Rosmarinus officinalis L. leaf extract improves memory impairment and affects acetylcholinesterase and butyrylcholinesterase activities in rat brain

Ożarowski, Marcin; Mikołajczak, Przemysław Ł.; Bogacz, Anna; Gryszczyńska, Agnieszka; Kujawska, Małgorzata; Jodynis‐Liebert, Jadwiga; Piasecka, Anna; Napieczyńska, Hanna; Szulc, Michał; Kujawski, Radosław; Bartkowiak‐Wieczorek, Joanna; Cichocka, Joanna; Bobkiewicz-Kozlowska, T.; Czerny, Bogusław; Mrozikiewicz, P.M.

doi:10.1016/j.fitote.2013.09.012

Cited by 141 publications

(102 citation statements)

References 39 publications

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“…These anti-AChE and anti-BChE activities are likely caused by rosemarinic acid and terpene compounds in the plant's essential oil [4,36]. By increasing total choline levels in the brain, rosemary could attenuate not just Alzheimer's disease, but also memory loss, anxiety, and depression [37,38]. Two more studies highlight the neuroprotective ability of R. officinalis.…”

Section: Neuroprotective Activitymentioning

confidence: 99%

Rosmarinus Officinalis (Rosemary): A Novel Therapeutic Agent for Antioxidant, Antimicrobial, Anticancer,Antidiabetic, Antidepressant, Neuroprotective, Anti-Inflammatory, and Anti-Obesity Treatment

Hamidpour¹,

Hamidpour²,

Elias³

2017

BJSTR

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Section: Neuroprotective Activitymentioning

confidence: 99%

Rosmarinus Officinalis (Rosemary): A Novel Therapeutic Agent for Antioxidant, Antimicrobial, Anticancer,Antidiabetic, Antidepressant, Neuroprotective, Anti-Inflammatory, and Anti-Obesity Treatment

Hamidpour¹,

Hamidpour²,

Elias³

2017

BJSTR

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“…It had inhibition of formalin-induced pain and inflammation in mice (Emami et al 2013) and H 2 O 2 induced oxidative DNA damage in human lymphocytes (Razavi-Azarkhiavi et al 2014). It improved memory impairment via modulation acetylcholinesterase and butyrylcholinesterase activities in rat brain (Ozarowski et al 2013). …”

Section: Herbal Remedies With Female Antifertility and Abortificiant mentioning

confidence: 99%

The use of medicinal herbs in gynecological and pregnancy-related disorders by Jordanian women: a review of folkloric practice vs. evidence-based pharmacology

Akour

Kasabri

Afifi

et al. 2016

Pharmaceutical Biology

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Context National statistical reports in Jordan indicate a decrease in the total fertility rate along with a parallel increase in contraceptive use. The folkloric use of medicinal herbs in gynecological disorders has been growing in Jordan, despite of deficient reports on the evidence-based safety and efficacy of these practices. Objective The aim of this comprehensive article is to review medicinal plants with claimed ethnonpharmacological usage in various gynecological and pregnancy-related issues in Jordan, and to assess their evidence-based pharmacological studies as well as their phytochemistry. Methods The published literature was surveyed using Google Scholar entering the terms ''ethnopharmacology AND Jordan AND infertility AND gynecology OR gestation''. We included ethnopharmacological surveys in Jordan with available full-text. Results Twelve articles were reviewed. Plant species which are commonly used for female gynecological issues such as Artemisia monosperma Del. and A. herba-alba Asso. (Asteraceae) have been found to exert an antifertility effect. Ricinus communis L. (Euphorbiaceae) and Citrullus colocynthis (L.) Schrad. (Cucurbitaceae) had antifertility effects in male rats, but Nigella sativa oil L. (Ranunculaceae) and Cinnamon zeylanicum J. Presl (Lauraceae) were found to enhance it. Conclusion Using plants for gynecological disorders is a common practice in Jordan. Many of them, whether utilised for gynecological or non-gynecological conditions equally, were found to have detrimental effects on female or male fertility. Thus, couples planning pregnancy should be discouraged from the consumption of these herbs. Further local studies are warranted to confirm the appreciable beneficial pharmacological effects and safety of these plants. ARTICLE HISTORY

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“…A recent review of Rosemary explains the therapeutic role it may play to aid those with Alzheimer's disease [4]. Various studies have demonstrated that Rosemary's bioactives support brain health and may have a role in enhancing cognitive function [37]. As mentioned, Hemerocallis has anti-depressant effects, as well as being neuroprotective.…”

Section: Discussionmentioning

confidence: 99%

Impact of the Dietary Supplement CLOCK® on BDNF and Other Biochemical Measures Related to Cognitive Function and Health in Men and Women

Bloomer

2017

ACIM

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Background: We have previously reported improvements in selected biochemical measures of health, as well as self reported well-being in men and women using the dietary supplement known as CLOCK ® . In this follow up investigation, we evaluated CLOCK ® at two different dosages using a randomized, placebo controlled, cross-over design in men and women with self reported low energy, impaired sleep quality and impaired well-being.Methods: 30 subjects (14 men and 16 women) were randomly assigned in double blind manner to ingest a botanical agent (CLOCK ® , containing Rosmarinus officinalis and Hemerocallis fulva at either 1gram or 1.5grams daily) or a placebo for two week periods with a two week wash out period after each condition assignment. Blood samples were collected pre and post each two week period in an overnight fasted state and analyzed for acetylcholine (ACh), choline, Brain Derived Neurotrophic Factor (BDNF), IGF-1, irisin, melatonin and serotonin. Heart rate and blood pressure were measured, as were subjective measures of well-being. The Leeds Sleep Evaluation Questionnaire was used as a measure of sleep quality and related variables.Results: ACh (22%), choline (19%), BDNF (44%), irisin (23%) and melatonin (8%) all increased significantly from pre to post intervention following intake of CLOCK ® (with a greater increase noted with 1gram vs. 1.5grams) but not placebo. Heart rate and blood pressure were unaffected by treatment (p>0.05). Time effects were noted for all well-being measures (p<0.05), except for anxious, depressed and tense, with improvements noted in all variables from pre to post intervention. When considering both supplement dosages together, improvements of 25% (attentiveness), 21% (alertness), 37% (focus) and 34% (energetic) were observed, with slightly less improvement noted for placebo. Although, not significant, CLOCK ® reduced the feeling of grogginess (25%), lethargy (14%) and sluggishness (18%); whereas there were minimal changes with the placebo. No differences were noted between conditions or across time in measures of sleep or related variables (p>0.05).

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Rosmarinus officinalis L. leaf extract improves memory impairment and affects acetylcholinesterase and butyrylcholinesterase activities in rat brain

Cited by 141 publications

References 39 publications

Rosmarinus Officinalis (Rosemary): A Novel Therapeutic Agent for Antioxidant, Antimicrobial, Anticancer,Antidiabetic, Antidepressant, Neuroprotective, Anti-Inflammatory, and Anti-Obesity Treatment

Rosmarinus Officinalis (Rosemary): A Novel Therapeutic Agent for Antioxidant, Antimicrobial, Anticancer,Antidiabetic, Antidepressant, Neuroprotective, Anti-Inflammatory, and Anti-Obesity Treatment

The use of medicinal herbs in gynecological and pregnancy-related disorders by Jordanian women: a review of folkloric practice vs. evidence-based pharmacology

Impact of the Dietary Supplement CLOCK® on BDNF and Other Biochemical Measures Related to Cognitive Function and Health in Men and Women

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