Rosemary oil low energy nanoemulsion: optimization, µrheology, <i>in silico, in vitro, and ex vivo</i> characterization

Vasdev, Nupur; Handa, Mayank; Kesharwani, Prashant; Shukla, Rahul

doi:10.1080/09205063.2022.2088527

Cited by 10 publications

(8 citation statements)

References 38 publications

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“…Similarly, Tween 80, ethanol, and DGME had characteristic peaks, as previously reported by authors in Vasdev et al research manuscript …”

Section: Resultssupporting

confidence: 82%

“…Characteristics peaks of DPZ with the aromatic phenone group showed a peak at around 1684.91 cm −1 , C�C stretching comes at around 1596 cm Similarly, Tween 80, ethanol, and DGME had characteristic peaks, as previously reported by authors in Vasdev et al research manuscript. 37 LC−MS was the analytical method employed for the simultaneous estimation of DPZ and MEM. As MEM has no active chromophore regions, it is impossible to quantify the MEM in formulation or in vitro release studies.…”

Section: Resultsmentioning

confidence: 99%

“…Thus, nasal ciliotoxicity studies confirm that NE1 nanoemulsion is safe for further in vivo studies. 37 The above nasal ciliotoxicity studies demarcate using NE1 nanoemulsion for further in vivo studies. In the current research, we have performed pharmacodynamic and pharmacokinetic studies to establish the safety and efficacy of nanoemulsions delivered via the intranasal route and comparison with the peroral route.…”

Section: Discussionmentioning

confidence: 98%

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Simultaneous Intranasal Codelivery of Donepezil and Memantine in a Nanocolloidal Carrier: Optimization, Pharmacokinetics, and Pharmacodynamics Studies

Handa,

Sanap,

Bhatta

et al. 2023

Mol. Pharmaceutics

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This work focuses on developing nanoemulsions using a low-energy emulsification method for the codelivery of donepezil and memantine in one dosage form intended to be administered via the intranasal route for enhanced brain delivery. The nanoemulsion formulation was prepared using a low emulsification technique and characterized using various microscopy and nasal ciliotoxicity studies. The safe nanoemulsion was intended for preclinical pharmacokinetics with brain distribution and pharmacodynamics in a scopolamine-induced murine model. The formulated nanoemulsion was 16 nm in size, with a zeta potential of −7.22 mV, and exhibited a spherical shape. The brain concentration of IN-administered NE for DPZ and MEM was ∼678 and 249 ng/mL after 15 min. This concentration is more than 2 times higher in amount when compared with NE administered via PO, free drug solution administered via IN and PO route both. However, the plasma concentration of IN-administered NE for DPZ and MEM was ∼3 and 28 ng/mL after 15 min. In pharmacodynamic studies, the efficacy of NE administered via the IN route was higher when compared with other groups in neurobehavioral, biochemical estimation, and gene expression studies. The results suggest that the IN route can be explored in the future for the delivery of actives via nanocolloidal carriers in the brain for neurological disorders and can serve as promising alternatives for conventional dosage forms and routes.

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“…Similarly, Tween 80, ethanol, and DGME had characteristic peaks, as previously reported by authors in Vasdev et al research manuscript …”

Section: Resultssupporting

confidence: 82%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 98%

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Simultaneous Intranasal Codelivery of Donepezil and Memantine in a Nanocolloidal Carrier: Optimization, Pharmacokinetics, and Pharmacodynamics Studies

Handa,

Sanap,

Bhatta

et al. 2023

Mol. Pharmaceutics

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“…Molecular docking was used for the preliminary study of the different activities of the multifunctional neuroprotective peptides screened using the MiCNN–LSTM model and non-neuroprotective peptides. It has been reported that the antioxidant, anti-inflammatory, anti-cholinergic deficiency and anti-Aβ accumulation activities of compounds can be investigated by docking with Keap1 (PDB ID: ), 36 p38α (PDB ID: ), 37 AChE (PDB ID: ) 38 and BACE1 (PDB ID: ), 39 respectively. Therefore, the docking of peptides with these proteins was carried out.…”

Section: Methodsmentioning

confidence: 99%

Multi-dimensional deep learning drives efficient discovery of novel neuroprotective peptides from walnut protein isolates

Zhang

et al. 2023

Food Funct.

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“…Rosemary oil is among the well-known essential oils that carry tremendous functional properties which are useful in lowering oxidative stress and inflammations and are used for commercial purposes in the cosmetic industry and skin care products (Vasdev et al, 2022). Rosemary oil has also shown exceptional properties in the food industry as a natural preservative and in the nutraceutical industry as an oral supplement.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2023

Pak. J. Pharm. Sci.,

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Carnosic acids and other bioactive substances in rosemary essential oil help regulate weight by decreasing dietary fat absorption. This study examined how 380mg of encapsulated rosemary oil affected body mass index and waist-to-hip ratio. 40 obese women were studied. The eight-week study. Before and after the study, BMI and WHR were measured. This study used two-sample t-tests. This study found that rosemary oil was a light-yellow liquid with a distinct smell and soluble in polar solvents like alcohol. Its relative density was 0.91±0.18, the refractive index was 1.39±0.06, pH was 6.01±0.31, and optical rotation was -4.87 o . It contained moisture content (9.27±1.38)%, total ash (6.98±0.18)%, water soluble ash (4.01±0.06)%, and acid soluble ash (1.89±0.31)%. Total phenolic content (TPC) was 123.74±0.02mg GAE/g and total flavonoid content (TFC) was 57.21±0.11mg QE/g. Results showed a significant reduction in body mass index in treatment groups. The treatment group showed a reduction in body mass index from 37.29±9.86 to 35.21±18.74. However, the control group showed no change. Results showed a significant reduction in the waist-to-hip ratio from 0.97±0.03 to 0.91±0.04. However, the control group showed a slight increase in the waist-to-hip ratio over the period. Thus, rosemary oil can be useful in the management of obesity.

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Rosemary oil low energy nanoemulsion: optimization, µrheology, in silico, in vitro, and ex vivo characterization

Cited by 10 publications

References 38 publications

Simultaneous Intranasal Codelivery of Donepezil and Memantine in a Nanocolloidal Carrier: Optimization, Pharmacokinetics, and Pharmacodynamics Studies

Simultaneous Intranasal Codelivery of Donepezil and Memantine in a Nanocolloidal Carrier: Optimization, Pharmacokinetics, and Pharmacodynamics Studies

Multi-dimensional deep learning drives efficient discovery of novel neuroprotective peptides from walnut protein isolates

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