Rosette-forming T cells in human peripheral blood at different ages

Carosella, Edgardo D.; Mochanko, K; Braun, Marta

doi:10.1016/0008-8749(74)90085-9

Cited by 72 publications

(22 citation statements)

References 7 publications

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“…After overnight incubation, the levels of E rosettes in old people increased and the differences between the two groups decreased to values similar to those reported by Augener et al (1974). Other investigators have reported smaller (Smith et al, 1974) and larger differences (Carosella et al, 1974) between these 2 groups, but the rosetting methods used have been different from those used in this study.…”

Section: Discussionsupporting

confidence: 75%

“…Some authors (Stjernsward et al, 1972;Nemoto et at., 1974) have reported that the proportion of T lymphocytes is normal in patients with breast cancer who have not received radiotherapy, whereas others Keller et at., 1976) have reported decreased levels of T lymphocytes in these patients. There is a similar disparity in results in studies of the effect of age on T-lymphocyte levels (Augener, Cohnen and Reuter, 1974;Carosella, Mochanko and Braum, 1974;Smith, Evans and Steel, 1974;Alexopoulos and Babitis, 1976;Teasdale et al, 1976).…”

mentioning

confidence: 94%

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Importance of methodology in demonstrating depression of T-lymphocyte levels

Whitehead¹,

Roberts²,

Hughes³

et al. 1978

Br J Cancer

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A comparison has been made of 3 methods of determining E rosettes in young, healthy people, women with breast cancer and an age-matched group of healthy women, in an attempt to explain the wide variations in T-cell levels in different disease states reported by different workers. The greatest difference in levels of E-rosetting cells between the different groups was seen in incubation of 1 1/2 h at 4 degrees C. Much of the difference seen in these comparisons disappeared after overnight incubation at 4 degrees C, which was associated with an increased T-cell level in all groups. Consequently, although maximal levels of T lymphocytes as determined by E rosetting are found using overnight incubation, a short incubation period may be superior for demonstrating subtle depressions in levels of T lymphocytes as seen in elderly people and cancer patients. This depression is not considered to be cancer specific, because of the findings in the age-matched control group and similar findings in benign disease states.

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Section: Discussionsupporting

confidence: 75%

mentioning

confidence: 94%

Importance of methodology in demonstrating depression of T-lymphocyte levels

Whitehead¹,

Roberts²,

Hughes³

et al. 1978

Br J Cancer

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“…These results agree with some studies (4,32) but stand in contrast with other reports (10,28) which demonstrate a significant reduction in the absolute number of lymphocytes and T cells. The exact explanation for the difference in the findings between these two studies is not available.…”

Section: Discussioncontrasting

confidence: 56%

Age-Related Variation in Lymphocyte Subpopulations

Davey¹,

Huntington²

1977

Gerontology

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Peripheral blood lymphocytes are heterogeneous and can be divided into subpopulations based on cell surface markers. Lymphocytes from 101 normal individuals of all ages were tested for their ability to form spontaneous rosettes with sheep erythrocytes (T cells) and for surface immunoglobulins (B cells). Cord bloods of newborn infants and bloods from children (age 1–10 years) showed greater numbers of total lymphocytes, total T cells and unmarked cells than a control group of 50 individuals from age 11–60 years. In 22 normal elderly individuals (age 61–98 years), total lymphocytes and total T and B cells were not decreased. These data suggest that the depression of cellular immune response described in elderly populations may be related to a dysfunction in a segment of T cells or an aberration in the complex interaction among T cells, B cells and macrophages.

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“…When rosettes were estimated in differ ent age groups, we could not find a percen tage or absolute decrease with age, as was demonstrated by Carosella et al [1974] and Augener et al [1974] measuring E RFC.…”

Section: Discussionmentioning

confidence: 66%

E and EAC Rosette-Forming Cells in Healthy Donors and Cancer Patients

Middelkoop

Veldhuizen

Scheper

1976

Int Arch Allergy Immunol

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The influence of age and sex on the lymphocyte count and numbers of E and EAC rosette-forming cells (RFC) was investigated using peripheral blood of healthy donors. In the female donors we found a lower total lymphocyte count and percentage of EAC RFC than in male donors. The percentage and total number of E RFC appeared to be low in younger donors. Total lymphocyte count and numbers of E and EAC RFC were investigated in untreated and treated patients with advanced solid tumors and in patients with untreated malignant lymphomas. The lymphocyte count in all these groups was decreased, but the E/EAC RFC ratio was normal, except in the group with untreated solid tumors, where we found an increased percentage of E RFC. It is suggested that in these patients a nonspecific impairment of bone marrow function might be expressed in numbers of peripheral T and B cells.

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Rosette-forming T cells in human peripheral blood at different ages

Cited by 72 publications

References 7 publications

Importance of methodology in demonstrating depression of T-lymphocyte levels

Importance of methodology in demonstrating depression of T-lymphocyte levels

Age-Related Variation in Lymphocyte Subpopulations

E and EAC Rosette-Forming Cells in Healthy Donors and Cancer Patients

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