaemia or hypertension. 17 Microalbuminuria also occurs in acute conditions where capillary permeability increases.…”
SummaryObjective:This prospective study aimed to investigate the effects of the selective angiotensin receptor antagonist, telmisartan, on microalbuminuria after coronary artery bypass surgery in patients with diabetes mellitus.Methods:Patients were divided into two groups with block randomisation, using the sealed envelope technique: group T (telmisartan group) consisted of patients who received the angiotensin receptor blocking agent telmisartan 80 mg daily for at least six months in the pre-operative period; group N-T (non-telmisartan group) consisted of patients who received no telmisartan treatment. Clinical and demographic characteristics, operative and postoperative features, microalbuminuria and high-sensitivity C-reactive protein levels were compared.Results:Forty patients met the eligibility criteria for the study. The groups did not differ with regard to clinical and demographic characteristics, and operative and postoperative features. Microalbuminuria levels between the groups differed significantly in the pre-operative period, first hour postoperatively and fifth day postoperatively. C-reactive protein levels between the groups differed significantly on the fifth day postoperatively.Conclusion:Telmisartan was useful for decreasing systemic inflammation and levels of urinary albumin excretion in patients who had type 2 diabetes mellitus and had undergone coronary artery bypass surgery.
“…The predictive value of microalbuminuria for the expression of cardiovascular diseases has also been investigated and, in fact, is as powerful for predicting hyperlipidaemia or hypertension. 17 Microalbuminuria also occurs in acute conditions where capillary permeability increases.…”
SummaryObjective:This prospective study aimed to investigate the effects of the selective angiotensin receptor antagonist, telmisartan, on microalbuminuria after coronary artery bypass surgery in patients with diabetes mellitus.Methods:Patients were divided into two groups with block randomisation, using the sealed envelope technique: group T (telmisartan group) consisted of patients who received the angiotensin receptor blocking agent telmisartan 80 mg daily for at least six months in the pre-operative period; group N-T (non-telmisartan group) consisted of patients who received no telmisartan treatment. Clinical and demographic characteristics, operative and postoperative features, microalbuminuria and high-sensitivity C-reactive protein levels were compared.Results:Forty patients met the eligibility criteria for the study. The groups did not differ with regard to clinical and demographic characteristics, and operative and postoperative features. Microalbuminuria levels between the groups differed significantly in the pre-operative period, first hour postoperatively and fifth day postoperatively. C-reactive protein levels between the groups differed significantly on the fifth day postoperatively.Conclusion:Telmisartan was useful for decreasing systemic inflammation and levels of urinary albumin excretion in patients who had type 2 diabetes mellitus and had undergone coronary artery bypass surgery.
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