Rosiglitazone stimulates peroxisome proliferator-activated receptor gamma expression and directly affects in vitro steroidogenesis in porcine ovarian follicles

Rak, Agnieszka; Karpeta, Anna

doi:10.1016/j.theriogenology.2014.02.016

Cited by 23 publications

(15 citation statements)

References 29 publications

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“…It has been frequently reported that activators of PPARg regulate steroidogenesis in follicular cells of different species but the available results are contradictory. Stimulatory effect of synthetic or natural activators of PPARg on P 4 secretion was noted in mixed culture of human stromal, theca and granulosa cells [34], rat granulosa cells [35], ovine granulosa cells [14], porcine theca cells [20] and porcine follicles [36]. In turn, a lack of changes in P 4 or E 2 production was observed in human granulosa-lutein cells [29].…”

Section: Ppars and Steroidogenesismentioning

confidence: 98%

“…However, inconsistency in their expression and activity has been often demonstrated by researchers. For instance, a stimulatory effect of PPARg activation on steroidogenesis can be mediated by up-regulation of steroidogenic acute regulatory (StAR) protein in human and macaque granulosa cells [44,45] or by 3b-HSD in porcine ovarian follicles [36]. An opposite effect of PPARg ligands on 3b-HSD expression and P 4 release was observed in porcine granulosa cells [37].…”

Section: Ppars and Steroidogenesismentioning

confidence: 99%

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Peroxisome proliferator-activated receptors in the regulation of female reproductive functions

Bogacka

Kurzyńska

Bogacki

et al. 2015

Folia Histochem Cytobiol.

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Peroxisome proliferator-activated receptors (PPARs) belong to a ligand-dependent nuclear receptor family. In the past decade, numerous studies have revealed the presence and significance of PPARs in the reproductive system. PPARs are expressed at different levels of hypothalamic-pituitary-gonadal (HPG) axis. They are also present in the uterus as well as in the placenta and embryonic tissues of different species. PPARs significance has been reported during the estrous/menstrual cycle and pregnancy with the gamma isoform studied most frequently. Several studies indicate that PPARs regulate proliferation of ovarian cells, tissue remodeling and steroidogenesis. In the endometrium, PPARs are engaged in the regulation of prostaglandins, steroids and cytokines synthesis. The role of PPARs in the trophoblast differentiation, maturation and invasion as well as in the embryo development has also been demonstrated. In this review, we summarize current findings concerning the role of PPARs in the regulation of reproductive functions at different levels of the HPG axis during various physiological statuses of females. In addition, the role of PPARs in the modulation of uterine functions as well as the placenta and embryo development has also been discussed.

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Section: Ppars and Steroidogenesismentioning

confidence: 98%

Section: Ppars and Steroidogenesismentioning

confidence: 99%

Peroxisome proliferator-activated receptors in the regulation of female reproductive functions

Bogacka

Kurzyńska

Bogacki

et al. 2015

Folia Histochem Cytobiol.

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“…In bottlenose dolphins, relaxin has only recently has been detected and evaluated for basic and applied purposes (review Bergfelt et al, 2014). A heterologous relaxin radioimmunoassay (RIA) was developed and validated using human relaxin, rabbit anti-porcine relaxin, and synthetic canine relaxin to initially characterize immunoreactivity in samples collected periodically during an approximate 12-month gestation period in aquarium-based dolphins (Bergfelt et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…In bottlenose dolphins, the increase in relaxin concentrations that occurs during late pregnancy (Bergfelt et al, 2011) has provided preliminary evidence suggesting that relatively high concentrations prior to parturition may play a role during the birthing process comparable to that in other mammalian species (Porter, 1993; Sherwood, 1994). In addition, elevated concentrations of relaxin may also serve as a diagnostic aid to hormonally detect pregnancy status as proposed in other wildlife species (Bergfelt et al, 2014; Steinetz, 2005 and 2009). …”

Section: Introductionmentioning

confidence: 99%

“…The implication that relaxin may serve as a hormonal indicator of pregnancy in bottlenose dolphins as proposed in other wildlife species (Bergfelt et al, 2014; Steinetz, 2005 & 2009) is based, in part, on the pregnancy-specific nature of relaxin in dolphins. Relatively high concentrations of relaxin pre-partum subsequently decreased during the early post-partum period (Bergfelt et al, 2011), concentrations above baseline indicative of pregnancy were detected in pregnant but not in non-pregnant dolphins (Bergfelt et al, 2013), and high concentrations of relaxin (1 to 3 mg/kg) were detected in tissue extracts from multiple full-term placentas of dolphins (Bergfelt et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Relaxin as a hormonal aid to evaluate pregnancy and pregnancy loss in bottlenose dolphins (Tursiops truncatus)

Bergfelt

Blum

Steinetz

et al. 2017

General and Comparative Endocrinology

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This study was conducted to critically evaluate weekly and monthly circulating concentrations of immunoreactive relaxin throughout pregnancies that resulted in live births, stillbirths, and abortions in aquarium-based bottlenose dolphins. A relaxin RIA was used to analyze serum collected during 74 pregnancies involving 41 dolphins and 8 estrous cycles as well as 8 non-pregnant dolphins. Pregnancies resulted in live births (n=60), stillbirths (n=7), or abortions (n=7). Relative to parturition (Month 0), monthly changes (P<0.0001) in relaxin was indicated by relatively low concentrations during early pregnancy (Month −12 to −9) which subsequently increased (P<0.05) during mid- (Months −8 to −5) to late (Months −4 to −1) pregnancy; relaxin was highest (P<0.05) at the time of parturition. Post-parturition (Month 1), concentrations decreased (P<0.05). During the first 4 wk post-ovulation, relaxin concentrations were not different between pregnant and non-pregnant dolphins (status-by-week interaction, P=0.59). Status-by-month interaction (P<0.0002) involving different pregnancy outcomes was due, impart, to an increase in relaxin during early pregnancy (P<0.05) that was comparable among dolphins with live births, stillbirths, and abortions except concentrations were lower (P<0.05; 52%) at mid-pregnancy in association with pregnancy loss. Thereafter, concentrations increased (P<0.05) during late pregnancy in dolphins with stillbirths but not in dolphins with abortions. In conclusion, this study provided new information on the pregnancy-specific nature of relaxin, critical evaluation of the fundamental characteristics of relaxin during pregnancy and pregnancy loss, and clarification on the strengths and limitations of relaxin as a diagnostic aid to determine pregnancy status and assess maternal-fetal health in bottlenose dolphins.

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Adipose tissue and ovarian aging: Potential mechanism and protective strategies

Huang²,

Zhu³

et al. 2022

Ageing Research Reviews

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Rosiglitazone stimulates peroxisome proliferator-activated receptor gamma expression and directly affects in vitro steroidogenesis in porcine ovarian follicles

Cited by 23 publications

References 29 publications

Peroxisome proliferator-activated receptors in the regulation of female reproductive functions

Peroxisome proliferator-activated receptors in the regulation of female reproductive functions

Relaxin as a hormonal aid to evaluate pregnancy and pregnancy loss in bottlenose dolphins (Tursiops truncatus)

Adipose tissue and ovarian aging: Potential mechanism and protective strategies

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