Rosmarinic Acid Induces Apoptosis of Activated T Cells from Rheumatoid Arthritis Patients via Mitochondrial Pathway

Hur, Yun-Gyoung; Suh, Chang‐Hee; Kim, Sungjoo; Won, Jonghwa

doi:10.1007/s10875-006-9057-8

Cited by 49 publications

(41 citation statements)

References 57 publications

(54 reference statements)

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“…RosA promotes apoptosis in human Jurkat T lymphoma cells via a mitochondrial pathway and suppressed by Bcl-2 in which caspases act as apoptosis executioners rather than as mitochondrial dysfunction inducers (Hur et al, 2004;Kolettas et al, 2006). The apoptosis of activated T cells from rheumatoid arthritis patients also can be induced by RosA treatment (Hur et al, 2007). Our result was confirmed by these reports that one of roles of RosA in apoptosis induction in HepG2 cells is via mitochondrial pathway.…”

Section: Discussionsupporting

confidence: 87%

Growth inhibitory and apoptosis inducing effect of Perilla frutescens extract on human hepatoma HepG2 cells

Lin

Kuo

Wang

et al. 2007

Journal of Ethnopharmacology

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Section: Discussionsupporting

confidence: 87%

Growth inhibitory and apoptosis inducing effect of Perilla frutescens extract on human hepatoma HepG2 cells

Lin

Kuo

Wang

et al. 2007

Journal of Ethnopharmacology

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“…Another known effect of Ros A is that it participates in the promotion of T cell apoptosis. A recent study with rheumatoid arthritis (RA) patients indicated that Ros A induces apoptosis of activated T cell subsets-including CD3 + /CD25 + , CD4 + /CD25 + , and CD4 + /CD45RO + T cells-via a mitochondrial pathway (Hur et al, 2007). To evaluate the synergistic effect of Ros A plus MR1 (the double therapy) in a murin allogeneic skin graft model, skin grafts from BALB/c mice were transplanted into C57BL/6 mice that had been treated with the double therapy.…”

Section: Discussionmentioning

confidence: 99%

Prolonged survival of islet allografts in mice treated with rosmarinic acid and anti-CD154 antibody

et al. 2008

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Pancreatic islet transplantation can correct the abnormal glucose metabolism of Type 1 diabetes. Although immunosuppressants greatly reduce the acute rejection rate in transplant patients, the long-term side effects can be debilitating. Therefore, researchers are seeking to develop new immunosuppressive regimens that induce maximal levels of immunosuppression with minor side effects. Rosmarinic acid (Ros A) is a secondary metabolite of certain herbs and has multiple biological activities, including anti-inflammatory effects. Here, we have investigated whether treatment of mice with a combination of Ros A and anti-CD154 monoclonal antibody (MR1) improves islet allograft survival in a murine model. After transplantation, the mice were treated with either Ros A, MR1, or both (the "double" treatment). Allograft survival was prolonged in the double-treated animals compared to animals that received only Ros A or MR1. As is the case with the single-treated animals at 15 days after transplantation, the double-treated recipients did not display a significant decrease in the expression of cytokines or the population of activated T cells. Infiltrating CD3 + T cells were reduced in the MR1-or double therapy relative to control or RosA group. However, at the same time point, double-treated graft showed fewer apoptotic cells and increased expression of insulin and glucagons, compared to the single-treatment groups. Furthermore, long-term (＞ 150 days) allografts that were received with double therapy exhibited larger islet clusters and contained more insulin-and glucagon-positive cells, relative to the MR1-treated grafts. In conclusion, treatment with both Ros A and MR1 has a synergistic effect in murine islet allotransplantation.

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“…Rosmarinic acid also induces apoptosis of activated T-cells, which play an important role in RA (Hur et al, 2007).…”

Section: Lamiaceaementioning

confidence: 99%

Medicinal herbs for the treatment of rheumatic disorders—A survey of European herbals from the 16th and 17th century

Adams

Berset

Kessler

et al. 2009

Journal of Ethnopharmacology

172

105

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Rosmarinic Acid Induces Apoptosis of Activated T Cells from Rheumatoid Arthritis Patients via Mitochondrial Pathway

Cited by 49 publications

References 57 publications

Growth inhibitory and apoptosis inducing effect of Perilla frutescens extract on human hepatoma HepG2 cells

Growth inhibitory and apoptosis inducing effect of Perilla frutescens extract on human hepatoma HepG2 cells

Prolonged survival of islet allografts in mice treated with rosmarinic acid and anti-CD154 antibody

Medicinal herbs for the treatment of rheumatic disorders—A survey of European herbals from the 16th and 17th century

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