Rosmarinus officinalis polyphenols activate cholinergic activities in PC12 cells through phosphorylation of ERK1/2

Omri, Abdelfatteh El; Han, Jianzhong; Yamada, Parida; Kawada, Kunio; Abdrabbah, Manef Ben; Isoda, Hiroko

doi:10.1016/j.jep.2010.07.006

Cited by 72 publications

(60 citation statements)

References 40 publications

(36 reference statements)

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“…These anti-AChE and anti-BChE activities are likely caused by rosemarinic acid and terpene compounds in the plant's essential oil [4,36]. By increasing total choline levels in the brain, rosemary could attenuate not just Alzheimer's disease, but also memory loss, anxiety, and depression [37,38]. Two more studies highlight the neuroprotective ability of R. officinalis.…”

Section: Neuroprotective Activitymentioning

confidence: 99%

Rosmarinus Officinalis (Rosemary): A Novel Therapeutic Agent for Antioxidant, Antimicrobial, Anticancer,Antidiabetic, Antidepressant, Neuroprotective, Anti-Inflammatory, and Anti-Obesity Treatment

Hamidpour¹,

Hamidpour²,

Elias³

2017

BJSTR

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Section: Neuroprotective Activitymentioning

confidence: 99%

Rosmarinus Officinalis (Rosemary): A Novel Therapeutic Agent for Antioxidant, Antimicrobial, Anticancer,Antidiabetic, Antidepressant, Neuroprotective, Anti-Inflammatory, and Anti-Obesity Treatment

Hamidpour¹,

Hamidpour²,

Elias³

2017

BJSTR

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“…A recent study on neuro-beneficial effects of phyto-chemicals also suggested that the MAP kinase pathway could mediate xenobioticinduced alterations of AChE in PC-12 cells [15,16]. Interestingly, the MAP kinase pathway also participated in the toxicological effects of dioxin.…”

Section: Potential Signaling Cascades Beyond Ahr-dependent Pathwaysmentioning

confidence: 99%

New perspectives for multi-level regulations of neuronal acetylcholinesterase by dioxins

Xie

Chen

et al. 2016

Chemico-Biological Interactions

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a b s t r a c tAcetylcholinesterase (AChE; EC 3.1.1.7) is a vital functional enzyme in cholinergic neurotransmission which can rapidly hydrolyze neurotransmitter, acetylcholine, in the central and peripheral nervous systems. Emerging evidence showed that in addition to classical environmental AChE inhibitors, e.g. organophosphate and carbamate pesticides, dioxins are a new type of xenobiotic causing impairment of AChE. Dioxin can transcriptionally or post-transcriptionally suppress AChE expression in human neuroblastoma cells or mouse immune cells via the aryl hydrocarbon receptor (AhR) pathway, respectively. Dioxins can affect gene expression through other mechanisms, such as cross-talk with other signaling cascades and epigenetic modulations. Therefore, in this review, by summarizing the known mechanisms of AChE regulation and dioxin-induced gene alteration, potential signaling cascades and epigenetic mechanisms are proposed for dioxin-mediated AChE regulation. Mitogen activated protein (MAP) kinase, 3 0 , 5 0 -cyclic adenosine monophosphate (cAMP) and calcium-related singaling pathways, as well as potential epigenetic mechanisms, such as DNA methylation, and post-transcriptional regulation via microRNAs, including hsa-miR-132, hsa-miR-212 and hsa-miR-25-3p are discussed here. These proposed mechanisms may be invaluable not only to promote comprehensive understanding of the action mechanisms for dioxin, but to illustrate the molecular basis of dioxin-induced health impacts.

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“…In the scientific community, it has demonstrated pharmacological action as a digestive, antispasmodic (Porte, Godoy, 2001), anti-inflammatory, anti-nociceptive (Takaki et al, 2008), anti-ulcer (Dias et al, 2000),hepatoprotective (Amim, Hamza, 2005), diuretic (Haloui et al, 2000) and antimicrobial (Newall, Anderson, Philipson, 2002;Silva et al, 2008), activities attributed to its various constituent phytochemicals (Sasaki et al, 2013).There are reports of the presence of neuroprotective activity for Alzheimer´s (Liu et al, 2009;Lin et al, 2010;El Omri et al, 2010) and Parkinson´s (Park et al, 2010) diseases, related to its major compounds including luteolin, carnosic acid and rosmarinic acid (Adams, Gmunder, Hamburguer, 2007).…”

Section: Introductionmentioning

confidence: 99%

Development of mouthwash with Rosmarinus officinalis extract

Paula

Moraes

Souza

et al. 2014

Braz. J. Pharm. Sci.

