Rosmarinic acid in perilla extract inhibits allergic inflammation induced by mite allergen, in a mouse model

Abstract

These results suggest that oral administration of perilla-derived rosmarinic acid is an effective intervention for allergic asthma, possibly through the amelioration of increases in cytokines, chemokines, and allergen-specific antibody.

Extraction of Luteolin and Apigenin from Leaves of <i>Perilla frutescens</i> (L.) Britt. with Liquid Carbon Dioxide

“…Previous investigations have discovered that some polyphenols extracted from P. frutescens exhibit pharmacological activities such as anti-allergy, anti-inflammatory [1] and anti-oxidant [2]. Among these components, luteolin and apigenin, the common flavones which are contained in a wide range of beneficial or dietary plants including weld (Reseda luteola L.), carrot (Daucus carota subsp.…”

“…Generally substances were prepared with organic solvents such as ethanol, methanol, acetone and toluene. Whereas some researchers developed and applied sophisticated methods [2], simple maceration at a range of temperatures is broadly accepted and common practice [1,3]. Recently, supercritical carbon dioxide (SC-CO 2 ) extraction has provoked considerable interest as a separation technique in many fields [5][6][7][8][9][10][11][12][13].…”

Two cases of anaphylaxis caused by perilla seed

“…Several in vivo and in vitro studies have demonstrated that perilla can suppress IgE-mediated responses, [1][2][3] and no previous cases of allergic reactions or anaphylaxis induced by the perilla seed have been reported.…”

“…However, allergists in Australia, 2 Britain, 3 and France, 4 among others, often rely on skin prick testing (SPT) in the diagnosis of food allergy. We would therefore like to share our experience in defining cutoff values for SPT wheal diameters that predict positive challenge outcomes to tree nuts and sesame.…”

“…The challenge procedure for tree nuts and sesame was adapted from our previously described method for peanut. 2 In brief, 1 / 8 to 1 / 4 teaspoon increments of finely ground unsalted nuts were administered at intervals of 20 to 30 minutes, as tolerated, until a total dose of 20 g was reached. Double-blind, placebo-controlled challenges were performed only if the open challenge was inconclusive.…”