Rosuvastatin ameliorates diabetes-induced reproductive damage via suppression of oxidative stress, inflammatory and apoptotic pathways in male rats

Heeba, Gehan H.; Hamza, Alaaeldin Ahmed

doi:10.1016/j.lfs.2015.09.015

Cited by 60 publications

(47 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the current experiment, increased levels of both IL-6 and IL-10 following lead exposure were in the same line with other previous studies (Valentino et al 2007;Li et al 2015). Their increased levels indicated the ability of lead to trigger inflammation which might occur in response to increased oxidative stress through activation of NF-κB (Heeba and Hamza 2015). Interestingly, increased IL-6 could inhibit testosterone production by Leydig cells (Bini et al 2015).…”

Section: Discussionsupporting

confidence: 92%

The protective role of folic acid against testicular dysfunction in lead-intoxicated rat model

Gomaa¹,

Khalil²,

Abdel-Ghani³

2017

gpb

View full text Add to dashboard Cite

There is an increasing concern over male reproductive toxicity caused by lead exposure. Folic acid (FA) is supposed to be a promising therapeutic strategy against lead toxicity. Therefore, the aim of this experimental study was to shed light on the potential protective role of FA on lead-induced testicular dysfunction in rats and its possible underlying mechanistic pathways. Rats (n = 24) were divided into four groups: Control, FA, Lead, and FA+Lead group. After 4 weeks, lead intoxication resulted in a marked reduction in the relative testicular weight and the serum level of testosterone, an impairment in the characters of semen analysis, and an increased content of lead, malondialdehyde and both interleukin-6 and -10 and a decreased antioxidant enzyme levels in the testicular tissue homogenate. Furthermore, marked degenerative histological changes and an increased expression of NF-κB were also noticed in the testicular tissue of Lead group. Supplementation of FA in association with lead considerably alleviated these adverse outcome responses most probably owing to its cytoprotective ability as emerged from combating the oxidative stress and inflammatory reactions. We concluded that FA could act as a highly effective fighting approach against lead-associated testicular toxicity.

show abstract

Section: Discussionsupporting

confidence: 92%

The protective role of folic acid against testicular dysfunction in lead-intoxicated rat model

Gomaa¹,

Khalil²,

Abdel-Ghani³

2017

gpb

View full text Add to dashboard Cite

show abstract

“…Recently, statins have been found to exert biological effects on osteoporosis, inflammation and other diseases in addition to their hypocholesterolemic activities [29][30][31]. Furthermore, several studies have shown that treatment with statins can reduce reproductive damage induced by hypercholesterolemia, however, the mechanisms by which obesity impairs spermatogenic function and how statins help recover from obesity-induced damage in the testes, sperm parameters, sex hormones, and metabolism is still unclear [32]. Here we provide data supporting a protective role for fluvastatin in reproductive damage in HFD-induced obese male rat model and the possible role of mTOR signaling in these effects.…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Fluvastatin on Reproductive Function in Obese Male Rats Induced by High-Fat Diet through Enhanced Signaling of mTOR

Cui

Chen

Zhu

et al. 2017

Cell Physiol Biochem

View full text Add to dashboard Cite

Background: Statins can reduce reproductive damage induced by obesity or high-fat diet (HFD), but the specific regulatory mechanisms are largely unknown. Since mTOR/p70s6k sinaling promotes spermatogonia proliferation and spermatogenesis, we hypothesized that this pathway will be involved in the protective effects of statin in HFD-induced reproductive dysfunction. Methods: Male Sprague Dawley rats (3 weeks old) were randomly divided into a control group (standard diet), HFD group, and a fluvastatin group (HFD + fluvastatin at 6mg/kg, once daily by oral gavage). After 8 weeks, body weight was obtain and rats were sacrificed. Weights of the testes, gross morphology, sperm parameters, circulating levels of sex hormones, lipid levels, and tissue mTOR, p-P70s6k were measured. Another set of male rats were treated with rapamycin or vehicle. Flow cytometry was used to detect the spermatogonia marker c-kit and cell cycle. p-P70s6k expression was analyzed by Western blot. Results: HFD not only results in rat obesity but also leads to spermatogenetic damage and fluvastatin was able to partially block the effects of HFD. Fluvastatin also partially reversed the suppression of mTOR and p-p70s6k expresson. Conclusion: Our data suggest that fluvastatin has protective effects on reproductive function in obese male rats most probably through enhanced signaling of mTOR.

show abstract

“…DM has been associated with negative effects on the male sexual function in humans and animal models including reduced spermatogenesis, erectile dysfunction, ejaculation disorder, sexual behavior and endocrine system abnormalities [1, 6, 8, 13]. It is also associated with the overproduction of reactive oxygen species (ROS) and decreased efficiency of antioxidant defenses [12]. A recent study has suggested that oxidative stress is an important pathophysiological mechanism underlying male reproductive dysfunction [9, 13].…”

mentioning

confidence: 99%

Effects of <i>Vernonia cinerea</i> on reproductive performance in streptozotocin-induced diabetic rats

Pomjunya

Ratthanophart²,

Fungfuang

2017

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

The present study investigated the effects of Vernonia cinerea (VC) on the reproductive function in streptozotocin (STZ)-induced diabetic male rats. Six-week-old male Sprague-Dawley rats were randomly divided into four groups: group 1, normal control rats; group 2, diabetic untreated rats; group 3, diabetic rats treated with VC (10 mg/kg); and group 4, diabetic rats treated with VC (40 mg/kg). Diabetes mellitus (DM) was induced by intraperitoneal injection of STZ (60 mg/kg). All animals were treated for 30 consecutive days. Body weight, blood glucose, food intake, epididymal sperm parameters, testicular microstructure and serum testosterone levels were evaluated. VC treatment significantly restored the sperm motility and testosterone concentration, and decreased the testicular histopathological changes in DM rats. Moreover, high-dose VC exhibited an antidibetic activity and significantly improved the sperm count. In conclusion, we found, for the first time, that administration of VC significantly restored the testicular function and testosterone concentration in diabetic male rats.

show abstract

Rosuvastatin ameliorates diabetes-induced reproductive damage via suppression of oxidative stress, inflammatory and apoptotic pathways in male rats

Cited by 60 publications

References 31 publications

The protective role of folic acid against testicular dysfunction in lead-intoxicated rat model

The protective role of folic acid against testicular dysfunction in lead-intoxicated rat model

Protective Effects of Fluvastatin on Reproductive Function in Obese Male Rats Induced by High-Fat Diet through Enhanced Signaling of mTOR

Effects of <i>Vernonia cinerea</i> on reproductive performance in streptozotocin-induced diabetic rats

Contact Info

Product

Resources

About