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Rosmarinus officinalis, which belongs to the Lamiaceae family, is a species of medicinal flora with therapeutic properties. In order to exploit the benefits of these properties, a mouthwash formulation was developed, with careful selection of raw materials to meet pharmacotechnical requirements. Extracts of the plant were incorporated into a mouthwash, which was shown to have inhibitory action in vitro against the micro-organisms commonly found in periodontics. Controls for assessing the quality of the drugs were carried out, quantifying phenols and flavonoids as chemical markers. Mouthwash solutions were formulated containing 0.1, 5 and 10% ethanol extract of R. officinalis; and 0.05, 5 and 10% of the hexane fraction of R. officinalis. In order to evaluate synergism, ethanol extract and hexane fraction were also added to formulations containing 0.05% sodium fluoride and 0.12% chlorhexidine digluconate. These formulations were assessed for inhibitory effect against the specific microorganisms involved in the process of bacterial plaque formation, S. mutans (ATCC25175) and C. albicans(ATCC 10231), frequently found in cases of oral infections. The agar diffusion method was used to evaluate the inhibitory activity of extracts and formulations. All mouthwash solutions displayed inhibitory activity having higher sensitivity to S. mutans for the 5% ethanol extract+0.05% sodium fluoride, and greater sensitivity to C. albicans for the 10% hexane fraction. Results were characterized by the appearance of a growth inhibition halo, justifying the utilization and association of extracts of R. officinalis. Uniterms:Rosmarinus officinalis/pharmacognosy. Rosmarinus officinalis/Anti-microbial activity. Mouthwash. Periodontics/use of mouthwash. Medicinal plants.Rosmarinus officinalis, pertencente à família Lamiaceae, é um exemplar da flora medicinal que possui propriedades terapêuticas. No intuito de usufruir destes benefícios, desenvolveu-se uma formulação de enxaguatório bucal com seleção criteriosa de matérias-primas que atendessem os requisitos farmacotécnicos. Incorporaram-se extratos dessa planta e verificou-se a capacidade inibitória in vitro frente a micro-organismos frequentemente encontrados em periodontias. Controles foram efetuados para a avaliação da qualidade dos fármacos, quantificando-se como marcadores químicos, os fenóis e os flavonóides. Formulações de enxaguatórios contendo 0,1, 5 e 10% de extrato etanólico de R. officinalis; e 0,05, 5 e 10% da fração hexânica de R. officinalis foram preparadas. Para avaliar o sinergismo, o extrato e a fração hexânica também foram adicionados às formulações que continham fluoreto de sódio 0,05% e diguclonato de clorexidina 0,12%. Nessas formulações avaliou-se a capacidade inibitória frente a micro-organismos específicos do processo de formação de placa bacteriana, S. mutans (ATCC 25175) e C. albicans (ATCC 10231), frequentemente encontrada em quadros de infecções orais. Foi empregado o método de difusão em ágar para a avaliação da atividade inibitória dos extratos e das formul...

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Rosmarinus officinalis polyphenols activate cholinergic activities in PC12 cells through phosphorylation of ERK1/2

Abstract: R. officinalis' CA and RA exhibited neurotrophic effects in PC12 cells through cell differentiation induction and cholinergic activities enhancement. These effects could be regulated by mitogen-activated protein kinase (MAPK), ERK1/2 signaling pathway.

Cited by 72 publications

References 40 publications

Rosmarinus Officinalis (Rosemary): A Novel Therapeutic Agent for Antioxidant, Antimicrobial, Anticancer,Antidiabetic, Antidepressant, Neuroprotective, Anti-Inflammatory, and Anti-Obesity Treatment

Rosmarinus Officinalis (Rosemary): A Novel Therapeutic Agent for Antioxidant, Antimicrobial, Anticancer,Antidiabetic, Antidepressant, Neuroprotective, Anti-Inflammatory, and Anti-Obesity Treatment

New perspectives for multi-level regulations of neuronal acetylcholinesterase by dioxins

Development of mouthwash with Rosmarinus officinalis extract

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