Ross syndrome associated with cytomegalovirus infection

Abstract

We report a 40-year-old woman who developed Ross syndrome (impairment of sweating and thermoregulation, tonic pupils, and hyporeflexia) associated with cytomegalovirus (CMV) infection. Her serum CMV IgM and IgG antibody titer levels were elevated. Along with clinical improvement, a gradual decrease of her elevated CMV IgM antibody titer level was seen with a continued increase in her CMV IgG antibody titer level. The CMV IgM antibody titer was also positive in the cerebrospinal fluid.

Ross Syndrome with Sweating Anomaly Associated with Sjögren Syndrome: An Infrared Thermo­graphic Case Study

“…Since it was first described in 1958 (2), approximately 50 cases have been described in the literature (3). Dermatologists may be confronted with this disorder of thermorégulation, which is often revealed by a segmental "compensatory" hyperhidrosis.…”

Ross syndrome: a case report

“…1 More recently, a direct infectious damage to autonomic nerves by an acute cytomegalo virus (CMV) infection has been hypothesized in an isolated case report. 5…”

“…1 Ross syndrome may have an unpredictable course and its causation may be due to various factors like autoimmunity, developmental origin, viral infections etc. [2][3][4][5][6] Since its first description in 1958, approximately 50 cases have been described in literature and only 3 have been reported from India so far.…”

Anhidrosis as the first sign of Ross Syndrome

“…Natural history is frequently slowly progressive, sometimes as long as 50 years 7 . However, Nagane et al 8 have recently described a transitory form of Ross syndrome associated with cytomegalovirus infection, in which the symptoms improved partially with the infection resolution.…”